Cannabis and Nicotine Co-Use Influences on Protracted Development of Neural Structure and Function

大麻和尼古丁共同使用对神经结构和功能的长期发育的影响

基本信息

批准号：
10274472
负责人：
Joanna Jacobus
金额：
$ 67.09万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10274472
关键词：
19 year old 2-arachidonylglycerol Adolescent Adult Age Alcohol consumption Animal Model Anisotropy Architecture Attention Attitude Axon Behavior Behavioral Biological Assay Blood Blood Vessels Brain Cannabis Cerebrovascular Circulation Characteristics Chronic stress Cognition Cognitive Coupled Development Disease Emotional Endocannabinoids Enrollment Environment Fiber Frequencies Health Health behavior Human Hyperactivity Individual Intervention Interview Laboratories Learning Magnetic Resonance Imaging Magnetoencephalography Measurement Measures Mediating Mental Health Metabolic Methods Modality Myelin Neurites Neurobiology Neurocognition Neurocognitive Neurosciences Nicotine Outcome Participant Pattern Perception Perfusion Persons Play Predisposition Prevention Prevention program Psychopathology Public Health Public Policy Regulation Reporting Research Resolution Rest Restriction Spectrum Imaging Rewards Risk Role Sampling Serum Severities Signal Transduction Spin Labels Stress Structure Substance Use Disorder Symptoms Synapses System Techniques Tetrahydrocannabinol Thick Tissues Tobacco Tobacco Industry Tobacco use Visit Vulnerable Populations Youth addiction behavioral outcome blood perfusion brain health cognitive control cognitive testing craving density emerging adult emotional distress endogenous cannabinoid system follow-up frontal lobe gray matter health assessment indexing innovation intervention program marijuana use marijuana user multimodality negative affect neural correlate neurodevelopment neuroimaging nicotine use novel peer pre-clinical preventive intervention product development prospective receptor recruit relating to nervous system social substance use substance user tobacco products vaping nicotine white matter young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The distinctive effects of combined nicotine and tobacco product (NTP) and cannabis use on neuromaturational brain changes is unknown despite preclinical evidence of a functional interaction between delta-9-tetrahydrocannabinol (THC) and nicotine in the brain that may enhance susceptibility to the development of problematic substance use patterns and addiction severity symptoms. As cannabis becomes more socially accepted and accessible and nicotine delivery methods become more advanced and widespread among emerging adults, the neurobiological effects of co-use of these two substances during young adulthood must be better understood. The primary objective of the proposed prospective research is to recruit a sample of emerging adults (N=200) ages 18-19 at enrollment for three in-person assessments over three years, and a follow-up behavioral interview four years post-enrollment. At enrollment, participants will report either concurrent and simultaneous cannabis and NTP co-use, cannabis use only, NTP use only, and minimal to no use of either substance to compare how cannabis and nicotine use trajectories influence: (1) structural, vascular, and functional brain integrity, (2) neurocognition, (3) stress, emotional distress, and substance use, and (4) circulating endocannabinoid concentrations in blood serum. The study will use cutting-edge neuroimaging techniques (restriction spectrum imaging, pseudo-continuous arterial spin labeling, and high-resolution magnetoencephalography), cognitive testing, bioassays, and detailed mental health assessments at all in- person visits for a more precise understanding of the unique and combined effects of cannabis and NTP use on neural health, behavior, and the endocannabinoid system from ages 18-25 years-old. Young adults are one of our most vulnerable populations (e.g., high peak substance use rates, high vulnerability for addiction, high susceptibility to peer use attitudes and perceptions). As a result, they are specifically targeted by the cannabis and tobacco industry, particularly as the regulatory environment continues to become increasingly permissive for cannabis products. Yet, there is a remarkable paucity of research examining co-use of these two commonly used substances on neural health and neurocognitive functioning in emerging adults. The proposed research will lead to a greater understanding of the unique and combined effects of these substances on protracted brain development and risk for substance use disorders, which will guide neuroscience-informed prevention and intervention programs, public health messages, and public policy.

项目摘要/摘要尼古丁和烟草产物（NTP）以及大麻使用的独特作用对尽管临床前证据表明在大脑中的Delta-9-四氢大麻酚（THC）和尼古丁可能会增强对易感性的敏感性发展有问题的物质使用模式和成瘾严重性症状。随着大麻的变化更加社会接受和访问和尼古丁的传递方法变得更加先进和广泛在新兴的成年人中，这两种物质在成年期间共同使用的神经生物学影响必须更好地理解。拟议的前瞻性研究的主要目的是招募新兴成年人样本（n = 200）在入学率的18-19岁时进行了三年的三个面对面评估，并进行后续行为面试后四年。入学时，参与者将同时报告和同时报告大麻和NTP共同使用，仅使用大麻，仅使用NTP，并且最少不使用任何两种物质比较大麻和尼古丁的使用轨迹如何影响：（1）结构，血管和功能性大脑完整性，（2）神经认知，（3）压力，情绪困扰和药物使用，（4）循环血清中的内源性大麻素浓度。该研究将使用尖端的神经影像技术（限制光谱成像，伪连续的动脉自旋标记和高分辨率磁脑摄影），认知测试，生物测定和详细的心理健康评估人访问以更精确地理解大麻和NTP的独特效果关于18-25岁的神经健康，行为和内源性大麻素系统。年轻人是我们最脆弱的人群之一（例如，高峰值物质使用率，高成瘾的脆弱性，对同伴使用态度和感知的高敏感性）。结果，它们是大麻和烟草业的专门针对的是，特别是随着监管环境的继续变得越来越允许大麻产品。但是，研究很少检查这两种关于神经健康和神经认知功能的常用物质的共同使用新兴的成年人。拟议的研究将使人们对独特和合并的更多了解这些物质对大脑发育的影响和物质使用障碍的风险，这将指导神经科学知识的预防和干预计划，公共卫生信息和公共政策。