Multi-Disciplinary Training Program in Translational Cardiovascular Research

转化心血管研究的多学科培训计划

• 批准号: 10583494
• 负责人: William Gregory Hundley
• 金额: $ 39.66万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583494
• 关键词: Cardiovascular system; Research; Training Programs; multidisciplinary

This program is designed to train post-doctoral physicians and scientists capable of developing new advances in multi-disciplinary translational cardiovascular research directed toward the diagnosis, treatment and prevention of cardiovascular disease (CVD). Worldwide, CVD is the primary cause of morbidity and mortality for those >30 years in age; unfortunately in the US after years of decline, rates of CVD are now increasing in prevalence. This program will help to address the inadequate number of MD and PhD investigators (a shortage recognized by the NHLBI task force review of research training and career development programs) trained in multi-disciplinary CVD research activities that are needed to pursue solutions to reduce the burden of CVD. Our 5-year proposal includes the training of 4 MD applicants for 2 years beginning at the PGY 5 level, and 3 PhD applicants for 3 years beginning at the PGY 0 level. The program builds on research strengths at Virginia Commonwealth University (VCU) involving basic and clinical translational CV science using cellular, small animal, and single and multi-center population cohort and clinical trials. Key features of this proposed T32 training program include: 1) pairing each trainee with an externally funded research mentor whose research focuses on CVD; 2) outstanding multidisciplinary faculty who are experienced in training young investigators and can quickly establish this T32 program for fostering successful progress in academic medicine; 3) access to multiple phenotypic and biologic materials from major NIH-funded basic science, prospective cohort, or clinical trials at VCU through the supporting program faculty; 4) courses provided by the existing graduate school and medical faculty that supplement areas of CV research not previously experienced by trainees; and 5) two institutional seminar programs that enhances interaction among individuals from multiple disciplines. The proposed training program includes 15 faculty from 7 departments; these faculty currently mentor 11 individuals who meet the program eligibility criteria. Each has NIH or VA extramural funding; strong institutional support in the form of financial resources, facilities, and equipment; robust integration with the VCU Center of Health Disparities for recruiting and training minority scientists; and support for key professional development activities such as presentations and grant and manuscript writing. The ultimate goal of this T32 training program is to attract and train a cohort of outstanding academic scientists fluent in the latest developments of CV multidisciplinary translational research, who will then apply this knowledge to design and lead future studies regarding important questions in cardiovascular health. The proposed training program, with an emphasis on training both MD and PhD investigators, would augment the supply of physicians and scientists capable of developing new advances in multi- disciplinary translational cardiovascular research directed toward the treatment and prevention of cardiovascular disease, a major public health issue.

该计划旨在培训能够发展新进步的博士后医生和科学家 在多学科翻译心血管研究中，针对诊断，治疗和 预防心血管疾病（CVD）。全球CVD是发病率和死亡率的主要原因 对于30岁以上的年龄；不幸的是，在美国衰落多年后，CVD的比率正在上升 流行率。该计划将有助于解决数量不足的医学博士和博士调查人员（一个 NHLBI工作队认可的研究培训和职业发展计划的短缺） 经过多学科CVD研究活动的培训，需要寻求解决方案以减轻负担 CVD。我们的5年建议包括在PGY 5级开始对4个MD申请人进行培训， 从PGY 0级别开始3年和3个博士学位申请人。该计划以研究优势为基础 弗吉尼亚联邦大学（VCU）涉及基本和临床转化CV科学，使用细胞， 小动物，单一和多中心的人群队列和临床试验。此提议的关键特征 T32培训计划包括：1）将每个学员与外部资助的研究导师配对 研究重点是CVD； 2）在培训年轻方面经验丰富的杰出多学科教师 调查人员并可以迅速建立该T32计划，以促进学术的成功进步 药品; 3）从主要NIH资助的基础科学中获取多种表型和生物学材料， 通过支持计划教师在VCU进行的前瞻性队列或临床试验； 4）课程由 现有的研究生院和医学教师补充简历研究领域以前从未经历过 由学员； 5）两个机构研讨会计划，可以增强个人之间的互动 多个学科。拟议的培训计划包括来自7个部门的15名教职员工；这些教师 目前，符合该计划资格标准的11个人。每个人都有NIH或VA外部 资金;以财务资源，设施和设备形式的强大机构支持；强壮的 与VCU健康差异中心融合，以招募和培训少数族裔科学家；和支持 用于关键的专业发展活动，例如演讲，赠款和手稿写作。这 该T32培训计划的最终目标是吸引和培训一批杰出的学术科学家 精通简历多学科翻译研究的最新发展，然后将其应用 设计和领导有关心血管健康重要问题的未来研究的知识。这 拟议的培训计划，重点是培训MD和博士调查人员，将 增加能够发展多种新进展的医师和科学家的供应 纪律转化心血管研究针对治疗和预防 心血管疾病，这是一个主要的公共卫生问题。