Core D-Neuropathology Core

核心 D-神经病理学核心

• 批准号: 10582632
• 负责人: EDWIN S MONUKI
• 金额: $ 47.31万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582632
• 关键词: Adherence; Age; Aliquot; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Amyloid beta-Protein; Artificial Intelligence; Astrocytes; Autopsy; Award; Biological Markers; Biology; Blood specimen; Brain; California; Catalogs; Cd68; Cells; Clinical; Clinical Data; Collaborations; Collection; Data Set; Deposition; Diagnosis; Diagnostic; Disease; Doctor of Philosophy; Down Syndrome; Education; Ensure; Equipment and supply inventories; Faculty; Family; Fibroblasts; Functional disorder; Funding; Generations; Genetic Diseases; Glial Fibrillary Acidic Protein; Goals; Grant; Guidelines; Harvest; Head; Health system; Hour; Individual; Infrastructure; Institution; International; Light; Link; Longevity; Magnetic Resonance Imaging; Mentorship; Methods; Microglia; Microscopy; Minority; Morphology; National Institute on Alcohol Abuse and Alcoholism; Neurons; Participant; Pathology; Performance; Practice Guidelines; Predisposition; Process; Protocols documentation; Publications; Reporting; Research; Research Personnel; Resources; Rotation; Sampling; Services; Site; Skin; Special Population; Stains; Standardization; System; Training and Education; Universities; Visit; Work; adjudication; biobank; brain tissue; cell type; clinical conference; clinical trial participant; cohort; data management; digital; education research; genome wide association study; glial activation; high risk; induced pluripotent stem cell; innovation; integration site; member; mixed dementia; neuropathology; next generation; novel; operation; outreach; professor; recruit; tau Proteins; whole slide imaging

PROJECT SUMMARY – NEUROPATHOLOGY CORE (CORE D) The UCI ADRC Neuropathology (NP) Core provides autopsy, diagnostic, and biorepository services for the three cohorts of the UCI ADRC - Uniform Data Set (UDS), 90+, and Down syndrome - which span a broad range of ages and susceptibilities to AD. The overarching goal of the NP Core is to support education, outreach, and research on AD and related disorders (ADRD) in collaboration with other ADRC cores and ADRD researchers to “identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Since its inception, the NP Core has collected and maintained a considerable bank of high-quality biospecimens, which have been distributed broadly to NCRAD and federally-funded local, national, and international ADRD investigators and consortia. Core operations have been continually enhanced, and metrics of core performance are strong. To expand its capacity, three new faculty have joined the NP Core, including a neuropathologist who is also a REC mentee (Mari Perez-Rosendahl). Together with the other UCI ADRC Cores, the NP Core proposes six Aims to enhance its diagnostic, education, and research functions via collaboration, innovation, and education: 1) Provide accurate, timely, comprehensive, and standardized postmortem examinations and diagnostic reports on UDS subjects and special populations, including the addition of postmortem skin collection on selected cases in collaboration with the iPSC Core; 2) Harvest, process, store, catalog, and distribute high-quality brain tissue and biospecimens to ADRD researchers at UCI and beyond, collaborating with the DMS and Biomarker Cores in its data management and biospecimen utilization functions; 3) Incorporate new analysis methods to enable novel microglial studies by UCI investigators at the cutting-edge of a new microglial biology in AD; 4) Incorporate whole slide imaging (WSI) to facilitate diagnoses, research, and education, including the establishment of interfaces with a UC-wide WSI network and UCI artificial intelligence (AI) center; 5) Support novel ADRD research and outreach in collaboration with other UCI ADRC Cores and other ADRCs, including new studies involving postmortem MRI, light sheet microscopy of cleared brain tissues, and AI studies of WSIs; and 6) Contribute unique expertise to the education and training of the next generation of AD clinicians and researchers, including Dr. Perez- Rosendahl, neuropathologist and REC mentee.

项目摘要 - 神经病理学核心（核心D） UCI ADRC神经病理学（NP）核心为尸检，诊断和生物验证服务提供 UCI ADRC-统一数据集（UDS），90+和唐氏综合症的三个队列 - 广告的年龄和敏感性范围。 NP核心的总体目标是支持教育， 与其他ADRC核心合作的广告和相关疾病（ADRD）的研究和研究 ADRD研究人员“识别，量化和验证影响整个寿命的AD风险的因素”。 自成立以来，NP核心已收集并维护了相当大的高质量库 生物测量已广泛分配给NCRAD和联邦政府资助的地方，国家和 国际adrd调查人员和具体。核心操作不断增强，指标 核心性能很强。为了扩大其能力，三个新教师加入了NP核心，包括 神经病理学家也是REC指导者（Mari Perez-Rosendahl）。与其他UCI ADRC一起 核心，NP核心提案六个旨在通过 协作，创新和教育：1）提供准确，及时，全面和标准化 验尸检查和有关UDS受试者和特殊人群的诊断报告，包括 与IPSC核心合作，在选定病例上添加了验尸皮肤收集； 2）收获， 在UCI的ADRD研究人员的过程，存储，目录和分配高质量的脑组织和生物测量 除了之外，还与DMS和生物标志物核心合作在其数据管理和生物测试中 利用功能； 3）结合了新的分析方法，以实现UCI的新小胶质细胞研究 AD新小胶质生物学的前沿研究人员； 4）将整个幻灯片成像（WSI）合并到 促进诊断，研究和教育，包括建立具有UC范围WSI的界面 网络和UCI人工智能（AI）中心； 5）支持新颖的ADRD研究和外展 与其他UCI ADRC核心和其他ADRC合作，包括涉及验尸MRI的新研究， 清除的脑组织的轻度显微镜和WSIS的AI研究； 6）为独特的专业知识 下一代广告临床医生和研究人员的教育和培训，包括佩雷斯博士 Rosendahl，神经病理学家兼REC导师。