BioSystems Networks and Translational Research - Insights into Inflammation (BioSNTR-II)

BioSystems 网络和转化研究 - 炎症洞察 (BioSNTR-II)

• 批准号: 10593066
• 负责人: Adam David Hoppe
• 金额: $ 218.46万
• 依托单位: SOUTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-20 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593066
• 关键词: Acceleration; Animals; Area; Bioinformatics; Biological Sciences; Biomedical Research; Biotechnology; CRISPR imaging; Cell Communication; Cell Death; Cell physiology; Cells; Center for Translational Science Activities; Centers of Research Excellence; Cilia; Clinic; Clustered Regularly Interspaced Short Palindromic Repeats; Communication; Cytokine Signaling; Development; Disease; Education; Environment; Evaluation; Event; Faculty; Fostering; Funding; Genes; Genetic Transcription; Genomics; Goals; Grant; Growth; Health; Human; Inflammation; Inflammatory; Inflammatory Response; Investments; Knowledge; Labor Forces; Lymphangiogenesis; Lymphatic; Macrophage; Macrophage Cell Biology; Mentors; Microscopy; Mission; Molecular; Optics; Pathway Analysis; Pathway interactions; Performance; Personnel Management; Pilot Projects; Plants; Private Sector; Process; Program Research Project Grants; Proteins; Proteomics; Public Health; Records; Regulation; Research; Research Personnel; Research Project Grants; Resolution; Resources; Role; Senior Scientist; Signal Transduction; South Dakota; TNF gene; Technology; Technology Transfer; Tissues; Training Support; Translational Research; Translations; Ubiquitin; United States National Institutes of Health; Universities; University adminstration; Work; career; cohort; experience; formative assessment; immune cell infiltrate; improved; innovation; insight; instrumentation; interdisciplinary approach; medical schools; model development; next generation sequencing; programs; research and development; senior faculty; success; synergism; tenure track; transcriptome; transcriptome sequencing; transcriptomics

PROJECT SUMMARY – OVERALL The goal of this proposal is a coordinated, synergized, and integrated COBRE research program, called the “BioSystems Networks and Translational Research – Insights into Inflammation (BioSNTR-II),” at South Dakota State University (SDSU), Brookings, SD. Our research objective is to improve human health by advancing the understanding of molecular, cellular and tissue-level mechanisms of inflammation research via multi-disciplinary approaches. The overarching hypothesis is that intracellular regulatory events are governed by cell-cell communication across the macrophage, stromal and lymphatic axes during the inflammatory response and its resolution. Junior research project leaders, mentored by senior faculty, define the three research projects of BioSNTR-II in the areas of: macrophage cell biology in inflammation, the role or primary cilia in regulating lymphangiogenesis in inflammation and regulation of tumor necrosis factor signaling and cell death pathways. These projects will be supported by two cutting-edge research cores in (1) transcriptome sequencing, analysis and model development (Transcriptome and Network Analyses Core) and (2) CRISPR- based gene editing and Integrated Microscopy and Gene Evaluation (CRISPR-IMAGE). In addition, an Administrative Core is proposed to support the fiscal and personnel management, implementation, oversight and evaluation of both the research projects and the cores. The synergy and integration of these components has been carefully planned to maximize impact while supporting training, professional development, and the career potential of a cadre of bright, promising basic researchers. The Center will achieve success through the following aims: (1) Develop and manage a thriving environment for inflammation research at SDSU, (2) Establish new Research Cores to expand and enhance biomedical research at SDSU, and (3) Guide center performance and sustainability with assessment and advisory board input.

项目摘要 - 总体 该提案的目的是协调，协同和综合的鞋底研究计划，称为The The “生物系统网络和转化研究 - 对炎症的见解（Biosntr-II）”，南方 达科他州立大学（SDSU），布鲁金斯，SD。我们的研究目标是通过 通过了解感染研究的分子，细胞和组织水平机制的理解 多学科方法。总体假设是控制细胞内调节事件 通过在巨噬细胞，基质和淋巴轴之间通过细胞 - 细胞通信在炎症过程中 响应及其解决方案。高级教师指导的初级研究项目领导者定义了三个 Biosntr-II在炎症中的巨噬细胞生物学领域的研究项目 纤毛在炎症和调节肿瘤坏死因子信号和细胞中的淋巴管生成方面 死亡道路。这些项目将由（1）转录组中的两个尖端研究核心支持 测序，分析和模型开发（转录组和网络分析核心）和（2）CRISPR- 基于基因编辑和综合显微镜和基因评估（CRISPR-图像）。另外，一个 建议行政核心支持财政和人员管理，实施，监督 以及对研究项目和核心的评估。这些组件的协同和整合 已经过精心计划，以最大程度地影响培训，专业发展和 一群聪明，有前途的基础研究人员的职业潜力。中心将通过 以下目的：（1）开发和管理SDSU感染研究繁荣的环境，（2） 建立新的研究核心，以扩展和增强SDSU的生物医学研究，（3）指南中心 绩效和可持续性通过评估和顾问委员会的投入。