ETG-4000 Optical Topography System

ETG-4000光学形貌系统

• 批准号: 9074999
• 负责人: Anjana Narayan Bhat
• 金额: $ 52.83万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9074999
• 关键词: Adult; Affect; Area; Autistic Disorder; Behavior; Behavior Therapy; Behavioral; Biological Models; Brain; Brain Injuries; Cerebral Palsy; Child; Childhood; Chronic low back pain; Clinical Research; Data; Delaware; Development; Down Syndrome; Elderly; Electroencephalography; Electrophysiology (science); Equilibrium; Functional Magnetic Resonance Imaging; Funding; Individual; Infant; Locomotion; Motor; Movement; Neurorehabilitation; Oppositional Defiant Disorder; Optics; Patients; Play; Population; Positioning Attribute; Psychopathology; Request for Proposals; Research Personnel; Short-Term Memory; Stroke; Symptoms; System; Technology; Translational Research; United States National Institutes of Health; Universities; Walking; Work; arm function; base; brain behavior; cognitive neuroscience; high risk infant; infrared spectroscopy; interdisciplinary collaboration; interest; named group; neuroimaging; neuromechanism; programs; psychosocial; relating to nervous system; social

 DESCRIPTION (provided by applicant): Currently we have multiple ongoing NIH funded studies at the University of Delaware (UD) to examine the effects of various behavioral interventions developed for pediatric and adult neurologically affected special populations. We feel there is an urgent need to understand the neural mechanisms of change underlying the behavioral improvements we notice in our populations of interest. Additionally, we are interested in studying the neural substrates for a wide range of behaviors that are an area of emphasis for NIH including working memory in children with Autism, interpersonal synchrony in children with Autism and Oppositional Defiant Disorder, balance in children with Cerebral Palsy, mobility in children with Down Syndrome, arm function in infants with Brain Injury, locomotion in patients with Stroke, and psychosocial symptoms related to Chronic Low Back Pain in older adults. In this proposal, we are requesting funds to purchase a Hitachi functional infrared spectroscopy (fNIRS) system (Model: ETG-4000) to advance our clinical and translational research programs as well as interdisciplinary collaborations between researchers working in the areas of pediatric/adult neurorehabilitation, developmental psychopathologies, and motor, social, and cognitive neuroscience. Common neuroimaging approaches such as functional Magnetic Resonance Imaging (fMRI) and electrophysiological approaches such as Electroencephalography (EEG) are limited to tasks in reclined or seated positions with minimal to no movement, making these applications ineffective in obtaining brain activation data in the presence of movement and during naturalistic interactions. If the fNIRS system were to become available at UD, it would allow us to examine part or whole brain activation during a variety of functional motor tasks such as reaching and walking as well as naturalistic and play-based interactions between individuals. This makes the fNIRS technology truly translational and transformational in understanding brain-behavior relationships within real-world settings when working with a diverse set of pediatric and adult special populations including Adult with Stroke and Chronic Low Back Pain, Children with Autism, Cerebral Palsy, Oppositional Defiant Disorder, and Down Syndrome as well as High-risk infants.

 描述（由适用提供）：目前，我们在特拉华大学（UD）进行了多项正在进行的NIH资助研究，以检查针对儿科和成人神经系统影响的特殊人群开发的各种行为干预措施的影响。我们认为迫切需要了解我们在感兴趣的人群中注意到的行为改善的改变的神经元机制。此外，我们有兴趣研究多种行为的神经元底物，这些行为是NIH的重点，包括自闭症儿童的工作记忆，自闭症和可选的反抗疾病的人际交往和可选的反抗疾病，儿童在患有大脑症状的儿童和脑损伤的患者中，患有症状的患者的运动能力和脑力相关的患者的流动性，脑损伤的患者，脑力下的症状和脑力相关的患者，脑性质的障碍，脑伴侣的运动能力，脑伴侣的症状，脑力不振，脑力下的症状症状，脑力相关，脑损伤的症状，在综合症患者中起作用。老年人的疼痛。在该提议中，我们要求资金购买日立功能性红外光谱（FNIRS）系统（模型：ETG-4000），以推动我们的临床和翻译研究计划以及在儿童神经治habialitic，发展心理学家，社交，社交，NEUROUST和MOTORITIVE，MOTORIVITION，MECORTIVIE，NEURESTIVE，NEUROUST和SEEMITIVE，NEURESTINIVE，MECORTIVIE，NEUROUSC中，研究人员之间的研究人员之间的跨学科合作。常见的神经影像学方法，例如功能磁共振成像（fMRI）和电生理学方法，例如脑电图（EEG）（EEG），仅限于在无运动的倾斜位置或座位位置的任务，这使得这些应用无效，使这些应用无效地在运动和自然互动中获得脑激活数据无效。如果FNIRS系统在UD上可用，它将使我们能够检查各种功能性运动任务期间的部分或整个大脑激活，例如到达和步行，以及个人之间的自然主义和基于游戏的相互作用。这使得FNIRS技术与现实世界中的脑行为关系真正转化和变革性，当时与一套小儿和成人特殊人群一起工作，包括中风和慢性下背部疼痛，自闭症儿童，脑瘫，可选的挑衅性疾病以及唐纳特综合症以及高风险的婴儿以及高风险的婴儿。

项目成果

fNIRS-Based Differences in Cortical Activation during Tool Use, Pantomimed Actions, and Meaningless Actions between Children with and without Autism Spectrum Disorder (ASD).

• DOI: 10.3390/brainsci13060876
• 发表时间: 2023-05-29
• 期刊: BRAIN SCIENCES
• 影响因子: 3.3
• 作者: Su, Wan-Chun;Culotta, McKenzie;Mueller, Jessica;Tsuzuki, Daisuke;Bhat, Anjana
• 通讯作者: Bhat, Anjana