Alternating Current Electrolysis for Organic Synthesis

有机合成交流电解

• 批准号: 10273248
• 负责人: Long Luo
• 金额: $ 34.75万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10273248
• 关键词: Chemicals; Chemistry; Drug Industry; Drug usage; Electricity; Electrolyses; Electrolytes; Electrons; Engineering; Environment; Goals; Libraries; Methodology; Methods; Organic Synthesis; Oxidation-Reduction; Pharmacologic Substance; Power Sources; Production; Reaction; Safety; Vision; chemical reaction; cost; drug synthesis; voltage; wasting

PROJECT SUMMARY With growing concerns regarding the environment and sustainability, there is an increasing demand for integrating green chemistry and green engineering into the pharmaceutical industry. Electrochemical organic synthesis represents a green and advantageous alternative to traditional synthetic methods because it directly uses electrons from a power source to complete the redox transformations, which can cut down on the usage of chemicals, reduce waste, and offer improvements in cost, safety, and sustainability. However, the current reaction library of electrosynthetic methods is limited. Therefore, there is a critical need for new electrolytic methods that offer new chemical reactivities. The proposal is focused on studying the mostly unexplored alternating current electrolysis for organic synthesis. Unlike the conventional electroorganic synthetic methods using a constant voltage or current, alternating current electrolysis uses an alternating voltage to drive the redox transformations of substrates. Alternating current electrolysis offers a unique reaction environment where two redox-opposite reactions can occur spatially and temporally close to each other and can be easily adjustable by merely controlling the alternating current voltage supply. The overall goal of this proposal is to exploit this unique reaction environment of alternating current electrolysis to achieve new reactivities that are not currently accessible by the existing synthetic methodologies, serving as a critical step towards the long-term vision of the electrically driven green synthesis of drugs.

项目摘要 随着对环境和可持续性的越来越关注，越来越多 将绿色化学和绿色工程纳入制药行业的需求。 电化学有机合成代表了传统的绿色且有利的替代品 合成方法是因为它直接使用来自电源的电子来完成氧化还原 可以减少化学物质的使用，减少废物并提供的转换 成本，安全和可持续性的改善。但是，当前的反应库 电合成方法有限。因此，需要新的电解方法 那提供了新的化学反应性。 该提案的重点是研究主要未开发的交替电解电解 有机合成。与常规的电机合成方法不同，使用常数 电压或电流，交替电流使用交替电压驱动氧化还原 基材的转换。交替电流电解提供了独特的反应 两个可以在空间和时间上发生两个氧化还原 - 洲际反应的环境 其他，只需控制交替的电流电源即可轻松调节。 该提案的总体目标是利用这种独特的反应环境 当前的电解以实现现有的新反应率 合成方法，是迈向电视长期视觉的关键一步 驱动的药物绿色合成。