Visual-somatosensory integration as a novel marker of Alzheimer's disease

视觉体感整合作为阿尔茨海默病的新标志

基本信息

批准号：
10560644
负责人：
Jeannette R. Mahoney
金额：
$ 84万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-15 至 2027-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10560644
关键词：
Address Adverse effects Affect Aging Alzheimer&apos s Disease Alzheimer&apos s disease pathology Alzheimer&apos s disease patient Alzheimer&apos s disease related dementia Alzheimer&apos s disease risk Amyloid beta-Protein Area Area Under Curve Attention Basal Ganglia Behavioral Behavioral Model Brain Clinic Cognitive Communities Data Dementia Deposition Development Disease Disease Marker Disease Progression Elderly Equilibrium Experimental Designs Fostering Functional Magnetic Resonance Imaging Funding Future Gait Impaired cognition Individual Infrastructure Intervention Intervention Studies Investigation Link Longitudinal Studies Longitudinal cohort Longitudinal, observational study Magnetic Resonance Imaging Measures Mediating Memory Modality Motor National Institute on Alcohol Abuse and Alcoholism Neuroanatomy Neurobiology Neuropsychological Tests Outcome Parietal Participant Performance Peripheral Plasma Positron-Emission Tomography Prefrontal Cortex Process Reaction Time Recording of previous events Reporting Research Research Priority Resources Sensory Statistical Models Structure of superior frontal gyrus Thick Time United States National Institutes of Health Visual Work abeta accumulation blood oxygen level dependent cognitive function cognitive process disability fall risk falls functional independence innovation insight interest longitudinal design mild cognitive impairment motor disorder multisensory neural neural correlate neural network novel novel marker pre-clinical prevent recruit response sensory input sensory integration somatosensory therapy design

项目摘要

ABSTRACT Identification of novel, non-cognitive (i.e., sensory or motor), non-invasive markers of Alzheimer’s disease and related dementias are a national priority identified by the National Alzheimer Plan. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in memory function. Previous investigations have failed to examine the interplay and time course of sensory, cognitive, and motor dysfunction on the progression of Alzheimer’s disease. The ability to successfully integrate multisensory information across multiple sensory modalities is a vital aspect of functioning and mobility in the real world. Our research suggests that multisensory integration could be used as a novel marker for preclinical Alzheimer’s disease given reported associations between magnitude of visual-somatosensory integration and important cognitive (attention) and motor (balance, gait, and falls) outcomes. We have highlighted the adverse effects of dementia and mild cognitive impairment on these relationships, but the underlying functional and neuroanatomical networks remain to be uncovered. Identification of these functional networks is critical to guide development of future multisensory-based interventions to prevent non-cognitive outcomes such as falls in cognitively impaired individuals. Hence, we propose to recruit 208 community-dwelling older adults with and without preclinical Alzheimer’s disease (defined as impaired cognitive function on neuropsychological testing and presence of Aß in plasma) for a three-year longitudinal observational study. Our central hypothesis is that preclinical Alzheimer’s disease is associated with neural disruptions in subcortical and cortical areas that concurrently modulate multisensory, cognitive, and motor functions, resulting in mobility decline. Our strategic experimental design, which leverages existing longitudinal cohorts, aims to assess the validity of multisensory integration as a behavioral marker for preclinical Alzheimer’s disease. It also provides an opportunity to examine the integrative time course and interplay of individual sensory, motor, and cognitive processes (and their interactions) in preclinical Alzheimer’s disease. The proposed project addresses the NIH’s priority, as well as NIA’s special interest notice [NOT-AG-20-053]. This work will increase understanding of the neurobiology of Alzheimer’s disease and will guide future multisensory-based intervention studies that aim to alleviate disability and maintain independence in older adults with and without preclinical Alzheimer’s disease. 2

抽象的鉴定新型，非认知（即感觉或运动），阿尔茨海默氏病的非侵入性标记和相关痴呆症是国家阿尔茨海默氏症计划确定的国家优先事项。越来越多的证据表明在出现在神经区域之前参与内存功能。先前的调查未能检查关于阿尔茨海默氏病进展的感觉，认知和运动功能障碍。成功的能力跨多种感觉方式跨越的多感官信息是功能和移动性的重要方面在现实世界中。我们的研究表明，多感官一体化可以用作新的标记给出的临床前阿尔茨海默氏病报道了视觉感应的幅度之间的关联整合和重要的认知（注意）和运动（平衡，步态和跌倒）的结果。我们已经突出了痴呆症和轻度认知障碍对这些关系的不利影响，但基础功能和神经解剖网络仍有待发现。这些功能网络的识别是指导未来基于多感官的干预措施以防止非认知结果的至关重要随着认知受损的个体跌倒。因此，我们建议招募208个社区居住的老年人有和没有临床前阿尔茨海默氏病（定义为神经心理学的认知功能受损在血浆中进行Aß的测试和存在）进行了三年的纵向观察研究。我们的中心假设是临床前阿尔茨海默氏病与皮质下和皮质区域的神经干扰有关同时调节多感官，认知和运动功能，导致活动性下降。我们的策略利用现有纵向人群的实验设计旨在评估多感官的有效性作为临床前阿尔茨海默氏病的行为标记。它还提供了检查的机会单个感觉，运动和认知过程的综合时间课程和相互作用（及其临床前阿尔茨海默氏病的相互作用）。拟议的项目涉及NIH的优先事项，以及 NIA的特殊利息通知[NOT-AG-20-053]。这项工作将增加对神经生物学的理解阿尔茨海默氏病，并将指导未来的基于多感官的干预研究，旨在减轻残疾并在患有和没有阿尔茨海默氏症临床前的老年人中保持独立性。 2