Insectary for Scientific Training and Advances in Research (InSTAR)

昆虫科学培训和研究进展部 (InSTAR)

基本信息

批准号：
10237917
负责人：
PATRICIA A COUVILLON
金额：
$ 8.78万
依托单位：
UNIVERSITY OF HAWAII AT MANOA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10237917
关键词：
Age Biodiversity Biological Models Biomedical Research Cell physiology Centers of Research Excellence Chikungunya virus Collaborations Communicable Diseases Communities Containment Coordination and Collaboration Dengue Virus Development Disease Disease Outbreaks Disease Vectors Education Effectiveness Emerging Communicable Diseases Environment Environmental Impact Equipment Faculty Fostering Future Generations Genetically Modified Organisms Goals Hawaii Hawaiian population Health Health system Human Human Microbiome Immunity Infection Infectious Diseases Research Infrastructure Insecta Institution Intervention Invertebrates Investigation Laboratories Link Maintenance Mediating Medical Medical Entomology Metabolism Microbe Modeling Native Hawaiian Protocols documentation Public Health Radiation Research Research Personnel Research Support Resources Rift Valley fever virus Role Scrub Typhus Specimen System Time Training Universities Vertebrates West Nile virus Work Zika Virus biosafety level 2 facility experimental study fitness human disease immune function insect disease vector instrument microbial microbial genomics microbiome microbiota microscopic imaging oceanic research pathogen prevent research facility symbiont transgenic insect vector

项目摘要

Project Summary – CORE D: Insectary for Scientific Training and Advances in Research (InSTAR) Insects provide excellent model systems with which to study the interactions between hosts and their microbiota. These insect models advance our understanding of the impact of microbial symbionts on host development, metabolism, immune function, and overall system fitness, and produce generalizable information that informs human health. In addition, the symbiotic microbes of insects have direct impacts on public health because microbial symbionts influence the survival, development, cellular function, and immunity of insect pests and disease vectors that contribute significantly to the global public health burden, especially in the tropics. The central objective of this proposal is to develop an insectary facility that will enable the use of insects to study the environmental microbiome by researchers at the University of Hawai`i at Mānoa. Currently, this major research university does not have a high-containment biosafety level 2 (BSL-2) facility, which greatly reduces the capacity of researchers at this institution to utilize insect models to study the impact of the environmental microbiome on human health. The proposed Insectary for Scientific Training and Advances in Research (InSTAR) will provide such a high-containment, BSL-2 certified insectary space and greatly facilitate use of insect models to investigate biomedical questions that impact human health. Importantly, the InSTAR facility will provide critical infrastructure for at least four junior investigators on this COBRE, and will fully integrate with existing facilities at UHM that support a renowned community of researchers investigating the microbiome. Over the long term, the core will facilitate medical entomology in the State of Hawai`i, increasing the capacity to respond to public health threats imposed by insects. In addition, it will promote research toward developing new model systems focusing on unique native Hawaiian insects, and serve as a resource that facilitates access to Hawaii`s distinctive biodiversity to the global research community.

项目摘要 - 核心D：科学培训和研究进展的昆虫（INSTAR）昆虫提供了出色的模型系统，可利用研究宿主及其之间的相互作用微生物群。这些昆虫模型提高了我们对微生物符号对宿主的影响的理解开发，新陈代谢，免疫功能和整体系统健身，并产生了可推广的信息这为人类健康提供了信息。此外，昆虫的共生微生物对公共卫生有直接影响因为微生物符号会影响绝缘的生存，发育，细胞功能和免疫力害虫和疾病媒介对全球公共卫生的燃烧产生了重大贡献，尤其是在热带。该提案的核心目的是开发一种绝缘设施，以实现昆虫研究Mānoa夏威夷大学研究人员的环境微生物组。现在，这所主要的研究大学没有高管生物安全2级（BSL-2）设施，这是极大的降低了该机构研究人员利用绝缘模型来研究的能力人类健康的环境微生物组。拟议的昆虫进行科学训练和进步研究（Instar）将提供如此高的含量，BSL-2认证的绝缘空间，并大量托管使用昆虫模型研究影响人类健康的生物医学问题。重要的是，Instar 该设施将为这家cobre的至少四名初级调查员提供关键的基础设施，并将完全与UHM的现有设施集成，该设施支持一个著名的研究人员社区调查微生物组。从长远来看，核心将促进夏威夷州的医学昆虫学，增加应对昆虫施加的公共卫生威胁的能力。此外，它将促进研究开发针对独特本地夏威夷绝缘材料的新模型系统，并作为一种资源促进进入夏威夷的独特生物多样性进入全球研究界。