Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities Framework

使用健康差异框架预测老年人中枢神经系统结构、功能和连接组学改变

基本信息

批准号：
10560592
负责人：
Ann D. Cohen
金额：
$ 237.15万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-02-15 至 2027-11-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10560592
关键词：
Address Adult Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk American Amyloid Amyloid beta-Protein Attention Attenuated Behavior Behavioral Biological Biological Markers Black Populations Black race Blood Pressure Brain Brain imaging Brain region Classification Cognition Cognitive Communication Communities Data Data Set Dementia Development Diagnostic Disadvantaged Education Elderly Evaluation Exercise Female Functional Magnetic Resonance Imaging Genotype Goals Health Disparities Research Human Image Impaired cognition Individual Inequity Influentials Institutionalization Laboratories Learning Magnetic Resonance Imaging Measures Modeling National Institute of Mental Health Natural History Neighborhoods Nerve Degeneration Not Hispanic or Latino Participant Pattern Phenotype Plasma Population Positron-Emission Tomography Poverty Process Research Research Personnel Risk Risk Factors Role Sampling Shapes Sleep Specific qualifier value Standardization Structure Target Populations Testing Thinking Time Tracer United States National Institutes of Health Vascular Diseases Visit Woman Work aging brain connectome contextual factors data archive experience follow-up health disparity health equity in vivo mind control modifiable risk multimodality neighborhood disadvantage neuropathology protective effect protective factors racial difference racial disparity racism recruit residential segregation segregation social culture social health determinants structural determinants tau Proteins tau-1 thought control vascular risk factor

项目摘要

Abstract The goal of this project is to leverage the diverse sample in our Human Connectome Project (HCP) Study, Connectomics in Brain Aging (COBRA) , to investigate the role(s) of structural and social determinants of health in the natural history of Alzheimer’s Disease (AD) utilizing a health equity framework. We propose that racial inequities in the development of cognitive impairments in the context of AD are driven by pervasive structural and institutionalized inequities that shape risk and disadvantage at multiple levels, including biological, environmental, behavioral, sociocultural, as proposed in the NIA Health Disparities Research Framework. Our organizing principle is that the expression of cognitive dysfunction in the elderly is the result of two independent processes affecting the connectome — the first is the neuropathology associated with AD. The second process historically has been referred to as “modifiable individual risk factors”, however, this fails to recognize that individual risk is influenced by factors that are outside of an individual’s control, and which will be measured using a health equity framework. We will augment our existing sample (50% Black, 65% Female) with an additional 150 participant (total sample ~400 with up to four study visits). Each of the participants will contribute the HCP-specified demographic, behavioral and laboratory data. All of the participants will undergo extensive brain imaging biannually including MRI and PET (amyloid and tau tracers). All of the MRI data will be uploaded to the Connectome Coordinating Facility, and the behavioral/cognitive, PET data will be uploaded to the NIMH Data Archive. Locally, we will use these data to address specific questions related to structure, function, AD, aging and vascular disease in multi-modality studies leveraging the differential advantages of MRI, fMRI, and in vivo Aβ and tau imaging.

抽象的该项目的目的是利用我们的人类Connectome项目（HCP）中的潜水员样本研究，脑衰老的连接组学（COBRA），以研究结构和社会决定者的作用使用健康公平框架的阿尔茨海默氏病（AD）自然史的健康。我们建议在AD背景下，认知障碍发展中的种族不平等是由普遍存在的结构性和制度化的不平等现象，这些不平等在多个层面上塑造风险和灾难，包括 NIA健康差异研究中提出的生物学，环境，行为，社会文化框架。我们的组织原则是，较早的认知功能障碍的表达是两个影响连接组的独立过程 - 第一个是与AD相关的神经病理学。从历史上看，第二个过程被称为“可修改的个人风险因素”，但是，这失败了认识到个人风险受到个人控制之外的因素的影响，哪些将可以使用健康平等框架进行测量。我们将增加现有样本（黑色50％，女性65％），另外150名参与者（总计样本〜400最多四次研究访问）。每个参与者将贡献HCP指定的人口，行为和实验室数据。所有参与者都会进行大脑成像一年一度包括MRI和PET（淀粉样蛋白和Tau示踪剂）。所有MRI数据将上传到 Connectome协调设施以及行为/认知，PET数据将上传到NIMH数据档案。在本地，我们将使用这些数据来解决与结构，功能，AD，老化有关的特定问题多模式研究中的血管疾病利用MRI，fMRI和体内的差异优势 Aβ和TAU成像。