The neural mechanisms and mnemonic consequences of sound processing during sleep

睡眠期间声音处理的神经机制和记忆后果

基本信息

批准号：
10734969
负责人：
Ada Eban-Rothschild
金额：
$ 49.2万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-15 至 2028-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10734969
关键词：
Acoustics Acute Address Amendment Arousal Auditory area Auditory system Behavioral Brain Brain region Chronic Communication Dependence Dopamine Electroencephalography Electrophysiology (science)Event Exposure to Familiarity Health Policy Hippocampus Household Impaired cognition Impairment Infant Investigation Joints Knowledge Light Link Memory Memory impairment Mus Names Neighborhoods Neurons Noise Nucleus Accumbens Optics Pattern Persons Process Property Public Health Research Rodent Role Semantics Signal Transduction Sleep Sleep disturbances Stimulus Testing Ventral Tegmental Area Wakefulness behavioral response cognitive process cost dopaminergic neuron epidemiology study experimental study insight long term memory memory consolidation memory process memory retention neural neuromechanism neurophysiology noise exposure noise pollution novel optogenetics semantic processing sound urban setting

Acoustics Acute Address Amendment Arousal Auditory area Auditory system Behavioral Brain Brain region Chronic Communication Dependence Dopamine Electroencephalography Electrophysiology (science)Event Exposure to Familiarity Health Policy Hippocampus Household Impaired cognition Impairment Infant Investigation Joints Knowledge Light Link Memory Memory impairment Mus Names Neighborhoods Neurons Noise Nucleus Accumbens Optics Pattern Persons Process Property Public Health Research Rodent Role Semantics Signal Transduction Sleep Sleep disturbances Stimulus Testing Ventral Tegmental Area Wakefulness behavioral response cognitive process cost dopaminergic neuron epidemiology study experimental study insight long term memory memory consolidation memory process memory retention neural neuromechanism neurophysiology noise exposure noise pollution novel optogenetics semantic processing sound urban setting

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项目摘要

Project Summary Despite the overall reduced responsiveness to external stimuli during sleep, incoming sounds are processed by a highly active and broadly projecting auditory system. Moreover, not only the acoustic aspects of sounds are processed during sleep but also their associated meaning, as evidenced by a higher likelihood of awakening from novel and meaningful sounds as compared to familiar and meaningless sounds. These and other findings suggest that there is ongoing semantic neural processing during sleep, yet the underlying brain circuits and neurophysiological mechanisms remain poorly understood. Sound salience processing during sleep enables rapid arousal when a behavioral response is appropriate, such as in the presence of danger or when an infant is in need. However, as millions of people in the US and worldwide live in noisy urban environments, in which they are exposed to household, traffic and other neighborhood sounds during sleep, ongoing processing of sounds during sleep may come at a cost. During sleep in the absence of incoming sounds, brain circuits engage in internally generated neural activity patterns that underlie memory consolidation–the transformation of temporary and labile memory traces into long-term memories. A potential interaction between sound processing and memory processes during sleep has been proposed by recent epidemiological studies which link exposure to nighttime noise and memory impairments. Moreover, we have recently discovered that acute exposure to non-awakening sounds during sleep impairs subsequent memory retention in rodents. However, the acoustic properties of sounds impairing memory consolidation, the consequences of chronic exposure to sounds during sleep on memory capacities and the neural interactions between online sound processing with offline neurophysiological signatures of memory consolidation are largely unknown. We will fill these knowledge gaps using electrophysiological and optical recordings from multiple brain regions, closed-loop sound manipulations and light-activated modulation of neural activity in freely behaving and naturally sleeping mice. In Aim 1, we will determine the role of key brain regions in sound salience processing during wakefulness–the auditory cortex and ventral tegmental area–in processing of sound salience during sleep. In Aim 2, we will determine the acoustic properties of sounds that impair memory processes and the consequences of chronic sound exposure during sleep on memory capacities. In Aim 3, we will determine the acute and chronic consequences of sound processing during sleep on circuit-level neurophysiological mechanisms of memory consolidation. Together, these experiments will provide a mechanistic understanding of the neuronal substrates underlying sound processing during sleep and their mnemonic consequences.

项目摘要尽管睡眠期间对外部刺激的反应总体降低，但仍在处理传入的声音通过高度活跃且广泛投影的听觉系统。而且，不仅声音的声学方面在睡眠期间处理，但也是它们相关的含义，这证明了更高的可能性与熟悉和毫无意义的声音相比，新颖和有意义的声音唤醒。这些和其他发现表明，睡眠期间存在着持续的语义神经化学来源电路和神经生理机制的理解仍然很少。声音显着处理期间当行为响应适当时，睡眠会引起快速唤醒，例如在存在危险或当婴儿需要时。但是，随着美国和全世界的数百万人生活在嘈杂的城市中在睡眠期间，环境暴露于家庭，交通和其他邻里声音，睡眠期间正在进行的声音处理可能是有代价的。在没有传入的情况下睡觉期间声音，大脑电路从内部产生的神经活动模式进行了记忆的基础合并 - 临时记忆和标签记忆痕迹转变为长期记忆。潜力近期已经提出了声音处理和睡眠过程中的记忆过程之间的相互作用流行病学研究将暴露与夜间噪声和记忆力障碍联系起来。而且，我们有最近发现，睡眠期间的急性暴露于不醒目的声音后续记忆保留啮齿动物。但是，听起来的声学特性会损害记忆巩固，睡眠期间长期暴露于声音对记忆容量和神经相互作用的后果通过在线声音处理与离线神经生理学的记忆合并的签名是在很大程度上未知。我们将使用来自多个大脑区域的电生理和光学记录来填补这些知识差距，自由行为和自然会睡觉的老鼠。在AIM 1中，我们将确定关键大脑区域在声音显着性处理中的作用在清醒期间 - 听觉皮层和腹侧段区域 - 在处理过程中的声音显着性睡觉。在AIM 2中，我们将确定损害记忆过程的声音的声学特性和睡眠期间慢性声音暴露对记忆容量的后果。在AIM 3中，我们将确定在电路级神经生理学上睡眠期间声音处理的急性和慢性后果记忆合并的机理。这些实验将共同提供机械理解在睡眠期间的声音处理及其助攻后果的神经元底物的。