Midcareer Investigator Award in Patient-Oriented Research for Dr. Ryan Branski

Ryan Branski 博士荣获以患者为导向的研究中的职业生涯中期研究员奖

• 批准号: 10593155
• 负责人: Ryan Comfort Branski
• 金额: $ 16.6万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593155
• 关键词: Acoustics; Acute; Address; Aerodigestive Tract; Affect; Aftercare; Age; Anatomy; Auditory; Award; Behavioral; Bolus Infusion; Botulinum Toxins; Classification; Clinical; Clinical Sciences; Clinical assessments; Communication; Communication impairment; Complex; Data; Deglutition; Deglutition Disorders; Dimensions; Discipline; Disease; Dystonia; Essential Tremor; Exclusion; Faculty; Family; Functional disorder; Funding; Goals; Health; Human; Laboratories; Limb Tremors; Limb structure; Location; Measures; Medical; Mentors; Mentorship; Midcareer Investigator Award in Patient-Oriented Research; Mission; Movement Disorders; National Institute on Deafness and Other Communication Disorders; Neurologic; Nomenclature; Operative Surgical Procedures; Oral; Oropharyngeal; Outcome; Parkinsonian Disorders; Patient Care; Patient Self-Report; Patients; Persons; Pharmacological Treatment; Pharyngeal structure; Phenotype; Population; Positioning Attribute; Postdoctoral Fellow; Primidone; Process; Propranolol; Publications; Recording of previous events; Refractory; Research; Research Personnel; Severities; Standardization; Structure; Students; Systemic Therapy; Therapeutic; Training; Translational Research; Tremor; Update; Upper Extremity; Variant; Voice; Work; botulinum neurotoxin injection; career; career development; clinical phenotype; disability; experience; feeding; improved; insight; kinematics; medical schools; multidisciplinary; patient oriented research; patient population; pharmacologic; programs; skills; translational impact; treatment effect

PROJECT SUMMARY/ABSTRACT Tremor affects ~1% of the global population or nearly 80 million people. In spite of this staggering figure, both nomenclature and treatment approaches are inconsistent. Many patients present with tremor affecting the voice, either in isolation or in combination with tremor of the limbs. Isolated vocal tremor was historically considered a clinical variant of essential tremor (ET). Recently updated classification criteria, however, exclude isolated voice tremor from ET classification. This controversy provides an ideal platform for meaningful patient- oriented research with the potential to substantively address issues related to communication-related disability. In addition, this K24 midcareer award will allow me to enhance the quantity and quality of mentoring I provide to students, residents, fellows, and junior faculty. My research focus for this award will be on understanding differences in the clinical phenotypes between these two patient populations and the impact of voice tremor on structures of the upper aerodigestive tract and deglutition. In addition, foundational efficacy data regarding pharmacological therapy for patients with voice tremor will be collected. Both Career Goals and Research Aims, consistent with the mission of the National Institute on Deafness and Other Communication Disorders, are proposed for this K24 midcareer award. With regard to career development and mentorship, the following Career Goals are proposed: Career Goal 1. To evaluate the quality of my mentoring and implement a plan for improvement through a formalized training plan Career Goal 2. To mentor junior students, post-doctoral scholars, residents, fellows, and faculty in translational science to enhance patient care through scientific discovery In addition, a multi-disciplinary team has been assembled to address the following Research Aims: Aim 1. To characterize overlapping and/or distinguishing clinical phenotypes of patients with ETVT and iVT. Aim 2. To correlate VT severity with altered deglutition in ETVT and iVT. Aim 3 (Exploratory). To compare systemic and locally administered pharmacological treatment effects for ETVT and iVT.

项目摘要/摘要 震颤影响了约1％的全球人口或近8000万人。尽管有这个惊人的身影， 命名法和治疗方法不一致。许多患者出现震颤，影响 声音，要么孤立或与四肢震颤结合使用。孤立的声音震颤历史上是 被认为是必需震颤（ET）的临床变体。但是，最近更新的分类标准不包括 与ET分类中隔离的配音震颤。这一争议为有意义的患者提供了理想的平台 - 面向研究的研究有可能解决与沟通相关的残疾有关的问题。 此外，这项K24中级护理奖将使我能够增强我提供的指导数量和质量 给学生，居民，研究员和初级教师。我对该奖项的研究重点是理解 这两个患者人群之间的临床表型和配音震颤的影响 上层气管和脱水的结构。此外，有关的基础功效数据 将收集针对语音震颤患者的药理治疗。 职业目标和研究目标都与美国国家耳聋研究所的使命一致 该K24中级护理奖提出了其他沟通障碍。关于职业 发展和指导，提出了以下职业目标： 职业目标1。评估我的指导质量并通过 正式的培训计划 职业目标2。指导初级学生，博士后学者，居民，研究员和教职员工的翻译 通过科学发现来增强患者护理的科学 此外，已经组装了一个多学科团队来解决以下研究目的： 目标1。表征ETVT和IVT患者的重叠和/或区分临床表型。 目的2。将VT严重程度与ETVT和IVT中的变化变化相关。 目标3（探索性）。比较ETVT的系统性和本地管理的药理治疗效果 和IVT。