Administrative/Coordination Core

行政/协调核心

基本信息

批准号：
10250341
负责人：
FRANK M LAFERLA
金额：
$ 20.57万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10250341
关键词：
Accountability Administrative Coordination Administrator Age-associated memory impairment Alzheimer&apos s Disease Alzheimer&apos s disease model Animal Disease Models Animal Model Animals Annual Reports Basic Science Bioinformatics Biological Markers Brain California Catalogs Clinical Research Collaborations Communication Communities Complement Coupled Data Dementia Development Discipline Disease Disease model Education Ensure Equipment and supply inventories Experimental Designs Faculty Fostering Funding Future Generations Goals Grant Home Individual Industry Institutes Laboratories Lead Leadership Memory impairment Mentors Methods Modeling Modification Mus Neurodegenerative Disorders Neurosciences Occupations Pathway interactions Pharmacology Phenotype Preclinical Testing Prevention Procedures Program Evaluation Program Research Project Grants Protocols documentation Reagent Recording of previous events Reproducibility of Results Research Research Personnel Resources Rodent Model Schedule Suggestion Technology Testing The Jackson Laboratory Therapeutic Time Tissue Banks Tissues Training Transact Translational Research United States National Institutes of Health Universities Vision Work aged aging brain cohesion data management design experience innovation insight invention meetings model development mouse model nervous system disorder neuroinflammation next generation novel novel therapeutics operation prevent programs success therapeutic candidate therapeutic development therapeutic target

Accountability Administrative Coordination Administrator Age-associated memory impairment Alzheimer&apos s Disease Alzheimer&apos s disease model Animal Disease Models Animal Model Animals Annual Reports Basic Science Bioinformatics Biological Markers Brain California Catalogs Clinical Research Collaborations Communication Communities Complement Coupled Data Dementia Development Discipline Disease Disease model Education Ensure Equipment and supply inventories Experimental Designs Faculty Fostering Funding Future Generations Goals Grant Home Individual Industry Institutes Laboratories Lead Leadership Memory impairment Mentors Methods Modeling Modification Mus Neurodegenerative Disorders Neurosciences Occupations Pathway interactions Pharmacology Phenotype Preclinical Testing Prevention Procedures Program Evaluation Program Research Project Grants Protocols documentation Reagent Recording of previous events Reproducibility of Results Research Research Personnel Resources Rodent Model Schedule Suggestion Technology Testing The Jackson Laboratory Therapeutic Time Tissue Banks Tissues Training Transact Translational Research United States National Institutes of Health Universities Vision Work aged aging brain cohesion data management design experience innovation insight invention meetings model development mouse model nervous system disorder neuroinflammation next generation novel novel therapeutics operation prevent programs success therapeutic candidate therapeutic development therapeutic target

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项目摘要

The NexGen Alzheimer's Disease Models Center (NG-ADMC) will be administratively housed within the University of California, Irvine Institute for Memory Impairments and Neurological Disorders (UCI MIND). This Organized Research Unit at UCI administers the NIH funded ADRC, an Alzheimer's disease focused NIH Program Project Grant, an NIA Training Grant, and multiple other grants, requiring coordination of multiple investigators and multiple disciplines to achieve objectives that will transform the future. The Administrative/Coordination Core (ACC) of the NexGen Alzheimer's Disease Models Center will provide coordination of the entire Center and ensure fiscal accountability. Drs. LaFerla and Tenner have collaborated on multiple projects at UCI with complementing expertise in animal models, neuroinflammation, and therapeutic targetings. A Center Administrator with extensive administrative experience, as well as laboratory technical and management experience, will oversee daily transactions, organize routinely scheduled meetings, and contribute to fiscal planning and execution The Steering Committee will be convened at least every two months to review data and discuss any modification in procedures, direction, or priorities to facilitate the progress across the Center. The External Advisory Board will be convened every six months with the Steering Committee to affirm or modify Center activities toward achieving milestones of the multiple units. Importantly, a Project Manager who is knowledgeable about the various phenotype characterizations and experimental design will oversee the day-to-day placement of mice, including the efficient use of aged animals among the Center investigators. In addition, the Manager will maintain the catalog and inventory of the tissue repository, provide access to reagents/tissues under the guidance of the Co-PIs, and coordinate animal transfers to The Jackson Laboratory (JAX). The ACC will lead Center program evaluation activities, including annual reports of each core, and ensure communication among the units to accelerate progress toward achieving milestones. The ACC will communicate Center activities with the NIH Program Official and implement suggestions received from the NIH and the EAB.

Nexgen Alzheimer疾病模型中心（NG-ADMC）将在行政上安置加利福尼亚大学尔湾记忆障碍与神经系统疾病研究所（UCI心理）。这 UCI的有组织的研究部门管理NIH资助的ADRC，ADRC是阿尔茨海默氏病的NIH 计划项目赠款，NIA培训补助金以及其他多项赠款，需要多个协调调查人员和多个学科，以实现将改变未来的目标。这 Nexgen阿尔茨海默氏病模型中心的行政/协调核心（ACC）将提供整个中心的协调并确保财政责任。博士。 Laferla和Tenner合作在UCI的多个项目上，具有动物模型，神经炎症和治疗靶标。具有丰富管理经验的中心管理员以及实验室技术和管理经验，将监督日常交易，组织计划的会议，并为财政计划和执行做出贡献，指导委员会将至少每两个召集几个月来审查数据并讨论程序，方向或优先事项的任何修改，以促进在整个中心进行进展。外部顾问委员会将每六个月召集一次转向委员会确认或修改中心活动，以实现多个单位的里程碑。重要的是，对各种表型特征和实验性特征知识渊博的项目经理设计将监督小鼠的日常安置，包括有效地使用老年动物中心调查人员。此外，经理将维护组织存储库的目录和清单，在Co-Pis的指导下提供对试剂/组织的访问，并协调动物转移到杰克逊实验室（JAX）。 ACC将领导中心计划评估活动，包括每个核心，并确保单位之间的沟通加速进步，以实现里程碑。 ACC将与NIH计划的官员进行中心活动，并实施收到的建议来自NIH和EAB。