Research Network to Accelerate Mechanistic Studies of Music for Dementia (RN-MusD)

加速音乐治疗痴呆症机制研究的研究网络 (RN-MusD)

• 批准号: 10764090
• 负责人: JULENE K JOHNSON
• 金额: $ 48.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764090
• 关键词: Acceleration; Adult; Affect; Agitation; Alzheimer' s Disease; Alzheimer' s disease related dementia; American; Anxiety; Arizona; Behavior; Behavioral; Brain; Brain imaging; California; Caregiver Burden; Caring; Catalogs; Code; Cognition; Collaborations; Complex; Dementia; Diagnosis; Educational workshop; Effectiveness; Elderly; Engineering; Ethnic Origin; Evaluation; FDA approved; Fostering; Frontotemporal Dementia; Funding; Geriatrics; Goals; Growth; Health; Hispanic-serving Institution; Imaging technology; Institution; Interdisciplinary Study; Intervention; Lewy Body Dementia; Measures; Mental Depression; Mentors; Methodology; Methods; Modeling; Moods; Morbidity - disease rate; Music; Music Therapy; Neurodegenerative Disorders; Outcome; Personal Satisfaction; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Pilot Projects; Prevalence; Publications; Quality of life; Randomized; Research; Research Personnel; Resources; Sampling; San Francisco; Science; Scientific Advances and Accomplishments; Symptoms; Technology; Testing; Time; Training; United States National Institutes of Health; Universities; Well in self; behavior change; brain research; cognitive neuroscience; cohort; cost; cost effective; disability; experience; health disparity; human old age (65+); improved; mobile computing; mortality; multidisciplinary; neural; neuroregulation; new technology; novel; prevent; programs; racial diversity; statistics; webinar; working group

ABSTRACT Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) represent the most common causes of dementia (cognition decline that leads to a loss of independent function) among adults. Approximately 1 in 9 Americans age 65 and over (11%) lives with dementia from AD, representing approximately 6.5 million people; prevalence rates increase when including related dementias. There are currently no treatments that prevent or halt the progression of dementia, although the 6 FDA-approved medications can help slow symptoms. Living with AD/ADRD is associated with loss of independence, disability, poor health and well-being (morbidity), and increased mortality. The care needs for people living with dementia (PLWD) are complex. Providing care is associated with high costs and considerable caregiver burden. There are also considerable health disparities for PLWD from diverse racial/ethnic backgrounds. Thus, there is an immediate need to identify novel, accessible, culturally relevant, and cost-effective approaches to reduce the burden and improve quality of life for older adults living with these common neurodegenerative diseases without a cure. We have known for over 35 years that people living with AD can meaningfully engage with music, even into the late stages. An increasing number of studies conclude that PLWD who participate in music therapy or music-based interventions (MBIs) experience improvements in quality of life, and emotional well-being as well as decreases in behavior issues, anxiety, and depression. Despite these promising findings, the number of studies is small, many are low quality, samples lack diversity, and the underlying mechanisms are not yet well understood. In addition, little is known about potential benefits of MBIs for people living with related dementias (ADRD). Studies using the NIH Stage Model and Science of Behavior Change methods can help improve study quality and provide a framework for developing and testing MBIs in the context of AD/ADRD. Moreover, use of novel mobile body-brain imaging (MoBI) technologies could help elucidate how MBIs affect various functions of the brain (including neuromodulation) and body in real-world settings. To accelerate rigorous research about the mechanisms by which MBIs impact health and well-being for adults with AD/ADRD, we will create the multi-disciplinary Research Network to Accelerate Mechanistic Studies of Music for Dementia (RN-MusD). The Network, representing experts from cognitive neuroscience, music therapy, biomedical and neural engineering, geriatrics, and statistics will create three core nodes at the University of California San Francisco, University of Houston, and Arizona State University. The Network will accelerate rigorous, multi-disciplinary, and mechanistic studies of MBIs in the context of AD/ADRD by accomplishing the following aims: (1) build a collaborative Network that will grow over time; (2) promote multidisciplinary collaborations through a pilot project program, leveraging MoBI and research mentoring, and (3) disseminate resources generated by our Network to sustain impact.

抽象的 阿尔茨海默氏病和阿尔茨海默氏病有关的痴呆症（AD/ADRD）是最常见的 成年人中痴呆症的原因（认知下降导致独立功能丧失）。 大约有9名美国人中有1名65岁及以上（11％）以AD的痴呆症生活，代表 大约有650万人；包括相关痴呆症的患病率会增加。有 目前尚无预防或阻止痴呆进展的治疗 药物可以帮助缓慢症状。与AD/ADRD一起生活与失去独立性，残疾， 健康和福祉（发病率）不良，死亡率增加。痴呆症患者的护理需求 （PLWD）很复杂。提供者护理与高昂的成本和相当大的照顾者负担有关。那里 对于来自潜水员种族/种族背景的PLWD的健康差异也很大。那有一个 立即需要确定新颖，可访问，具有文化相关和具有成本效益的方法，以减少 患有这些常见神经退行性疾病的老年人的负担和改善生活质量 无法治愈。我们已经知道35年以上的广告中的人们可以有意义地与之互动 音乐，甚至进入后期。越来越多的研究包括参加 音乐疗法或基于音乐的干预措施（MBIS）在生活质量和情感上都会改善 福祉以及行为问题，焦虑和抑郁症的下降。尽管有这些有希望的发现， 研究次数很少，许多质量低，样品缺乏多样性和潜在的机制 尚未很好地理解。此外，关于MBI的潜在利益对与之相处的人的潜在益处知之甚少 相关痴呆症（ADRD）。使用NIH阶段模型和行为改变方法的研究可以 有助于提高学习质量，并为开发和测试MBI提供一个框架 广告/adrd。此外，使用新颖的移动身体脑成像（MOBI）技术可以帮助阐明如何 MBI在现实世界中影响大脑的各种功能（包括神经调节）和身体。到 加速对MBI对成人影响健康和福祉的机制的严格研究 使用AD/ADRD，我们将创建多学科研究网络，以加速机械研究 痴呆症的音乐（RN-MUSD）。该网络代表来自认知神经科学，音乐的专家 疗法，生物医学和神经工程，老年医学和统计学将在 加利福尼亚大学旧金山，休斯敦大学和亚利桑那州立大学。网络将 在AD/ADRD的背景下，加速MBI的严格，多学科和机械研究 实现以下目的：（1）建立一个随着时间的推移而增长的协作网络； （2）促进 通过试点项目计划，利用MOBI和研究心理的多学科合作，以及 （3）传播我们网络生成的资源以维持影响。