Optimizing PrEP implementation and effectiveness among women at high risk for HIV acquisition in South Africa

优化南非艾滋病毒感染高风险女性的 PrEP 实施和有效性

• 批准号: 10600564
• 负责人: Sheree Renae Schwartz
• 金额: $ 4.25万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-14 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600564
• 关键词: AIDS prevention; Award; Caring; Centers for Disease Control and Prevention (U.S.); Clinical Research; Cluster randomized trial; Effectiveness; Female Adolescents; Funding; Goals; Grant; HIV; HIV/TB; High Risk Woman; Infectious Disease Epidemiology; Mentors; Mentorship; Modification; Outcome; Parents; Performance; Qualitative Research; Research Methodology; Research Personnel; South Africa; Testing; Time; Training Activity; Underrepresented Minority; Woman; Work; career; career development; clinical practice; disadvantaged background; experience; female sex worker; implementation fidelity; implementation science; implementation strategy; insight; parent grant; pre-exposure prophylaxis; programs; service delivery; uptake; young woman

Project Summary/Abstract This application is to provide mentorship and career development to a promising URM as part of a diversity supplement to grant R01MH121161. The parent award seeks to understand ongoing implementation of PrEP service delivery across two large CDC/PEPFAR funded awards to TB HIV Care in South Africa, which serve the HIV prevention female sex workers and adolescent girls and young women nationally. The parent award further aims to optimize PrEP implementation strategies to enhance PrEP uptake and persistence among women, through short duration cluster randomized trials which test modifications and additions to ongoing program implementation. The proposed application, will build upon the existing study objectives and expand the scope by studying the adaptation of strategies over time, as well as the impact of these adaptations on the fidelity of implementation. These adjustments are beyond the scope of the currently funded study which assessed the impact of the introduction of implementation strategies on PrEP uptake and persistence, and is studying the relationship between new/tweaked strategies on PrEP performance outcomes. Assessing adaptation of strategies over time is new, and will help to elicit new insights into fidelity of implementation, including fidelity consistent and fidelity inconsistent adaptations, which will provide further insights into program performance over time, as well as durability of implementation and impact of implementation strategies. Training activities will focus on expanding skillsets of the candidate, an underrepresented minority from a disadvantaged background, in implementation science, qualitative research methods and causal inference, preparing the candidate for a future research career. The mentoring team has several collective years of mentorship experience, including in implementation science, quantitative and qualitative research methods, PrEP programming, clinical research and practice and infectious disease epidemiology.

项目概要/摘要 该应用程序旨在为有前途的 URM 提供指导和职业发展，作为多元化的一部分 补充授予R01MH121161。家长奖旨在了解 PrEP 的持续实施 CDC/PEPFAR 资助的两项大型奖项为南非的结核病艾滋病护理提供服务，这些奖项服务于 全国女性性工作者、少女和年轻妇女的艾滋病毒预防。家长奖 进一步的目标是优化 PrEP 实施策略，以提高 PrEP 的采用率和持久性 女性，通过短期整群随机试验测试正在进行的修改和补充 方案实施。拟议的应用程序将建立在现有研究目标的基础上并扩展 通过研究策略随时间的变化以及这些变化对 执行的保真度。这些调整超出了目前资助的研究的范围 评估了实施策略的引入对 PrEP 的采用和持久性的影响，并且 研究新的/调整的策略与 PrEP 绩效结果之间的关系。评估 随着时间的推移调整策略是新的，并将有助于对实施的忠诚度产生新的见解， 包括保真度一致和保真度不一致的改编，这将为项目提供进一步的见解 随着时间的推移，绩效以及实施的持久性和实施战略的影响。 培训活动将侧重于扩大候选人的技能组合，候选人是来自少数群体的代表性不足的少数群体。 弱势背景，在实施科学、定性研究方法和因果推理方面， 为候选人未来的研究生涯做好准备。导师团队拥有多年集体经验 指导经验，包括实施科学、定量和定性研究方法， PrEP 规划、临床研究和实践以及传染病流行病学。