Core D-Neuropathology Core

核心 D-神经病理学核心

基本信息

批准号：
9922103
负责人：
EDWIN S MONUKI
金额：
$ 43.15万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9922103
关键词：
Adherence Age Aliquot Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease risk Amyloid beta-Protein Artificial Intelligence Astrocytes Autopsy Award Biological Markers Biology Blood specimen Brain California Catalogs Cells Clinical Clinical Data Collaborations Collection Data Set Deposition Diagnosis Diagnostic Diagnostics Research Disease Doctor of Philosophy Down Syndrome Education Education and Outreach Ensure Equipment and supply inventories Faculty Family Fibroblasts Functional disorder Funding Generations Genetic Diseases Glial Fibrillary Acidic Protein Goals Gold Grant Guidelines Harvest Head Health system Hour Individual Infrastructure Institution International Light Link Longevity Magnetic Resonance Imaging Mentorship Methods Microglia Microscopy Minority Morphology Neurons Outreach Research Participant Pathology Performance Practice Guidelines Predisposition Process Protocols documentation Publications Reporting Research Research Personnel Resources Rotation Sampling Services Site Skin Stains Standardization Structure System Time Training and Education Universities Visit Work adjudication biobank brain tissue cell type clinical trial participant cohort data management diagnosis standard digital education research genome wide association study high risk induced pluripotent stem cell innovation integration site member mixed dementia named group neuropathology next generation novel operation outreach professor recruit symposium tau Proteins whole slide imaging

项目摘要

PROJECT SUMMARY – NEUROPATHOLOGY CORE (CORE D) The UCI ADRC Neuropathology (NP) Core provides autopsy, diagnostic, and biorepository services for the three cohorts of the UCI ADRC - Uniform Data Set (UDS), 90+, and Down syndrome - which span a broad range of ages and susceptibilities to AD. The overarching goal of the NP Core is to support education, outreach, and research on AD and related disorders (ADRD) in collaboration with other ADRC cores and ADRD researchers to “identify, quantify, and validate factors that influence the risk of AD across the lifespan.” Since its inception, the NP Core has collected and maintained a considerable bank of high-quality biospecimens, which have been distributed broadly to NCRAD and federally-funded local, national, and international ADRD investigators and consortia. Core operations have been continually enhanced, and metrics of core performance are strong. To expand its capacity, three new faculty have joined the NP Core, including a neuropathologist who is also a REC mentee (Mari Perez-Rosendahl). Together with the other UCI ADRC Cores, the NP Core proposes six Aims to enhance its diagnostic, education, and research functions via collaboration, innovation, and education: 1) Provide accurate, timely, comprehensive, and standardized postmortem examinations and diagnostic reports on UDS subjects and special populations, including the addition of postmortem skin collection on selected cases in collaboration with the iPSC Core; 2) Harvest, process, store, catalog, and distribute high-quality brain tissue and biospecimens to ADRD researchers at UCI and beyond, collaborating with the DMS and Biomarker Cores in its data management and biospecimen utilization functions; 3) Incorporate new analysis methods to enable novel microglial studies by UCI investigators at the cutting-edge of a new microglial biology in AD; 4) Incorporate whole slide imaging (WSI) to facilitate diagnoses, research, and education, including the establishment of interfaces with a UC-wide WSI network and UCI artificial intelligence (AI) center; 5) Support novel ADRD research and outreach in collaboration with other UCI ADRC Cores and other ADRCs, including new studies involving postmortem MRI, light sheet microscopy of cleared brain tissues, and AI studies of WSIs; and 6) Contribute unique expertise to the education and training of the next generation of AD clinicians and researchers, including Dr. Perez- Rosendahl, neuropathologist and REC mentee.

项目摘要 – 神经病理学核心（核心 D） UCI ADRC 神经病理学 (NP) 核心为以下人群提供尸检、诊断和生物样本库服务： UCI ADRC 的三个队列 - 统一数据集 (UDS)、90+ 和唐氏综合症 - 涵盖广泛 NP 核心的总体目标是支持教育、与其他 ADRC 核心合作，开展 AD 及相关疾病 (ADRD) 的推广和研究 ADRD 研究人员“识别、量化和验证影响整个生命周期 AD 风险的因素”。自成立以来，NP Core 收集并维护了大量的高质量生物样本，已广泛分发给 NCRAD 和联邦政府资助的地方、国家和地区国际 ADRD 调查员和财团的核心业务不断得到加强，指标也不断得到加强。为了扩大其能力，三名新教师加入了 NP 核心，其中包括一名。神经病理学家，也是 REC 学员 (Mari Perez-Rosendahl) 与另一位 UCI ADRC 一起。 Cores，NP 核心提出了六个目标，以通过以下方式增强其诊断、教育和研究功能：协作、创新、教育：1）提供准确、及时、全面、规范的 UDS受试者和特殊人群的尸检和诊断报告，包括与 iPSC 核心合作，增加对选定病例的死后皮肤采集；2) 收获；处理、存储、编目并向 UCI 的 ADRD 研究人员分发高质量的脑组织和生物样本以及其他方面，与 DMS 和 Biomarker Cores 在数据管理和生物样本方面进行合作 3) 结合新的分析方法以实现 UCI 的新型小胶质细胞研究 AD 中新小胶质细胞生物学前沿的研究人员 4) 将全玻片成像 (WSI) 纳入促进诊断、研究和教育，包括与加州大学范围内的 WSI 建立接口网络和 UCI 人工智能 (AI) 中心；5) 支持新型 ADRD 研究和推广与其他 UCI ADRC 核心和其他 ADRC 合作，包括涉及死后 MRI 的新研究，透明脑组织的光片显微镜检查和 WSI 的人工智能研究；6) 贡献独特的专业知识；下一代AD信徒和研究人员的教育和培训，包括佩雷斯博士- Rosendahl，神经病理学家和 REC 学员。