Bone and fat cross-talk in antiretroviral therapy (ART) treated HIV patients

抗逆转录病毒疗法 (ART) 治疗的 HIV 患者的骨和脂肪交叉对话

• 批准号: 10856307
• 负责人: Ryan Dee Ross
• 金额: $ 17.56万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10856307
• 关键词: Administrative Supplement; Affect; Age; Aging; Animals; Anti-Retroviral Agents; Area; Award; Back; Biological; Chicago; Chronic Disease; Clinical; Cohort Studies; Collaborations; Country; Data; Data Set; Demographic Factors; Development; Enrollment; Face; Fatty acid glycerol esters; Flow Cytometry; Foundations; Funding; Future; Goals; HIV; HIV Infections; High Prevalence; Hip region structure; Immune; Joints; Knee; Linear Regressions; Longevity; Meleagris gallopavo; Metabolic; Modeling; Mus; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal Pain; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Nigeria; Outcome Study; Pain; Pain Research; Parents; Participant; Patient Outcomes Assessments; Patients; Pattern; Persons; Physical assessment; Pilot Projects; Population; Positioning Attribute; Prevalence; Publishing; Quality of life; Questionnaires; Reporting; Research; Rheumatism; Risk; Risk Factors; Sampling; Severities; Sex Differences; Specificity; Spinal Ganglia; Surveys; Symptoms; Testing; United States National Institutes of Health; Vulnerable Populations; Woman; Work; Zambia; antiretroviral therapy; biological sex; bone; bone loss; clinical research site; cohort; comorbidity; cooking; design; experience; experimental study; frailty; human subject; immune cell infiltrate; improved; innovation; insight; interest; large datasets; lifestyle factors; men; mouse model; novel; pain reduction; parent grant; pre-clinical; secondary analysis; skin disorder

Project Summary / Abstract The widespread use of combination antiretroviral therapy (cART) has significantly increased the lifespan of people living with HIV (PLWH). As HIV has become a chronic disease, there is a growing concern of the disproportionate risk of a variety of comorbidities. In our parent award, we are focused on two comorbidities that occur at a higher prevalence in cART treated PLWH - bone loss and fat gain. Our proposal focuses on the contribution of antiretrovirals to the development of these two conditions and utilizes a novel preclinical mouse model of HIV infection and cART treatment and human subjects data from a large-scale NIH-funded cohort study of PLWH. The current administrative supplement seeks to leverage these ongoing studies to extend our efforts into pain research and to generate supporting evidence towards a future scientific direction in pain research. Specifically, we seek to investigate musculoskeletal pain, which is a common concern of PLWH in patient reported outcome studies. We will leverage our ongoing animal work to investigate the biological mechanisms (Aim 1) and our ongoing collaboration with the MWCCS to obtain define the joint- specific patterns of musculoskeletal pain in women living with HIV (Aim 2). If successful, the supplemental aims will generate exciting new data on the prevalence and potential risk factors for musculoskeletal pain development in PLWH and provide the PI with experience and preliminary data to further research pain mechanisms in this vulnerable population. Importantly, the supplemental aims align with several areas of scientific interest within NIAMS, including focusing on immune mechanisms of pain, making large data sets relevant to pain research, and leveraging existing datasets for secondary analysis for pain research.

项目摘要 /摘要 联合抗逆转录病毒疗法（CART）的广泛使用已显着提高了 患有艾滋病毒（PLWH）的人。随着艾滋病毒已成为一种慢性疾病，人们对 多种合并症的风险不成比例。在我们的父母奖中，我们专注于两种合并症 这在卡车处理过的PLWH-骨质流失和脂肪增加的情况下发生。我们的建议重点是 抗逆转录病毒对这两种情况的发展的贡献，并利用了一种新型的临床前小鼠 来自大规模NIH资助的队列的HIV感染和购物治疗模型以及人类受试者数据 PLWH的研究。当前的行政补充旨在利用这些正在进行的研究来扩展我们的 在疼痛研究中的努力，并为未来的科学方向提供支持证据 疼痛研究。具体而言，我们试图调查肌肉骨骼疼痛，这是 患者的PLWH报告了结果研究。我们将利用我们正在进行的动物工作来调查 生物学机制（AIM 1）和我们与MWCC的持续合作来定义联合 患有艾滋病毒的女性肌肉骨骼疼痛的特定模式（AIM 2）。如果成功，补充 目标将产生有关肌肉骨骼疼痛的患病率和潜在危险因素的激动人心的新数据 在PLWH中开发并为PI提供经验和初步数据，以进一步研究疼痛 这个脆弱人群的机制。重要的是，补充性的目的与 NIAM内的科学兴趣，包括专注于疼痛的免疫机制，制作大量数据 与疼痛研究相关的集合，并利用现有数据集进行次要分析进行疼痛 研究。