Improving Mechanistic Understanding and Treatment Efficiency of Laser Lithotripsy

提高激光碎石机制的理解和治疗效率

• 批准号: 10019531
• 负责人: PEI ZHONG
• 金额: $ 30.95万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-18 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10019531
• 关键词: Acoustics; Address; Benign; Biomedical Engineering; Biophotonics; Budgets; Clinic; Clinical; Clinical Management; Clinical Treatment; Collaborations; Communication; Development; Devices; Disease; Education; Educational Technology; Emergency department visit; Engineering; Entrepreneurship; Event; Foundations; Frequencies; Future; Genitourinary system; Goals; Growth; Infrastructure; Interdisciplinary Study; Investigation; Kidney; Knowledge; Laser Lithotripsy; Lasers; Lithotripsy; Manufacturer Name; Mechanics; Medical Device; Modality; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrolithiasis; Operative Surgical Procedures; Optics; Outcome; Pain; Patient-Focused Outcomes; Patients; Performance; Physiologic pulse; Recurrence; Repeat Surgery; Reporting; Research; Research Personnel; Research Project Grants; Residual state; Safety; Shock; Surgical Management; System; Talents; Technology; Time; Tissues; Training; Training Programs; Universities; Ureteroscopy; Urinary Calculi; Urogenital Diseases; Urologist; Urology; Work; biomedical scientist; clinical care; cost; engineering design; experience; follow-up; improved; innovation; interest; materials science; mechanical properties; medical specialties; meetings; multidisciplinary; next generation; novel; organizational structure; outreach; patient oriented; photonics; programs; recruit; success; synergism; technological innovation; technology development; technology/technique; urologic; web site

OVERALL: SUMMARY ABSTRACT Nephrolithiasis (or commonly known as urinary stone disease) is a benign but severely painful genitourinary disease that is on the rise and is the second most costly urologic condition in the US at over $2 billion per year. The treatment of nephrolithiasis is shifting away from shock wave lithotripsy (SWL) to intracorporeal laser lithotripsy (LL) via ureteroscopy, but the foundational knowledge of laser-stone-tissue interaction and LL technology has not advanced commensurably with its growing use in clinical care. At present, there is a pressing need for a fundamental and comprehensive investigation of the existing LL technologies and the dissimilar mechanisms of action associated with various modes of LL. Such an effort will be timely and crucial to optimize LL for improved patient-oriented outcomes and long-term surgical management of stone disease. Therefore, the overarching goal of this P20 application is to develop a Center for Urological Laser Technologies (CULT) at Duke University that will synergistically combine the expertise in engineering and urology to better understand the dissimilar laser technologies and techniques used clinically for stone management. This center will focus on a Research Project. The center's team will consist of investigators with expertise in urology, biophotonics, heat transfer, computational mechanics, and materials science to address the challenges faced in advancing laser technologies to treat stone disease. The center's Research Project has two Specific Aims focusing on (1) Characterizing comprehensively the optical, thermal, acoustic, and mechanical properties of kidney and artificial stones of different compositions and investigate the dissimilar mechanisms of stone damage produced by various modes of LL; and (2) Performing an in-depth analysis of laser-induced cavitation bubble dynamics in correlation with stone retropulsion and treatment efficiency produced by different LL devices. The center's Administrative Core will provide infrastructure required to manage the scientific oversight of CULT's Research Project studies and oversee the organizational, budgeting, reporting, outreach, communications, and educational goals of the CULT. CULT's EEP will provide a novel training experience in engineering design and entrepreneurship to the next generation of bioengineers in close collaboration with clinicians interested in benign genitourinary research. Synergies and knowledge created by CULT are expected to propel technological innovation and development in LL systems forward, in collaboration with a leading LL manufacturer Dornier MedTech and other medical device companies, benefitting millions of stone patients worldwide.

总体：摘要摘要 肾结石病（或通常称为尿石病）是一种良性但严重疼痛的泌尿生殖器 疾病正在上升，是美国第二昂贵的泌尿科状况，每年超过20亿美元。 肾结石病的治疗正在从冲击波碎石（SWL）转移到体内激光器 通过输尿管镜检查岩性疗法（LL），但激光 - 岩石组织相互作用和LL的基础知识 技术尚未与临床护理中日益增长的使用相称。目前，有一个紧迫的 需要对现有LL技术和不同的基本调查进行基本和全面的调查 与各种模式相关的作用机理。这样的努力对于优化将是及时和至关重要的 LL可改善以患者为导向的结局和对石材疾病的长期手术管理。因此， 该P20应用的总体目标是在杜克 大学将协同结合工程和泌尿科专业知识，以更好地了解 不同的激光技术和技术在临床上用于石材管理。这个中心将重点放在 研究项目。该中心的团队将包括具有泌尿外科专业知识的研究人员 转移，计算技巧和材料科学，以应对推进激光面临的挑战 治疗石材疾病的技术。该中心的研究项目有两个具体目标，重点是（1） 全面表征肾脏和人造的光学，热，声学和机械性能 不同组成的石头，并研究了由 各种LL模式； （2）对激光诱导的气泡气泡动力学进行深入分析 与不同LL设备产生的石材缩回和处理效率的相关性。中心的 行政核心将提供管理对邪教研究的科学监督所需的基础设施 项目研究并监督组织，预算，报告，外展，沟通和教育 邪教的目标。 Cult的EEP将提供工程设计方面的新培训经验和 与对良性有兴趣的临床医生密切合作，为下一代生物工程师的企业家精神 泌尿生殖研究。邪教创造的协同作用和知识有望推动技术 LL Systems向前的创新和开发与领先的LL制造商Dornier合作 MedTech和其他医疗设备公司，使全球数百万个石头患者受益。