Inflammation-Induced CNS Glutamate as a Function of Depression in Middle Age

炎症引起的中枢神经系统谷氨酸与中年抑郁症的关系

基本信息

批准号：
10273670
负责人：
Ebrahim Haroon
金额：
$ 12.91万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-02-01 至 2021-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10273670
关键词：
Aging Anisotropy Anterior Axon Basal Ganglia Behavior Behavior assessment Behavioral Biological Markers Brain Brain region Brain-Derived Neurotrophic Factor C-reactive protein COVID-19 Cerebrospinal Fluid Chemical Shift Imaging Chemicals Chronic Cognition Creatine Cytokine Receptors Data Dementia Depressed mood Diffuse Diffusion Magnetic Resonance Imaging Exhibits Funding Glutamates Goals Hippocampus (Brain)Impairment Individual Inflammation Inflammatory Internal Capsule Lead Light Measures Mental Depression Myelin Neurons Parents Pathology Patients Performance Peripheral Pharmaceutical Preparations Plasma Proteins ROC Curve Radial Research Sampling Sensitivity and Specificity TNF gene Testing Time Wages aged base cingulate cortex cognitive function cognitive performance cognitive task cost cytokine depressed patient depressive cognitions depressive symptoms extracellular indexing middle age neurofilament parent project power analysis recruit statistics tractography white matter

项目摘要

PROJECT SUMMARY The aims and goals are similar to those proposed in the parent application. Briefly, we plan to measure 1) CNS glutamate using single voxel and chemical-shift, multivoxel, MRS, 2) microstructural white matter integrity using diffusion tensor imaging/tract-based spatial statistics and myelin mapping, 3) peripheral and central biomarkers of inflammation and 4) depressive symptoms and cognition in 65 medication-free depressed and 35 controls aged 35-65. A sample of 80 subjects (55 depressed, 25 controls) have already been studied. We propose support to recruit 10 more depressed and 10 more controlled subjects. Issues specific to this request: Our study has faced closure between the months of March-September 2020 due to COVID-19-related shutdown. However, all staff salaries have been paid in full due to understandable and compassionate reasons. We request recouping the salary paid for the past 7 months and restart up costs. The full impact of the study could be fully realized by augmenting the sample with 20 more patients – resulting in a completion sample of 100. We have provided power analysis in support of this conclusion.

项目概要简而言之，我们计划衡量 1) CNS。使用单体素和化学位移、多体素、MRS、2) 微结构白质完整性的谷氨酸使用数十个扩散器成像/基于束的空间统计和髓磷脂映射，3) 外周和中枢 65 名未接受药物治疗的抑郁症和 4) 抑郁症状和认知的生物标志物我们已经对 35 名年龄在 35-65 岁的对照者进行了研究，其中包括 80 名受试者（55 名抑郁症患者，25 名对照者）。建议支持招募 10 名更抑郁的受试者和 10 名更受控制的受试者。此请求的具体问题：我们的研究在 2020 年 3 月至 9 月期间面临结束由于与 COVID-19 相关的停工，所有员工的工资均已全额支付，这是可以理解的。以及出于同情心的原因，我们要求收回过去 7 个月支付的工资和重启费用。通过增加 20 名患者的样本，可以充分实现该研究的全部影响——结果在 100 个完整样本中。我们提供了功率分析来支持这一结论。