Insectary for Scientific Training and Advances in Research (InSTAR) Core

昆虫科学培训和研究进展 (InSTAR) 核心

• 批准号: 10712775
• 负责人: PATRICIA A COUVILLON
• 金额: $ 16.67万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712775
• 关键词: Address; Advocate; Affect; Agriculture; Arthropods; Award; Biodiversity; Biological; Biological Models; Biological Sciences; Biomedical Research; Blood; Breeding; Cell physiology; Centers of Research Excellence; Chikungunya virus; Collaborations; Collection; Communities; Containment; Core Facility; Culicidae; Dangerousness; Dengue Virus; Development; Disease Outbreaks; Disease Vectors; Drosophila genus; Drosophila melanogaster; Equipment; Fee-for-Service Plans; Food Webs; Food production; Funding; Generations; Goals; Grant; Hawaii; Hawaiian; Health; Health system; Home; Human; Human Microbiome; Immunity; Income; Infrastructure; Insect Vectors; Insecta; Institution; Institutionalization; Invertebrates; Laboratories; Link; Maintenance; Malaria; Mediating; Medical; Medical Entomology; Metabolism; Microbe; Modeling; Mosquito-borne infectious disease; Native Hawaiian; Pathway interactions; Phase; Procedures; Protocols documentation; Public Health; Recording of previous events; Research; Research Activity; Research Personnel; Research Support; Resources; Retirement; Role; Secure; Services; Structure; Study models; System; Taxus; Training; Universities; Vertebrates; West Nile virus; Work; Zika Virus; base; field study; fly; human pathogen; immune function; interest; medical schools; microbial; microbiome; microbiome research; microbiota; non-Native; pathogen; programs; sucking; symbiont; vector mosquito

PROJECT SUMMARY - Insectary for Scientific Training and Advances in Research (InSTAR) Invertebrates provide excellent model systems to study the interactions between hosts and their microbiota. These invertebrate models advance our understanding of the impact of microbial symbionts on host development, metabolism, immune function, and overall system health, and produce generalizable information that informs human health. In addition, the symbiotic microbes of invertebrates have direct impacts on public health as microbial symbionts influence the survival, development, cellular function, and immunity of pest species and disease vectors that contribute significantly to the global public health burden. The central objective of this proposal is to further develop a core facility that will enable the use of arthropods to study the environmental microbiome at the University of Hawai‘i at Mānoa. During Phase 1, the InSTAR established a unique collection of laboratory colonies for medically relevant mosquito vectors and Hawaiian Drosophila species, and established the only BSL-2/ACL-2 space to work with potentially dangerous insects in a laboratory setting in the state of Hawai‘i. The core also provided critical infrastructure for three former RPLs, and continues to support the independent research programs for two of those RPLs. During the next cycle of this CoBRE award, the InSTAR will i) provide infrastructure to support the research of two new Phase II RPLs, ii) establish a greater diversity of insect models in colony, with a special focus on Hawaiian Drosophila sp., iii) establish space to utilize for rearing only to allow a greater diversity of research activities in the non-rearing sections of the InSTAR core, and iv) coordinate with State, Federal, and academic groups to expand the InSTAR’s user base. Over the long term, the core will continue to facilitate medical entomology in the State of Hawai‘i, increasing the capacity to respond to public health threats imposed by invertebrates. In addition, it will promote research toward developing new model systems focusing on unique native Hawaiian invertebrate species, and serve as a resource that facilitates access to Hawaii‘s unique biodiversity to the global research community.

项目摘要 - 科学培训和研究进展的昆虫（INSTAR） 无脊椎动物提供了出色的模型系统来研究宿主与其微生物群之间的相互作用。 这些无脊椎动物模型可以提高我们对微生物符号对宿主的影响的理解 开发，新陈代谢，免疫功能和整体系统健康，并产生了可推广的信息 这为人类健康提供了信息。此外，无脊椎动物的共生微生物对公众有直接影响 健康作为微生物符号会影响害虫的生存，发育，细胞功能和免疫力 物种和疾病向量对全球公共卫生伯恩产生了重大贡献。中央 该提案的目的是进一步开发一个核心设施，该设施将使节肢动物能够研究 夏威夷大学Mānoa的环境微生物组。在第1阶段，Instar建立了 用于医学相关蚊子和夏威夷果蝇的独特实验室殖民地集合 物种，并建立了唯一的BSL-2/ACL-2空间，可以在A中使用潜在危险的绝缘材料 夏威夷州的实验室环境。核心还为三个以前的RPL提供了关键的基础架构， 并继续为其中两个RPL的独立研究计划提供支持。在下一个周期 这个鞋带奖，即i龄），我将提供基础架构，以支持两个新的II期RPL的研究， ii）在殖民地中建立更大的昆虫模型，特别关注夏威夷果蝇Sp。，iii） 建立用于饲养的空间，仅允许在非劳动中进行更多的研究活动 Instar Core的部分以及IV）与州，联邦和学术团体协调，以扩展 Instar的用户群。从长远来看，核心将继续促进医学昆虫学 夏威夷增加了对无脊椎动物施加的公共卫生威胁的反应能力。此外，它将 促进研究以开发针对独特夏威夷本地无脊椎动物的新模型系统 物种，并作为促进夏威夷独特生物多样性进入全球研究的资源 社区。