Developmental Research Program

发展研究计划

• 批准号: 10554479
• 负责人: Eric R. Fearon
• 金额: $ 15.08万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-14 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10554479
• 关键词: Advertisements; Award; Basic Science; Biometry; Budgets; Cancer Center; Clinical; Collaborations; Communities; Data Reporting; Development; Early treatment; Elements; Ensure; Evaluation; Exclusion; Faculty; Feedback; Fostering; Funding; Future; Goals; Grant; Human; Institution; Laboratories; Locally Advanced Malignant Neoplasm; Mentors; Mentorship; Michigan; Molecular Target; Monitor; Outcome; Population Research; Process; Program Research Project Grants; Protocols documentation; Radiation therapy; Radiosensitization; Research; Research Personnel; Research Project Grants; Research Proposals; Resources; Schedule; Seasons; Treatment-Related Cancer; United States National Institutes of Health; Universities; Writing; anticancer research; career; data submission; expectation; high risk; innovation; member; novel; operation; peer; pre-clinical; programs; translational impact; translational potential; web site

PROJECT SUMMARY-ABSTRACT (DEVELOPMENTAL RESEARCH PROGRAM) Support for developmental research projects are a key SPORE element and are vital for fostering pioneering initiatives. As such, we will support 3 developmental research projects with budgets of approximately $50,000 each per year. The principal goal of the Developmental Research Program (DRP) is to support highly innovative radiation therapy related cancer research with high potential for translational impact, allowing investigators the ability to obtain key preliminary data for submission of an R01 application or an equivalent proposal (e.g. project in future SPORE application). A maximum of two years of support will be possible; however, the expectation is that funds will support most projects for one year, with 10-15 new projects supported during the five-year period of the grant. Projects will be solicited from University of Michigan Rogel Cancer Center investigators and other University of Michigan faculty by campus-wide announcements and a standing advertisement for the Program at the Cancer Center and institutional websites listing other developmental research opportunities. Applications will utilize an NIH format, with a 5-page limit on the body of the application (e.g. excluding references, detailed protocol information, appendix materials). Drs. Eric Fearon and Theodore Lawrence will serve as Co-Directors of the DRP. The Cancer Research Committee of the University of Michigan Rogel Cancer Center will undertake initial review, evaluating each proposal’s scientific merit, innovation, relevance to the theme of radiosensitization of locally advanced cancers and potential for translational impact. Given the Cancer Research Committee’s rapid and successful annual review of more than 100 pilot research proposals yearly in laboratory, clinical, and population-based research, the Committee is well-suited for the initial review process. After initial review, the SPORE’s Operations Committee will utilize assigned merit scores as a principal, but not sole, criterion in the selection of proposals for support. Developmental research project investigators will take part in all SPORE activities. Drs. Fearon or Lawrence will join mentoring committees set up for each project PI to offer in-depth review and mentorship.

项目摘要-摘要（开发研究计划） 对发展研究项目的支持是 SPORE 的一个关键要素，对于 因此，我们将支持 3 个发展研究项目。 每年大约 50,000 美元的预算 发展的主要目标。 研究计划 (DRP) 旨在支持与癌症相关的高度创新的放射治疗 具有很高转化影响潜力的研究，使研究人员能够 获取提交 R01 申请或同等文件的关键初步数据 提案（例如未来 SPORE 应用程序中的项目）最多可获得两年的支持。 可能；但是，预计资金将支持大多数项目一年， 五年资助期间将征集 10-15 个新项目。 来自密歇根大学罗格尔癌症中心研究人员和其他密歇根大学 教师通过全校范围的公告和该项目的常设广告 癌症中心和机构网站列出了其他发展研究机会。 申请将采用 NIH 格式，申请正文的页数限制为 5 页（例如 埃里克·费伦博士和 Theodore Lawrence 将担任 DRP 的联合主任。 密歇根大学罗格尔癌症中心委员会将进行初步审查， 评估每个提案的科学价值、创新性以及与主题的相关性 局部晚期癌症的放射增敏及其转化影响的潜力。 癌症研究委员会对 100 多个试点项目进行了快速、成功的年度审查 每年在实验室、临床和基于人群的研究中提出研究提案， 委员会非常适合初步审查过程。初步审查后，SPORE 的。 运营委员会将使用指定的绩效分数作为主要但不是唯一的标准 发展研究项目研究人员将参与选择支持提案。 Fearon 或 Lawrence 博士将加入为每个活动设立的指导委员会。 项目 PI 提供深入的审查和指导。