Admin Core

管理核心

• 批准号: 10271621
• 负责人: DAVID M RAND
• 金额: $ 37.74万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10271621
• 关键词: Accountability; Administrative Coordination; Administrator; Advisory Committees; Award; Bioinformatics; Biological; Biology; Biomedical Research; Centers of Research Excellence; Communication; Communities; Computational Biology; Computational Molecular Biology; Computer Analysis; Computers; Data; Data Scientist; Discipline; Effectiveness; Engineering; Ensure; Evaluation; Evaluation Reports; Faculty; Funding; Future; Genomics; Goals; Grant; High Performance Computing; Hospitals; Human Biology; Individual; Infrastructure; Joints; Lead; Leadership; Learning; Medicine; Mentors; Methods; Peer Review; Phase; Pilot Projects; Program Evaluation; Program Sustainability; Public Health; Reporting; Research; Research Personnel; Research Project Grants; Resources; Schedule; Schools; Science; Services; Strategic Planning; Structure; Support Groups; Time; Universities; Visualization; base; biomedical informatics; career; career development; community building; computer science; computing resources; cost; faculty support; genomic data; human disease; interest; meetings; programs; recruit; skills; statistical center; success

PROJECT SUMMARY The goal of this Phase 2 COBRE for Computational Biology of Human Disease (CBHD) is to strengthen, expand, and sustain research programs focusing on computational approaches to the basic biology of human diseases. This involves support for faculty investigators that increases their competitiveness for peer-reviewed funding, as well as support for resources and infrastructure that enhances Brown’s broader biomedical research community. A key theme of this Center is to build upon the strengths of biomedical researchers whose individual questions may differ widely, but whose underlying analytical questions share common ground in computational analyses of large-scale genomic datasets that lead to discovery. The Administrative Core will lead, coordinate, and manage 1) the general activities of the Center including strategic planning, advisory committee meetings, fiscal accountability, regulatory compliance, communication, and reporting; 2) the career development activities of the junior investigators including the Research Projects and Pilot Project programs, mentoring activities, and the Computational Biology Core resource, and 3) activities that strengthen program sustainability including strategic partnerships, program integration, community building, program evaluation, and cost-center planning. The Administrative Core in Phase 2 will build upon the resources and infrastructure developed and implemented in Phase 1 with proven effectiveness. Brown University has invested heavily in facilities that generate data (e.g., the Genomics Core), the Center for Computation and Visualization (CCV) that maintains the super computer and staffs the Advanced Research Computing group that supports high performance computing, and research centers with targeted academic interests in biology and medicine. Our CBHD COBRE is distinct from research centers as the sole service Center focused on analysis of omics-enabled data. We will achieve the goals of strengthening and sustaining the COBRE in Phase 2 with the following Specific Aims. 1. Provide scientific leadership, administrative coordination, and fiscal management to support the continued integration, expansion and strengthening of the Center. 2. Provide junior faculty Project Leaders with research funding, career development mentoring, and computational resources to strengthen research competitiveness and achieve peer-reviewed, sustainably funded research programs. 3. Facilitate and ensure Center sustainability and responsiveness by integrative community building, establishing strategic collaborative partnerships, and responding to formative and summative program evaluation.

项目摘要 该阶段2毛线用于人类疾病计算生物学（CBHD）的目标是加强，扩展， 并维持重点介绍人类疾病基本生物学的计算方法的研究计划。 这涉及对教师调查人员的支持，这些调查员提高了他们在同行评审的资金中的竞争力，如 以及对资源和基础设施的支持，可以增强布朗更广泛的生物医学研究界。 这个中心的一个关键主题是建立生物医学研究人员的优势，他们的个人问题 可能会有很大的不同，但其潜在的分析问题在计算分析中具有共同点 大规模基因组数据集导致发现。行政核心将领导，协调和 管理1）该中心的一般活动，包括战略规划，咨询委员会会议，财政 问责制，法规合规性，沟通和报告； 2） 包括研究项目和试点项目计划，心理活动的初级调查人员以及 计算生物学核心资源和3）加强计划可持续性的活动包括策略 合作伙伴关系，计划集成，社区建设，计划评估和成本中心计划。 第2阶段的行政核心将建立在开发和实施的资源和基础架构的基础上 1阶段的有效性。布朗大学已经在生成数据的设施上进行了大量投资（例如 基因组核心），即计算与可视化中心（CCV），该中心维护超级计算机 以及支持高性能计算和研究的高级研究计算集团 具有针对生物学和医学的学术利益的中心。我们的CBHD Cobre与研究不同 作为唯一服务中心的中心，重点是分析启用OMIC的数据。我们将实现目标 以以下特定目的加强和维持2阶段的毛病。 1。提供科学 领导，行政协调和财政管理，以支持持续集成，扩展 并加强中心。 2。为初级教师项目负责人提供研究资金，职业 开发指导和计算资源以增强研究竞争力和成就 经过同行评审，可持续资助的研究计划。 3。促进并确保中心可持续性和 通过综合社区建设，建立战略合作伙伴关系以及 响应形成性和总结性计划评估。