THE ROLE OF LHX2 IN MEDIATING CELLULAR ADHESIVE PROPERTIES

LHX2 在调节细胞粘附特性中的作用

• 批准号: 7724071
• 负责人: EDWIN S MONUKI
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724071
• 关键词: Adhesives; Biological Assay; Cell Adhesion; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Image; Institution; Mediating; Microscopy; Photons; Property; Research; Research Personnel; Resources; Role; Series; Source; United States National Institutes of Health; mutant; reconstruction; transcription factor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We examine the transcription factor, Lhx2, and how loss of Lhx2 function effects cell adhesion. Short-term aggregation assays are performed between Lhx2 null mutant and littermate controls. The aggregates are imaged in the LFD by two-channel, 2-photon microscopy in a Z-series. 3D reconstructions of the aggregates will be generated from the Z-series images.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们检查了转录因子LHX2，以及LHX2功能的丧失如何影响细胞粘附。 在LHX2 NULL突变体和同立物材料对照组之间进行短期聚合测定。 聚集体是通过Z系列中的两通道2光子显微镜在LFD中成像的。 聚集体的3D重建将从Z系列图像中生成。