The Institute for Biomolecular Targeting

生物分子靶向研究所

• 批准号: 10271745
• 负责人: DEAN R MADDEN
• 金额: $ 246万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10271745
• 关键词: 2019-nCoV; Address; Antibodies; Area; Autophagocytosis; Award; Awareness; Binding; Biological; Businesses; Career Mobility; Centers of Research Excellence; Communities; Complex; Consult; Consultations; Core Facility; Cryoelectron Microscopy; Cystic Fibrosis; Development; Diabetes Mellitus; Disease; Drug Targeting; Extramural Activities; Faculty; Faculty Recruitment; Financial Support; Fostering; Foundations; Funding; Future; Generations; Goals; Grant; Home; Image; Immunologics; Infection; Infrastructure; Institutes; Investigation; Investments; Ion Channel; Malignant Neoplasms; Mass Spectrum Analysis; Membrane Fusion; Mentors; Metabolic Control; Microscope; Microscopy; Modeling; Molecular; Molecular Target; Neoplasm Metastasis; Pathology; Phase; Play; Postdoctoral Fellow; Production; Productivity; Program Reviews; Protein Biochemistry; Proteins; Recovery; Research; Research Institute; Research Personnel; Research Project Grants; Resources; Respiratory Tract Infections; Role; Schools; Scientist; Seasons; Series; Services; Signal Transduction; Subgroup; Targeted Research; Teacher Professional Development; Technology; Testing; Therapeutic; Time; Translations; Vaccines; Virus Diseases; Work; base; career; clinical practice; cohort; community building; cost; diversity and inclusion; drug development; experience; faculty research; faculty support; fascinate; forging; fundamental research; innovation; instrument; instrumentation; interest; knowledge translation; member; mid-career faculty; molecular imaging; new technology; novel therapeutic intervention; operation; pre-clinical; preclinical development; programs; protein expression; recruit; success; symposium; therapeutic target; tool; tumor progression

The Dartmouth Institute for Biomolecular Targeting (bioMT) infuses mechanistic investigations with a sophisticated awareness of disease pathology and therapeutic need, enhancing the quality of even the most fundamental research. At the same time, it helps orient mechanistic investigations towards long-term translational goals for complex diseases such as cancer and infections. In phase I, our progress was strong. All six of our research project leaders (RPL) with more than two years’ support have received R01-equivalent funding. Our cores provide unique protein biochemistry resources and ‘navigators’ to access microscopes campus-wide. Our cores and seminars have created a vibrant and interdisciplinary community. Here, we propose to deploy phase II COBRE and institutional program enrichment funds to build on this foundation and fill key gaps to prepare bioMT for the transition to sustainable COBRE independence. Aim 1 is to increase our cohort of funded bioMT investigators to fill strategic roles in our research landscape. Our two most recent RPLs (3–15 months’ support) are continuing into phase II, joined by two outstanding new hires. Their projects explore basic signaling and immunological mechanisms with potential relevance to therapeutic targets ranging from respiratory infections to cancer progression and metastasis, interconnected by shared scientific and technical interests. All receive guidance from dedicated mentoring dyads to assist in career advancement and independent extramural funding, and all receive support from responsive scientific cores offering state-of-the- art technologies directly relevant to their bioMT research projects. With institutional support, we will also hire five new faculty members, aligned with our theme of discovering and exploiting molecular targets, and selected to enhance thematic subgroups. As starting RPLs graduate, we will recruit new hires and other potential candidates for EAC consideration as replacements. Aim 2 is to enhance our core facilities and prepare them for a transition to COBRE independence during phase III. The cores are fully staffed and have invested heavily in phase I instrumentation. We will partner to add key new technologies based on user input, including parallel protein expression, mass spectrometry, advanced microscopy, and cryoEM. Cost-recovery models will be developed for incremental deployment in phase III to enable core financial independence. Aim 3 continues enriching our community, including mini-symposia and pilot awards to foster new multi-PI and program-project applications, which will contribute to core sustainability. Overall, these aims will leverage proven COBRE strategies – junior faculty hiring, extramural and academic mentoring, excellent administrative and scientific core support, and interdisciplinary community building – to enhance bioMT’s scientific impact in targeted areas of need. This will prepare us for the transition to phase III funding and ultimate independence as an interdisciplinary and nationally visible research institute, spanning three schools and 10 departments at Dartmouth and deeply connected to local centers and regional IDeA partners.

达特茅斯生物分子靶向研究所（BIOMT）注入机械研究 对疾病病理和疗法需求的认识柔和，甚至提高了最多的质量 基本研究。同时，它有助于实现长期的机械调查 复杂疾病的转化目标，例如癌症和感染。在第一阶段，我们的进步很强。 我们的所有六个研究项目负责人（RPL）获得了两年多的支持 资金。我们的核心提供独特的蛋白质生物化学资源和“导航器”来访问显微镜 在校园范围内。我们的核心和下水道创造了一个充满活力的跨学科社区。在这里，我们 提议部署第二阶段的毛病和机构计划丰富资金以建立在该基金会和 填补关键空白，以准备BioMT，以使其过渡到可持续的鞋垫独立性。目标1是增加我们的 资助的BIOMT研究人员队列，以填补我们的研究领域的战略角色。我们最近的两个 RPLS（3-15个月的支持）继续进入II阶段，并由两名出色的新员工加入。他们的项目 探索具有与治疗靶标的潜在相关性的基本信号传导和免疫机制 从呼吸道感染到癌症的进展和转移，由共同的科学和 技术兴趣。所有人都从专门的心理二元组获得指导，以协助职业发展和 独立的校外资金，所有人都得到了响应式科学核心的支持，提供了最先进的 艺术技术与其Biomt研究项目直接相关。在机构支持下，我们还将雇用 五位新教师与我们发现和利用分子目标的主题保持一致， 选择以增强主题亚组。作为开始RPLS毕业生，我们将招募新员工和其他 EAC考虑的潜在候选人作为替代品。目标2是增强我们的核心设施， 在第三阶段期间，它们准备过渡到毛的独立性。核心配备人员，有 大量投资于第一阶段的仪器。我们将伙伴根据用户输入添加关键的新技术， 包括平行蛋白表达，质谱法，晚期显微镜和冷冻。成本恢复 将开发模型以在第三阶段的增量部署中开发，以实现核心财务独立性。目的 3继续丰富我们的社区，包括迷你典型和试点奖，以促进新的Multi-Pi和 程序项目应用程序将有助于核心可持续性。总体而言，这些目标将利用 经过验证的山cor策略 - 初级教师招聘，壁外和学术心理，出色的行政 以及科学的核心支持和跨学科的社区建设 - 以增强BIOMT在 需要的目标领域。这将使我们为过渡到第三阶段资金和最终独立做好准备 作为跨学科和全国可见研究所，跨越了三所学校和10个部门 达特茅斯（Dartmouth），与当地中心和地区思想合作伙伴有着密切的联系。