Development Research Program

发展研究计划

• 批准号: 7893341
• 负责人: Eric R. Fearon
• 金额: $ 8.12万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7893341
• 关键词: Advertisements; Affect; Area; Budgets; Cancer Research Project; Clinical; Colorectal; Commit; Data; Development; Elements; Extramural Activities; Faculty; Fostering; Funding; Future; Generations; Goals; Grant; Human; Institution; Laboratories; Malignant neoplasm of gastrointestinal tract; Mentors; Mentorship; Michigan; NCI Center for Cancer Research; Pancreas; Patients; Pilot Projects; Protocols documentation; Reproduction spores; Research; Research Personnel; Research Project Grants; Research Proposals; Research Support; Risk; Scientist; Seasons; Staging; Translational Research; United States National Institutes of Health; Universities; University of Michigan Comprehensive Cancer Center; anticancer research; base; clinically relevant; expectation; high risk; improved; innovation; interest; meetings; population based; pre-clinical; programs; research and development; success; web site

Developmental Research Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As such, we will commit $140,000 annually to support three developmental research projects with budgets of approximately $45,000 each. The principal goal of the Developmental Research Program is to support innovative gastrointestinal cancer research with high translational impact, allowing investigators the ability to obtain key preliminary data for submission of an R01 application or an equivalent proposal (e.g., project in future SPORE application). Previously funded developmental research projects that have strong success during the initial funding period, but that have not obtained extramural funding, will be permitted to compete with new applications, with a maximum of two years of support possible. However, the expectation is that funds will support most projects for 1 year, with upwards of 15 new projects supported during the initial 5-year period of the grant. Projects will be solicited from University of Michigan Comprehensive Cancer Center (UMCCC) investigators and other University of Michigan faculty by campus-wide announcements and a standing advertisement for the Program at the UMCCC website listing other developmental research opportunities. Applications will utilize an NIH PHS398 format, with a 5-page limit on the body of the application (e.g., excluding references, detailed protocol information, appendix materials). Dr. Eric Fearon will serve as Director of the Developmental Research Program, and the UMCCC Cancer Research Committee (CRC) will undertake initial review, evaluating each proposal's scientific merit, innovation, gastrointestinal cancer relevance, and potential for translational impact. Given the CRC's expertise with rapid review of more than 100 pilot research proposals in laboratory, clinical, and population-based research annually, the CRC is well acquainted with review of projects with limited preliminary data. After review by the CRC, the Senior Advisory Group of the Gl SPORE will utilize assigned merit scores as a principal, but not sole, criterion in selection of proposals for support. Developmental research project investigators will take part in all Gl SPORE activities, and Dr. Fearon will meet quarterly with project Pis to offer in-depth review and mentorship.

发展研究 对发展研究项目的支持是 SPORE 的一个关键要素，对于培育开拓性举措至关重要。因此，我们每年将投入 140,000 美元来支持三个开发研究项目，每个项目的预算约为 45,000 美元。发展研究计划的主要目标是支持具有高转化影响的创新胃肠道癌症研究，使研究人员能够 能够获取提交 R01 申请或同等提案（例如未来 SPORE 申请中的项目）的关键初步数据。先前资助的开发研究项目在初始资助期间取得了巨大成功，但尚未获得外部资助，将被允许 与新应用程序竞争，最多可提供两年的支持。然而，预计资金将支持大多数项目 1 年，在赠款的最初 5 年期间将支持 15 个以上的新项目。项目将通过全校范围内的公告以及在 UMCCC 网站上列出该项目的常设广告来向密歇根大学综合癌症中心 (UMCCC) 研究人员和其他密歇根大学教员征集，其中列出了其他发展研究机会。申请将采用 NIH PHS398 格式，申请正文限制为 5 页（例如，不包括参考文献、详细方案信息、附录材料）。 Eric Fearon 博士将担任发展研究项目和 UMCCC 癌症研究主任 委员会 (CRC) 将进行初步审查，评估每项提案的科学价值、创新性、胃肠癌相关性以及转化影响的潜力。鉴于 CRC 每年快速审查 100 多项实验室、临床和人群研究试点研究提案的专业知识，CRC 非常熟悉对初步数据有限的项目的审查。经过 CRC 审查后，GL SPORE 高级顾问小组将利用分配的绩效分数作为选择支持提案的主要但不是唯一标准。发展研究项目调查员将参加所有 Gl SPORE 活动，Fearon 博士将每季度与 Pis 项目会面，提供深入的审查和指导。