Nebraska Center for Integrated Biomolecular Communication (CIBC)

内布拉斯加州综合生物分子通讯中心 (CIBC)

• 批准号: 10271829
• 负责人: Jiantao Guo
• 金额: $ 145.26万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10271829
• 关键词: Address; Area; Award; Bioinformatics; Biological; Biological Sciences; Biomedical Research; Biosensing Techniques; CARTPT gene; Cells; Chemicals; Chromatin; Collaborations; Communication; Communities; Complex; Computer Models; Core Facility; Cryoelectron Microscopy; Data; Data Analyses; Data Science; Detection; Development; Diagnosis; Discipline; Disease; Disease Pathway; E-learning; Educational workshop; Engineering; Equipment; Evaluation; Faculty; Fostering; Fourier transform ion cyclotron resonance; Funding; Genetic Transcription; Goals; Grant; Interdisciplinary Communication; Interdisciplinary Study; International; Knowledge; Mass Spectrum Analysis; Medical center; Metabolic Pathway; Methodology; Methods; Molecular; Molecular Probes; Mutation; Nature; Nebraska; Outcome; Outcomes Research; Pathway interactions; Peer Review; Peptide Receptor; Peptides; Phase; Physiological; Pilot Projects; Positioning Attribute; Problem Solving; Publications; Regulation; Regulatory Pathway; Research; Research Activity; Research Infrastructure; Research Personnel; Research Support; S Phase; Secure; Seeds; Series; Services; Statistical Data Interpretation; System; Systems Biology; Techniques; Technology; Time; Training; Universities; Water; base; career development; cohort; college; computational platform; data management; data mining; data portal; data sharing; design; human disease; imaging capabilities; improved; innovation; member; methicillin resistant Staphylococcus aureus; multidisciplinary; new technology; novel; novel therapeutic intervention; pathogen; recruit; structural biology; success; training opportunity; treatment strategy; unnatural amino acids

PROJECT SUMMARY/ABSTRACT Regulation of biomolecular communication pathways is critical to maintaining physiological function. Unraveling these pathways and filling in critical knowledge gaps will provide novel opportunities to understand, diagnose, and treat human diseases. During Phase 1, the Nebraska Center for Integrated Biomolecular Communication (CIBC) supported 15 early stage investigators (ESIs), helped recruit four new faculty members to the University of Nebraska-Lincoln (UNL), and established two research cores. CIBC’s ESIs secured $16.7 million in external research funds and authored 82 peer-reviewed publications. Building on Phase 1, the goal of the CIBC in Phase 2 is to continue building a critical mass of biomedical investigators and supporting research infrastructure in the area of biomolecular communication pathways at UNL that will position CIBC for a successful transition to long- term sustainability in Phase 3. CIBC will continue to develop multidisciplinary teams to interrogate complex disease pathways, especially by connecting researchers developing new molecular probes and analytical techniques with those unravelling molecular mechanisms of human diseases. CIBC’s Phase 2 specific aims are to: 1) strengthen UNL’s biomedical research infrastructure by supporting the research efforts and career development of biomedical investigators whose research is broadly focused on understanding the regulation of biomedically relevant communication pathways; 2) enhance research capabilities by maintaining and expanding the Systems Biology Core (SBC) to facilitate acquisition of essential bioanalytical data and the Data and Life Sciences Core (DLSC) to provide critical bioinformatics support and data management, storage, and sharing to Center members; and 3) advance interdisciplinary research collaborations with broad disciplinary representation to pursue high-impact research into complex disease from diverse perspectives. The initial Phase 2 Project Leaders will pursue projects interrelated by their fundamental focus on different aspects of the biomolecular basis of disease-associated communication pathways. These projects, which signify CIBC’s interdisciplinary nature, are directed toward: 1) developing novel chemical probes and targeted mass spectrometry approaches to study the cocaine and amphetamine-regulated transcript peptide and receptor(s), 2) understanding how the 7SK RNP regulates transcription and its implications in human diseases, 3) conducting near real-time detection of methicillin-resistant S. aureus by developing a generalizable electrochemical peptide-based biosensing platform, and 4) developing a novel Unnatural Amino Acid-based Chromatin Isolation Method (UChIMe) with improved accuracy and sensitivity. CIBC will further expand SBC and DLSC to enable Nebraska’s biomedical researchers to pursue high-impact biomedical research. CIBC’s innovation is in integrating the research activities of chemists, biochemists, engineers, and bioinformaticians to understand how cells communicate and integrate metabolic and regulatory pathways relevant to disease development and progression.

项目摘要/摘要 生物分子通信途径的调节对于维持生理功能至关重要。解开 这些途径和填补关键知识差距将为理解，诊断， 并治疗人类疾病。在第1阶段，内布拉斯加州综合生物分子通信中心 （CIBC）支持15名早期调查员（ESI），帮助招募了四名新教师到该大学 内布拉斯加州 - 林肯（UNL），并建立了两个研究核心。 CIBC的ESI为外部获得了1670万美元 研究资金并撰写了82个同行评审的出版物。在第1阶段建立CIBC的目标 2是继续建立大量的生物医学研究人员，并支持研究基础设施 UNL处的生物分子通信途径的区域将使CIBC成功过渡到长期 第3阶段的可持续性。CIBC将继续发展多学科团队以询问复杂 疾病途径，尤其是通过连接研究新分子问题和分析的研究人员 具有人类疾病的分子机制的技术。 CIBC的第二阶段特定目标 是：1）Strong Unl的生物医学研究基础设施通过支持研究工作和职业 生物医学研究人员的开发，其研究主要集中于了解调节 与生物医学相关的交流途径； 2）通过维护和扩展来增强研究能力 系统生物学核心（SBC）促进基本生物分析数据和数据和生活 科学核心（DLSC）提供关键的生物信息学支持和数据管理，存储和共享 中心成员； 3）提前学科的跨学科研究合作，具有广泛的纪律代表 从潜水员的角度来追求对复杂疾病的高影响研究。初始第2阶段项目 领导者将购买与生物分子不同方面的基本关注相关的项目 与疾病相关的沟通途径的基础。这些项目，表示CIBC的跨学科 大自然，针对以下方面：1）发展新的化学问题和靶向质谱法 研究可卡因和苯丙胺调节的转录本肽和接收器（S），2） 7SK RNP调节转录及其对人类疾病的影响，3）进行接近实时检测 通过开发可推广的基于电化学肽的生物传感的耐甲氧西林金黄色葡萄球菌的 平台和4）开发一种新型的非天然氨基酸染色质分离方法（UCHIME） 提高了准确性和灵敏度。 CIBC将进一步扩展SBC和DLSC以启用内布拉斯加州的生物医学 研究人员纯化高影响力生物医学研究。 CIBC的创新在于整合研究活动 化学家，生物化学家，工程师和生物信息学家，以了解细胞如何进行通信和整合 与疾病发展和进展有关的代谢和调节途径。