Administrative Core

行政核心

• 批准号: 10596708
• 负责人: PEI ZHONG
• 金额: $ 4.03万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10596708
• 关键词: Ablation; Address; Benign; Clinical; Clinical Research; Clinical Treatment; Collaborations; Communities; Consultations; Data Scientist; Development; Development Plans; Disease; Dust; Educational workshop; Ensure; Fiber; Frequencies; Future; Goals; Health Expenditures; Holmium; In Situ; Injury to Kidney; Knowledge; Laser Lithotripsy; Lasers; Lead; Liquid substance; Mentored Clinical Scientist Development Program; Mentors; Mentorship; Methods; Nanotechnology; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrology; Outcome; Patients; Play; Positioning Attribute; Prevalence; Procedures; Program Development; Public Health; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Role; SECTM1 gene; Sampling; Science; Structure; Talents; Technology; Thulium; Time; Tissues; Toxic effect; Training; Treatment outcome; Universities; Ureteroscopy; Urinary Calculi; Urology; Work; absorption; career; career development; cost; data sharing; experience; improved; innovation; member; multidisciplinary; nanomaterials; nanoparticle; novel strategies; operation; programs; theories; tissue injury; tool; treatment choice; urologic

ADMINISTRATIVE CORE (AC) PROJECT SUMMARY/ABSTRACT Urinary stone disease (USD) is the second most costly urologic condition in the US, with an annual healthcare expenditure of more than $2 billion. Ureteroscopy (URS) via laser lithotripsy (LL) is the treatment of choice for USD. Recently, the introduction of high power/high frequency Holmium (Ho): YAG lasers and Thulium Fiber Laser (TFL) has fundamentally altered the clinical mode of operation in LL. Contemporary LL is often performed using dusting and pop-dusting modes that pulverize stone to dust in situ without the need for fragment extraction. However, there is an unmet need to develop approaches that can address some of the challenges of dusting and pop-dusting in order to significantly improve the clinical treatment outcome regardless of stone composition, shorten the procedure time, and lessen the risk of tissue injury. The proposed Duke FORWARD P20 Urology Center (Duke FORWARD Center) will tackle some of the most pressing problems in treating USD with LL. The Center's Research Project (RP) will focus on modifying the fluid medium to enhance the inherent cavitation or photothermal ablation mechanism for stone ablation during another critical clinical procedure, called pop-dusting, so that the treatment efficiency can be improved, while the procedure time and potentially collateral tissue damage will be reduced. The RP will be led by Po-Chun Hsu, a promising junior investigator new to USD research with expertise in nanotechnology for heat and thermal management that will be central to the RP's strategy. The primary goal of Duke FORWARD's Administrative Core (AC) is to guide and support the efforts of the Center's RP Team to successfully conduct their project and help prepare them to apply for future R01s. The Specific Aims of the AC are to: (1) Facilitate productive collaborations among the RP Team and with the broader CAIRIBU research community; and (2) implement a career development plan for RP PI Po-Chun Hsu for him to gain experience and mastery in USD research knowledge and technical capabilities. If the aims of the AC are achieved, the RP Team will have successfully accomplished the aims of their RP and will be in a position to submit one or more follow-on R01s by Year 3 of the proposed Center. In supporting the Center, the AC will facilitate innovative research with the potential to benefit millions of USD patients worldwide and will have introduced this talented new USD research team to the NIDDK-sponsored CAIRIBU benign urology research community.

行政核心（AC）项目摘要/摘要 尿石病（USD）是美国第二昂贵的泌尿科状况，并拥有年度医疗保健 超过20亿美元的支出。通过激光碎石（LL）的输尿管镜检查（URS）是选择的治疗 美元。最近，引入了高功率/高频率霍尔姆（HO）：YAG激光器和Thulium纤维 激光（TFL）从根本上改变了LL的临床操作模式。当代LL经常进行 使用粉尘和弹出的模式，将石头粉碎到原位粉尘，而无需碎片提取。 但是，有未满足的需要开发可以解决灰尘挑战的方法 和弹出式戒烟，以显着改善临床治疗结果，无论石材成分如何 缩短了程序时间，并减少了组织损伤的风险。拟议的杜克大学泌尿外科 中心（杜克向前中心）将解决用LL治疗美元的一些最紧迫的问题。这 中心研究项目（RP）将着重于修改流体介质以增强固有的空化或 在另一种关键的临床程序中，石材消融的光热消融机制，称为弹出式缠绕 从而可以提高治疗效率，而过程时间和潜在的附带组织 损害将减少。 RP将由Po-Chun Hsu领导，Po-Chun Hsu是新的新少年调查员 具有纳米技术专业知识的热量和热管理的研究，这将是RP的核心 战略。杜克（Duke）前锋行政核心（AC）的主要目标是指导和支持努力 该中心的RP团队成功执行了他们的项目，并帮助他们为将来的R01申请。 AC的具体目的是：（1）促进RP团队之间的富有成效合作 更广泛的Cairibu研究社区； （2）为RP PI PO-CHUN HSU实施职业发展计划 让他获得美元研究知识和技术能力的经验和精通。如果目的 实现了AC，RP团队将成功实现其RP的目标，并将处于位置 在拟议中心的第三年之前，提交一个或多个后续R01。在支持中心时，AC将 促进创新研究，有可能使全球数百万美元的患者受益 向NIDDK赞助的Cairibu良性泌尿外科研究介绍了这个才华横溢的新USD研究团队 社区。