Impact of Music Improvisation Training on Brain Function and Cognition among Older Adults

音乐即兴训练对老年人大脑功能和认知的影响

基本信息

批准号：
10274534
负责人：
JULENE K JOHNSON
金额：
$ 55.85万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-15 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10274534
关键词：
Address Adherence Adult Affect Age Aging Alzheimer&apos s disease related dementia Attention Behavior Behavioral Behavioral Mechanisms Biological Biological Assay Brain Brain imaging Cognition Cognitive Complex Creativeness Data Dementia Educational Intervention Elderly Emotions Generations Goals Health Health behavior Image Impaired cognition Informal Social Control Intervention Intervention Studies Language Lateral Learning Limb structure Link Maintenance Measures Memory Methods Monitor Motor Music Nature Neuronal Plasticity Outcome Patient Self-Report Personal Satisfaction Phase Pilot Projects Play Randomized Reading Research Risk Risk Factors Roter Self Efficacy Short-Term Memory Site Structure Techniques Testing Thinking Time Training Training Technics United States United States National Institutes of Health acceptability and feasibility arm attentional control base behavior change cognitive control cognitive function comparative efficacy cost executive function experience flexibility improved innovation instrument intervention effect mild cognitive impairment modifiable risk multimodality neural patterning novel pre-clinical processing speed psychosocial randomized trial relating to nervous system resilience

项目摘要

ABSTRACT Approximately 5.8 million adults age 60 and over in the United States live with Alzheimer disease and related dementias (AD/ADRD) at a cost of $290 billion per year. Older adults with mild cognitive impairment (MCI), an intermediate stage between typical aging and dementia, are 3-5 times more likely to progress to AD than those with normal cognition. Late-life engagement in cognitively challenging activities is associated with decreased risk of cognitive decline, and there is a need to address cognitive inactivity. Music interventions are a promising strategy to address late-life cognitive inactivity. Music training can change brain structure and function in non-musician adults, thereby leading to cognitive, perceptual, and psychosocial advantages. These changes in cognitive function are thought to occur because the multimodal, complex nature of music facilitates training-induced neural plasticity. However, the mechanisms are not yet understood, and most studies used traditional or rote keyboard training techniques. Music training based on improvisation principles—the spontaneous generation of musical melodies and rhythms—will likely have more potent effects on cognition and brain function. Improvisation facilitates cognitive flexibility, self-monitoring, novel idea generation, execution of unplanned motor sequences and entrance into a state of flow. Biologically, improvisation is associated with distinct neural patterns involving activation of prefrontal networks and other brain networks that are affected by aging. As a mechanism of behavior change, it is likely that improvisation training will uniquely improve self-regulation (the ability to monitor and control one's own behavior, emotions, or thoughts and modify to situational demands). Yet, no research has tested whether improvisation training can improve self- regulation and facilitate maintenance of cognitively challenging activities among older adults with and without MCI. This project will develop and test the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI. Our overall hypothesis is that improvisation training will lead to improvements in self-regulation, compared to controls, and that improvisation training will be associated with specific changes in prefrontal brain networks and ultimately cognitive engagement. Our project has two phases. In the R61 phase, we will develop a music improvisation training intervention that aims to improve self-regulation among older adults with and without MCI and conduct a 2-arm randomized pilot study to (i) examine feasibility and acceptability of the intervention and study methods and (ii) determine its effects on the hypothesized mechanism of self-regulation. If milestones are met, we will proceed to the R33 phase and conduct a randomized mechanistic trial to examine the effects of the intervention, compared to an attention control, on self-regulation and cognitive engagement among older adults with and without MCI. The findings from this study will improve our understanding of the underlying mechanisms of how music training interventions can facilitate behavior change to maintain health of older adults.

抽象的在美国，大约有580万60岁及60岁的成年人患有阿尔茨海默氏病及相关性痴呆症（AD/ADRD），每年为2900亿美元。患有轻度认知障碍的老年人（MCI），典型衰老和痴呆症之间的中级阶段，进行广告的可能性比那些的可能性高3-5倍具有正常认知。在认知上挑战活动的晚期参与与改善有关认知能力下降的风险，有必要解决认知不活跃。音乐干预是解决晚年认知不活动的有前途的策略。音乐训练可以改变大脑结构，在非音乐学家成年人中的功能，从而导致认知，感知和社会心理优势。这些由于音乐设施的多模式，复杂的性质，认知功能的变化被认为发生了训练引起的神经可塑性。但是，这些机制尚未理解，大多数研究都使用传统或腐烂的键盘培训技术。基于即兴原则的音乐培训 - 赞成的音乐旋律和节奏 - 可能会对认知有更大的潜在影响和大脑功能。即兴设施的认知灵活性，自我监控，新颖的想法产生，执行计划外的电机序列并进入流动状态。从生物学上讲，即兴创作与涉及前额叶网络和其他大脑网络激活的不同神经模式相关受衰老的影响。作为行为变化的机制，即兴培训可能会唯一改善自我调节（能够监视和控制自己的行为，情感或思想和思想的能力以及修改为情境需求）。但是，没有研究测试即兴培训是否可以改善自我监管和促进维持认知性挑战有或没有的老年人的活动 MCI。该项目将开发和测试音乐即兴训练的效果和机制有或没有MCI的老年人的自我调节的干预。我们的总体假设是即兴创作与对照组相比，培训将导致自我调节的改善，并且改进培训将与前额叶大脑网络的特定变化和最终认知参与有关。我们的项目有两个阶段。在R61阶段，我们将开发一项音乐即兴训练干预措施，旨在改善有或没有MCI的老年人的自我调节并进行2臂随机飞行员研究（i）研究和研究方法的可行性和可接受性，（ii）确定对假设的自我调节机制的影响。如果达到里程碑，我们将继续进行R33 相比有和没有MCI的老年人的注意力控制，对自我调节和认知参与。这这项研究的发现将提高我们对音乐训练方式的潜在机制的理解干预措施可以促进行为改变以维持老年人的健康。