The Effectiveness and Cost-Effectiveness of Implementing Evidence-Based Depression Treatment within the TB Care Platform in South Africa: A Hybrid Effectiveness-Implementation Trial

在南非结核病护理平台内实施循证抑郁症治疗的有效性和成本效益：一项混合有效性与实施试验

• 批准号: 10582160
• 负责人: Annika Claire Sweetland
• 金额: $ 7.19万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582160
• 关键词: Address; Caliber; Caring; Data; Data Collection; Effectiveness; Funding; Goals; Grant; Manuscripts; Mental Depression; Mentored Research Scientist Development Award; Mentors; Methodology; Methods; Paper; Parents; Patients; Preparation; Prevalence; Primary Care; Research; Research Activity; Research Methodology; Research Personnel; Research Support; Resource-limited setting; Science; Scientist; Site; South Africa; Structure; Training; Writing; career; career development; contextual factors; cost effectiveness; dissemination science; effectiveness/implementation trial; evidence base; experience; hands on research; hazardous drinking; implementation science; skills; social

PROJECT SUMMARY We propose a Diversity Supplement for Dr. Ernesha Webb Mazinyo to provide her the appropriate setting, training, individualized mentoring and research experience necessary to launch her career as an independently- funded implementation scientist. In order to achieve this goal, Dr. Webb Mazinyo will receive mentoring and research support, didactic coursework in dissemination and implementation science (D&I), hands-on research experience including primary data collection and mixed-methods analysis, and assistance with grant writing and manuscript preparation. Dr. Webb Mazinyo will be mentored by Drs. Annika Sweetland (PI), Andrew Medina- Marino (site-PI, Co-I) and Milton Wainberg (Co-I), to advise her as she pursues D&I research focused on integrating TB, depression and hazardous drinking (HD) treatment within primary care. Drs. Sweetland, Medina- Marino, and Wainberg have relevant methodological expertise in D&I science and mixed-methods research; topical expertise on the intersection of TB, depression and HD; and a successful track-record mentoring early investigators. This application builds upon the parent-study by expanding the scientific scope to include HD among TB patients with and without depression. Dr. Webb Mazinyo will participate in all research activities related to the parent study, including the preparation and submission of scientific papers/proposals, along with didactic and career development activities. Dr. Webb Mazinyo’s hands-on research will include two research aims: AIM 1: To leverage parent study data to estimate the prevalence and social correlates of HD among TB patients with and without depression. AIM 2: To investigate contextual factors and potential barriers/facilitators to integrating treatment for depression and HD within the TB care platform. Taken together, the research activities proposed for this Diversity Supplement will develop Dr. Webb Mazinyo’s D&I research skills and will provide the structure and support needed for her to become a highly successful independent researcher able to address integration of treatment for HD for patients with TB in South Africa and other low-resource settings. Our main objective is to support Dr. Webb Mazinyo to apply for and obtain a K01 award to support her goal of becoming a researcher of the highest caliber in the field of D&I.

项目摘要 我们建议对Ernesha Webb Mazingo博士提供多样性，以便为她提供适当的环境， 培训，个性化的指导和研究经验才能启动她的护理护理护理护理护理护理护理 为了实现这一目标，资助的实施科学家将获得指导 研究支持，传播和实施的教学课程（D＆I），动手研究 包括主要数据收集和混合方法分析的经验，以及在赠款写作方面的协助和 手稿准备。 Marino（Site-Pi，Co-I）和Milton Wainberg（Co-I），建议她从事D＆I研究的重点 将TB，抑郁症和危险性饮酒（HD）纳入初级保健。 Marino和Wainberg在D＆I科学与方法研究方面具有Relevelevant Methodocal专业知识； TB，抑郁和高清交集的局部专业知识 调查人员。 在患有和抑郁症的结核病患者中。 与父母研究，科学论文/建议的准备和提交有关 教学和职业发展活动。 目标： 目的1：利用父母研究数据来估计结核病之间高清的患病率和社会相关性 有和没有抑郁症的患者。 目标2：调查上下文因素和潜在的障碍/促进者，以整合治疗 结核病护理平台内的深度和高清。 综上所述，为多样性供应提供的研究活动将发展Webbbb Mazingo博士 D＆I研究技能，将为她提供非常成功所需的结构和支持 独立研究人员能够解决南非南非与结核病专业的HD治疗集成以及 我们的主要背景是我们的主要目标。 奖项是为了支持她成为D＆I领域最高能力的培训者的目标。