Motor and multisystem symptom clusters in children with Autism Spectrum Disorder (ASD): A SPARK dataset study

自闭症谱系障碍 (ASD) 儿童的运动和多系统症状群：一项 SPARK 数据集研究

基本信息

批准号：
10593950
负责人：
Anjana Narayan Bhat
金额：
$ 23.57万
依托单位：
UNIVERSITY OF DELAWARE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10593950
关键词：
Address Affect Age Ataxia COVID-19 pandemic Child Childhood Clinical Cognition Complex DSM-V Data Data Set Databases Developmental Coordination Disorders Diagnosis Diagnostic Enrollment Equus caballus Evaluation Factor Analysis Future General Population Impairment Intervention Knowledge Language Measures Mental disorders Modeling Motor Motor Skills Movement National Institute of Mental Health Nature Neurodevelopmental Disorder Odds Ratio Outcome Parents Pattern Phenotype Play Population Heterogeneity Prevalence Quality of life Questionnaires Recreation Relative Risks Reporting Reproducibility Research Research Domain Criteria Risk Sample Size Sampling School-Age Population Sensory Services Severities Social Behavior Structure Subgroup Symptoms System Time Vaccines Variant autism spectrum disorder autistic children behavioral impairment cohort communication behavior comorbidity developmental disease diagnostic criteria dual diagnosis motor behavior motor impairment motor symptom repetitive behavior sex skills social social communication social communication impairment symptom cluster trend

项目摘要

PROJECT SUMMARY Motor impairments are pervasive in school-age children with Autism Spectrum Disorder (ASD); however, they are often ignored and remain undiagnosed and untreated. Approximately 87% of the SPARK cohort of children with Autism Spectrum Disorder (ASD), the largest ASD cohort in the US, is at-risk for a motor impairment/DCD based on findings from the Developmental Coordination Disorder (DCD) Questionnaire (Bhat, 2020). Yet, motor impairments are not part of the diagnostic criteria or specifiers for ASD per the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V). Although motor domain was added to the NIMH research domain criteria (RDoC) for mental disorders only last year, motor issues have not been discussed as part of the RDoC for ASD. It is unclear if a unique pattern of motor impairments and multisystem impairments (motor, social communication, and repetitive behavior) are present in children with ASD. Do these patterns of impairment change across the ASD spectrum for certain sub- phenotypes or are they generalized across sex, age, comorbid diagnoses, and levels of impairment? In the proposed project, we will study the associations between motor impairment, autism severity, and comorbidities in children with ASD. Specifically, we will determine the risk for motor impairment in children with ASD and how that changes with increasing social communication impairment, repetitive behavior severity, comorbidities, and levels of impairment using parent report measures: DCD-Q, Social Communication Questionnaire (SCQ), and Repetitive Behavior Scale-Revised (RBS-R). Our analyses will also provide further evidence for generalized but unique patterns of motor impairments in children with ASD and if present, the presence of multisystem symptom clusters and sub-phenotypes of ASD. We will also highlight the issue of differential access to various therapies (OT, PT, recreational) for children with ASD and how those do not relate to a child’s risk for motor impairment, thus revealing under-diagnosis and under-treatment for motor issues in ASD using PT and recreational therapies. As the COVID crisis evolves and we wait for reliable treatments and vaccines, resuming pediatric face to face research will take a long time. Using large databases such as the SPARK study dataset to answer critical research questions is therefore, timely and essential.

项目摘要自闭症谱系障碍的学龄儿童（ASD）的运动障碍无处不在；但是，他们通常被忽略并保持未经诊断和未经治疗。大约87％的火花队列与自闭症谱系障碍（ASD）是美国最大的ASD队列，对于运动障碍/DCD而言，处于危险中根据发展协调障碍（DCD）问卷的发现（Bhat，2020）。但是，电动机根据诊断和统计手册精神障碍，第五版（DSM-V）。尽管将电动机域添加到NIMH研究领域标准（RDOC），仅用于精神障碍一年，作为ASD的RDOC的一部分，尚未讨论运动问题。目前尚不清楚是否是独特的模式运动障碍和多系统障碍（运动，社会交流和重复行为）是出现在ASD的儿童中。是否有这些障碍的模式在ASD频谱之间进行某些子频谱的变化表型还是在性别，年龄，合并症诊断和损害水平上概括？在拟议的项目中，我们将研究运动障碍，自闭症严重程度和 ASD儿童的合并症。具体来说，我们将确定患有儿童的运动障碍的风险 ASD及其如何随着社交沟通障碍的增加，重复行为严重性而变化，合并症和使用父报告措施的损害水平：DCD-Q，社交交流问卷（SCQ）和重复行为量表重新定义（RBS-R）。我们的分析也将进一步提供 ASD儿童且如果存在的通用运动障碍的广义但独特的运动模式的证据 ASD的多系统症状簇和子表型的存在。我们还将重点介绍针对患有各种疗法（OT，PT，娱乐性）儿童的差异问题的问题 ASD以及那些与儿童有运动障碍风险无关的，从而揭示了诊断不足和使用PT和娱乐疗法的ASD中运动问题的治疗不足。随着危机的发展和我们等待可靠的治疗和疫苗，恢复小儿面对面的研究将需要很长时间。使用因此基本的。