Neural Network Connectivity of Financial Capacity in Mild Cognitive Impairment

轻度认知障碍中财务能力的神经网络连接

基本信息

批准号：
10599409
负责人：
MILAP A NOWRANGI
金额：
$ 16.25万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-01 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10599409
关键词：
Activities of Daily Living Age Anisotropy Anterior Applications Grants Arithmetic Assessment tool Biological Biological Markers Biometry Brain Clinical Cognitive Cognitive Therapy Cognitive aging Coin Complex Data Decision Making Dementia Development Plans Diffusion Magnetic Resonance Imaging Dorsal Education Elder Abuse Elderly Exercise Exhibits Functional Magnetic Resonance Imaging Future Gender Goals Impaired cognition Impairment Individual Inferior frontal gyrus Insula of Reil Investments Judgment K-Series Research Career Programs Knowledge Lead Life Measurement Measures Mentored Patient-Oriented Research Career Development Award Methods Monitor Neurobehavioral Manifestations Neurobiology Neurocognitive Outcome Participant Patients Performance Persons Psychometrics Public Health Research Research Methodology Research Personnel Rest Risk Self-Help Devices Social outcome Statistical Data Interpretation Technical Expertise Techniques Technology Testing Training Victimization angular gyrus career career development cognitive neuroscience cohort daily functioning executive function functional disability high risk imaging modality impaired capacity insight instrument instrumental activity of daily living interest mild cognitive impairment multimodality neural network neuroimaging neuroimaging marker neuromechanism novel novel therapeutics payment preservation psychological outcomes public health relevance relating to nervous system research and development responsible research conduct skills treatment response white matter

项目摘要

PROJECT SUMMARY/ABSTRACT The candidate’s long-term career goal is to become an independent investigator whose research focuses on brain networks in patients with cognitive impairment with functional disability. Specifically, the candidate is focused on understanding neural network connectivity associated with the loss of financial capacity (FC) in mild cognitive impairment (MCI). The functional and structural connectivity of brain networks associated with impairment in basic (MCI-FCb) and complex (MCI-FCc) FC in MCI, however, are not well understood. Thus, the proposed application for the Mentored Patient-Oriented Research Career Development Award (K23) integrates the candidates, background, interests, and established technical skills in cognitive neuroscience and neuroimaging to understand brain connectivity in MCI-FCb and MCI-FCc compared to normal controls (NC). In accordance with the candidate’s career goals, the career development plan will focus on training in: 1) neurobiology decision-making; 2) advanced neuroimaging methods; 3) high-level skills for neuroimaging analysis and biostatistics; 4) the assessment and interpretation of executive function, and financial capacity; 5) the responsible conduct of research. The proposed research plan will focus on correlating diffusion tensor imaging (DTI) and resting state fMRI (rs-fMRI) measurements large-scale neurocognitive networks to cognitive and functional measures. The specific aims of the research are: 1) To examine how changes in integrated structural and functional connectivity measurements within the executive control network relative to other brain networks will differ between groups; and 2) To investigate associations between specific domains and tasks on the Financial Capacity Instrument to changes to large-scale network connectivity. These aims and general methods will be applied to three participant groups: 1) 30 age- and education-matched NC; 2) 30 MCI-FCc; 3) 30 MCI-FCb. The specific hypotheses to be tested are that: 1) The MCI-FCc group will exhibit decreased functional connectivity in the executive network and decreased white matter integrity in specific tracts within the inferior frontal gyrus, anterior insula, and dorsal and ventrolateral prefrontal cortical regions; 2) The angular gyrus, as a key node in the default mode network, will exhibit significantly decreased structural and functional connectivity in MCI-FCb compared to MCI-FCc; 3) Performance on tasks of basic arithmetic and monetary skills and bill payment will positively correlate with relative structural and functional connectivity of both the default mode network and salience network; 4) Complex tasks of financial capacity including financial conceptual knowledge and investment decision making will be strongly associated with loss of connectivity within prefrontal cortical regions of the executive control network. At the conclusion of the K award, the candidate will have assembled a well-characterized cohort of and insights obtained in the proposed study may lead to developing more effective cognitive therapies, instruments for assessments, and assistive technologies.

项目概要/摘要候选人的长期职业目标是成为一名独立调查员，其研究重点是具体来说，候选者是患有认知障碍和功能障碍的患者的大脑网络。专注于了解与轻度财务能力丧失 (FC) 相关的神经网络连接认知障碍 (MCI) 与相关的大脑网络的功能和结构连接。然而，MCI 中基本 (MCI-FCb) 和复杂 (MCI-FCc) FC 的损伤尚不清楚。拟议的以患者为导向的研究职业发展奖（K23）申请整合认知神经科学领域的候选人、背景、兴趣和既定技术技能与正常对照 (NC) 相比，通过神经影像了解 MCI-FCb 和 MCI-FCc 的大脑连接性。根据候选人的职业目标，职业发展计划将重点培训：1）神经生物学决策；2）先进的神经影像方法；3）高水平的神经影像技能；分析和生物统计；4）执行功能和财务能力的评估和解释；所提出的研究计划将集中于关联扩散张量。成像（DTI）和静息态功能磁共振成像（rs-fMRI）测量大规模神经认知网络到认知研究的具体目标是： 1）研究综合变化如何。执行控制相关网络内与其他大脑的结构和功能连接测量网络在不同组之间会有所不同；2）调查特定领域和任务之间的关联财务能力工具改变大规模网络连接这些目标和一般性。方法将应用于三个参与者组：1) 30 名年龄和教育程度匹配的 NC；2) 30 名 MCI-FCC；3) 30 名 MCI-FCb。要测试的具体假设是：1）MCI-FCc 组将表现出功能下降。执行网络的连通性和下丘脑内特定区域白质完整性的降低额回、前岛叶、背侧和腹外侧前额皮质区域；2) 角回，作为默认模式网络中的关键节点将表现出结构和功能连接性显着下降 MCI-FCb 与 MCI-FCCc 的比较；3) 基本算术和货币技能以及账单任务的表现；支付将与默认模式的相对结构和功能连接正相关 4）金融能力的复杂任务，包括金融概念知识投资决策与前额皮质内连接的丧失密切相关在 K 奖结束时，候选人将组装一个执行控制网络的区域。在拟议的研究中获得的充分表征的队列和见解可能会导致开发更有效的认知疗法、评估工具和辅助技术。