Cannabis and Nicotine Co-Use Influences on Protracted Development of Neural Structure and Function

大麻和尼古丁共同使用对神经结构和功能的长期发育的影响

基本信息

批准号：
10468171
负责人：
Joanna Jacobus
金额：
$ 60.5万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-15 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10468171
关键词：
19 year old 2-arachidonylglycerol Adolescent Adult Age Alcohol consumption Animal Model Anisotropy Architecture Attention Attitude Axon Behavior Behavioral Biological Assay Blood Blood Vessels Brain Cannabis Cerebrovascular Circulation Characteristics Chronic stress Cognition Cognitive Coupled Development Disease Emotional Endocannabinoids Enrollment Environment Fiber Frequencies Health Health behavior Human Hyperactivity Individual Intervention Interview Laboratories Learning Magnetic Resonance Imaging Magnetoencephalography Measurement Measures Mediating Mental Health Metabolic Methods Modality Myelin Neurites Neurobiology Neurocognition Neurocognitive Neurosciences Nicotine Outcome Participant Pattern Perception Perfusion Persons Play Predisposition Prevention Prevention program Psychopathology Public Health Public Policy Regulation Reporting Research Resolution Rest Restriction Spectrum Imaging Rewards Risk Role Sampling Serum Severities Signal Transduction Stress Structure Substance Use Disorder Symptoms Synapses System Techniques Tetrahydrocannabinol Thick Tissues Tobacco Tobacco Industry Tobacco use Visit Vulnerable Populations Youth addiction arterial spin labeling behavioral outcome blood perfusion brain health cognitive control cognitive testing craving density emerging adult emotional distress endogenous cannabinoid system follow-up frontal lobe gray matter health assessment indexing innovation intervention program marijuana use marijuana user multimodal neuroimaging negative affect neural correlate neurodevelopment neuroimaging nicotine use novel peer pre-clinical preventive intervention product development prospective receptor recruit relating to nervous system social substance use substance user tobacco products vaping nicotine white matter young adult

项目摘要

PROJECT SUMMARY/ABSTRACT The distinctive effects of combined nicotine and tobacco product (NTP) and cannabis use on neuromaturational brain changes is unknown despite preclinical evidence of a functional interaction between delta-9-tetrahydrocannabinol (THC) and nicotine in the brain that may enhance susceptibility to the development of problematic substance use patterns and addiction severity symptoms. As cannabis becomes more socially accepted and accessible and nicotine delivery methods become more advanced and widespread among emerging adults, the neurobiological effects of co-use of these two substances during young adulthood must be better understood. The primary objective of the proposed prospective research is to recruit a sample of emerging adults (N=200) ages 18-19 at enrollment for three in-person assessments over three years, and a follow-up behavioral interview four years post-enrollment. At enrollment, participants will report either concurrent and simultaneous cannabis and NTP co-use, cannabis use only, NTP use only, and minimal to no use of either substance to compare how cannabis and nicotine use trajectories influence: (1) structural, vascular, and functional brain integrity, (2) neurocognition, (3) stress, emotional distress, and substance use, and (4) circulating endocannabinoid concentrations in blood serum. The study will use cutting-edge neuroimaging techniques (restriction spectrum imaging, pseudo-continuous arterial spin labeling, and high-resolution magnetoencephalography), cognitive testing, bioassays, and detailed mental health assessments at all in- person visits for a more precise understanding of the unique and combined effects of cannabis and NTP use on neural health, behavior, and the endocannabinoid system from ages 18-25 years-old. Young adults are one of our most vulnerable populations (e.g., high peak substance use rates, high vulnerability for addiction, high susceptibility to peer use attitudes and perceptions). As a result, they are specifically targeted by the cannabis and tobacco industry, particularly as the regulatory environment continues to become increasingly permissive for cannabis products. Yet, there is a remarkable paucity of research examining co-use of these two commonly used substances on neural health and neurocognitive functioning in emerging adults. The proposed research will lead to a greater understanding of the unique and combined effects of these substances on protracted brain development and risk for substance use disorders, which will guide neuroscience-informed prevention and intervention programs, public health messages, and public policy.

项目概要/摘要尼古丁与烟草制品 (NTP) 和大麻混合使用对人体的独特影响尽管临床前证据表明神经成熟性大脑变化之间存在功能相互作用，但神经成熟性大脑变化尚不清楚大脑中的 delta-9-四氢大麻酚 (THC) 和尼古丁可能会增强对烟草的敏感性出现有问题的物质使用模式和成瘾严重症状。随着大麻变得更被社会接受和使用，尼古丁输送方法变得更加先进和广泛在新兴成年人中，青年期同时使用这两种物质的神经生物学影响必须得到更好的理解。拟议的前瞻性研究的主要目标是招募新兴成年人样本（N = 200）入学时年龄为 18-19 岁，在三年内进行三次现场评估，并进行后续行为评估入学四年后面试。在注册时，参与者将报告并发和同步大麻和 NTP 共同使用、仅使用大麻、仅使用 NTP、以及最少或不使用任何一种物质比较大麻和尼古丁的使用轨迹如何影响：(1) 大脑结构、血管和功能完整性，(2) 神经认知，(3) 压力、情绪困扰和物质使用，以及 (4) 循环血清中内源性大麻素的浓度。该研究将使用尖端的神经影像技术（限制光谱成像、伪连续动脉自旋标记和高分辨率脑磁图）、认知测试、生物测定和详细的心理健康评估人员访问，以更准确地了解大麻和 NTP 使用的独特和综合影响 18-25 岁的神经健康、行为和内源性大麻素系统。年轻人是我们最脆弱的人群之一（例如，高峰值物质使用率、高容易上瘾，对同伴使用态度和看法高度敏感）。结果，他们是大麻和烟草行业的具体目标，特别是随着监管环境的持续对大麻产品越来越宽容。然而，研究却显着缺乏检查这两种常用物质的共同使用对神经健康和神经认知功能的影响新兴成年人。拟议的研究将导致对独特和组合的更深入的了解这些物质对长期大脑发育的影响和物质使用障碍的风险，这将指导基于神经科学的预防和干预计划、公共卫生信息和公共政策。