Role of midlife cardiovascular disease on Alzheimer’s Pathology and cerebrovascular reactivity in the young-old.

中年心血管疾病对年轻老年人阿尔茨海默病病理学和脑血管反应性的作用。

基本信息

批准号：
9077314
负责人：
Ann D. Cohen
金额：
$ 65.73万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-15 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9077314
关键词：
Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease risk Amyloid Amyloid beta-Protein Amyloid deposition Area Arteriosclerosis Atherosclerosis Atrial Fibrillation Blood Vessels Brain Cardiovascular Diseases Cerebrovascular Circulation Clinical Clinical Markers Cognition Communities Coronary Arteriosclerosis Data Dementia Development Disease Disease Progression Elderly Evaluation Evaluation Studies Exhibits Failure Functional disorder Goals Heart Hypercapnia Hypertension Image Impaired cognition Incidence Individual Inflammation Link Lipids Longitudinal Studies Magnetic Resonance Imaging Measures Mediating Myocardial Ischemia Nerve Degeneration Participant Pathology Pathway interactions Peripheral Physiology Positron-Emission Tomography Prevalence Prevention Reporting Risk Risk Factors Role Spin Labels Structure Syndrome Therapeutic abeta deposition age related arterial stiffness base cardiovascular disorder risk cerebral atrophy cerebrovascular cognitive change cohort middle age non-demented post gamma-globulins pre-clinical public health relevance racial disparity research clinical testing response retention rate tau Proteins

项目摘要

DESCRIPTION (provided by applicant): The prevalence of Alzheimer's disease (AD) is closely related to the presence of cardiovascular disease (CaVD), understanding the relationship between amyloid-beta (Aβ) pathology and CaVD is critically important. The overarching goal of this study is to further the understanding of the relationship between AD pathology, including Aβ and tau pathology and neurodegeneration, cerebrovascular reactivity and midlife CaVD. To achieve these goals, we will utilize a group non-demented participants from an existing cohort from the ongoing community-based Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) study, a longitudinal study that began in 2003 with a cohort of 2000 participants (43% black) between the ages of 45-75 years at study entry and has collected a wealth of longitudinal vascular measures. We hypothesize that subclinical CaVD identified in midlife is associated with increased risk for Alzheimer's disease pathology expressed as amyloid deposition and neurodegeneration. These changes in brain structure would be associated with alterations in cognition both cross-sectionally and longitudinally. We further hypothesize that the change in cognition will result from a failure of vascular compensatory responses, marked by increases in regional cerebral blood flow and cerebrovascular reactivity.

描述（由适用提供）：阿尔茨海默氏病（AD）的患病率与心血管疾病（CAVD）的存在密切相关，了解淀粉样蛋白β（Aβ）病理学与CAVD之间的关系至关重要。这项研究的总体目标是进一步了解AD病理学之间的关系，包括Aβ和TAU病理学和神经退行性，脑血管反应性和中年CAVD。为了实现这些目标，我们将利用现有队列中的一个非痴呆参与者，从正在进行的基于社区的心脏策略专注于风险评估（HEART SCOCE）研究，这是一项纵向研究，2003年始于2003年的2000名参与者（43％的黑人），年龄在45-75岁之间，年龄在45-75岁之间，并收集了一项丰富的长期水平水管水平。我们假设在中年鉴定出的亚临床CAVD与表示为淀粉样蛋白沉积和神经变性的阿尔茨海默氏病病理的风险增加有关。这些大脑结构的变化将与横截面和纵向的认知改变有关。我们进一步假设，认知的变化将是由于血管补偿性反应的失败而导致的，这是区域脑血流和脑血管反应性的增加。