Water Intake and Weight Control in Older Adults

老年人的饮水量和体重控制

• 批准号: 10582833
• 负责人: BRENDA M DAVY
• 金额: $ 69.18万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10582833
• 关键词: Acute; Address; Adherence; Adult; American; Appetite Regulation; Area; Attention; Behavior; Behavioral Mechanisms; Body Weight decreased; Clinical; Clinical Practice Guideline; Cognition; Cognitive; Consumption; Control Groups; Dehydration; Desire for food; Diet; Disease; Elderly; Energy Intake; Esthesia; Evaluation; Face; Goals; Health Benefit; High Prevalence; Hormones; Hunger; Hydration status; Impaired cognition; Impairment; Instruction; Insulin; Intervention; Intervention Trial; Kidney Calculi; Link; Maintenance; Measures; Mediating; Mediator; Medical; Nutritional Study; Obesity; Osmolalities; Outcome; Overweight; Participant; Performance; Phase; Population; Randomized, Controlled Trials; Recommendation; Research; Satiation; Serum; Stomach; Strategic Planning; Time; United States National Institutes of Health; Urinary tract infection; Urine; Water; Water consumption; Weight; Weight Gain; Weight maintenance regimen; Woman; adult obesity; aged; attentional control; cognitive function; comparison control; cost; dietary; dietary adherence; dietary guidelines; disability risk; drinking water; efficacy study; evidence base; evidence based guidelines; executive function; fasting glucose; healthy lifestyle; improved; lifestyle intervention; men; middle age; obesity risk; obesity treatment; overweight adults; prevent; randomized controlled design; success; treatment as usual; trial design; usual care arm; weight maintenance; working group

Project Summary/Abstract The lack of practical and effective strategies to manage hunger and adhere to a weight management intervention represents a critical barrier to the weight management field. In proof-of-concept efficacy studies, we have demonstrated that premeal water consumption (500 ml) acutely reduced perceived hunger and meal energy intake among middle-aged and older adults, and that premeal water consumption (500 ml, 3 times per day) increased the amount of weight lost (i.e., 2 kg greater loss) after 12 weeks among middle-aged and older adults with overweight or obesity. However, water consumption may be important for weight management regardless of when it is consumed. To address this possibility, we propose a rigorously-designed randomized controlled intervention trial in adults aged 50+ years with overweight or obesity comparing three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, urine volume, and serum osmolality will be used as objective indicators of compliance with the water intake prescription. We will investigate changes in perceived hunger and fullness and appetite-regulating hormones as potential mechanisms by which premeal water could improve appetite regulation. We will also investigate the impact of water consumption and hydration on executive function capabilities, which may influence intervention adherence. We hypothesize that weight loss at 12 weeks, and weight loss maintenance at 12 months, will be greater in the premeal water group compared to the daily water volume and control groups. Furthermore, when combined with a hypocaloric diet, premeal water will reduce hunger and increase fullness; these changes will mediate adherence to the hypocaloric diet and weight loss outcomes. Although increasing water intake could be an effective weight management strategy, no evidence-based recommendations exist for the timing of water intake needed for this benefit. Our findings could identify a low-cost, actionable dietary strategy that could be incorporated into clinical practice guidelines for obesity treatment, and improve adherence to a hypocaloric diet prescription through reduced hunger, increased fullness, and improved attention and inhibitory control. This proposal is aligned with the 2020-2030 NIH Strategic Plan for Nutrition Research (Objective 3.5) and the Dietary Guidelines for Americans 2020-2025 due to its focus on older adults, an understudied population at increased risk for obesity and inadequate hydration. If effective, this hydration/weight control intervention approach could be applied to clinical populations such as adults with obesity who are prescribed increased water intake to prevent or treat kidney stone disease or urinary tract infections, which are common in older adults.

项目摘要/摘要 缺乏实用有效的策略来管理饥饿并遵守体重管理干预措施 代表体重管理领域的关键障碍。在概念验证疗效研究中，我们有 证明了预先耗水（500毫升）急性减少感知的饥饿和饮食能量 中年和老年人的摄入量，以及预先耗水的摄入量（每天500毫升，3次） 在中年和老年人中，增加了12周后增加体重的体重（即损失2公斤） 超重或肥胖。但是，无论如何，用水对于体重管理可能很重要 消耗何时。为了解决这种可能性，我们提出了一个严格设计的随机控制 比较三组不同饮食的50岁以上成年人的干预试验 处方：1）使用低温饮食的粉刷前用水（每餐前500毫升）； 2）1500 ML全天用低温饮食消耗的水； 3）无关紧要的饮食没有任何指示 用水。智能水瓶将客观地评估摄入时间和体积。尿液渗透压， 尿量和血清渗透压将用作遵守水摄入量的客观指标 处方。我们将调查感知到的饥饿，饱满和食欲调节的激素的变化 预先水可以改善食欲调节的潜在机制。我们还将调查 用水和水合对执行功能能力的影响，这可能会影响干预 坚持。我们假设12周时的体重减轻，而在12个月时的减肥维持将是 与每日的水量和对照组相比，预先水域的水组更大。此外，什么时候 结合无关紧要的饮食，预尔水会减少饥饿并增加饱满度。这些变化将会 介导遵守低温饮食和减肥结果。虽然摄入量增加可能是 一种有效的体重管理策略，没有关于水时机的循证建议 这项收益所需的进气。我们的发现可以确定一种低成本，可操作的饮食策略 纳入肥胖治疗的临床实践指南，并提高依从性低温饮食 通过减少饥饿，增加饱满度以及提高注意力和抑制性控制的处方。这 提案与2020-2030 NIH营养研究战略计划（目标3.5）和饮食一致 2020 - 2025年美国人的指南由于其专注于老年人，因此人口研究的人口有所增加 肥胖和水合不足的风险。如果有效，这种补水/体重控制干预方法可以 适用于临床人群，例如处方肥胖的成年人，他们的摄入量增加了 预防或治疗在老年人中常见的肾脏结石或尿路感染。