PREVENTION OF ORAL CANCER BY TEA

通过茶预防口腔癌

• 批准号: 7719058
• 负责人: FUNG-LUNG CHUNG
• 金额: $ 57.69万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719058
• 关键词: Biological; Black Tea; Blood; Cells; Class; Clinic Visits; Computer Retrieval of Information on Scientific Projects Database; Control Groups; DNA Damage; Fatty Liver; Funding; Goals; Grant; Green tea; Incidence; Institution; Light; Malignant neoplasm of liver; Obesity; Oral; Participant; Placebos; Polyunsaturated Fatty Acids; Research; Research Personnel; Resources; Risk Factors; Role; Running; Sampling; Smoker; Source; Tea; United States National Institutes of Health; Urine; Water; Week; adduct; drinking; healthy volunteer; non-smoker; oral cancer prevention; oxidation; research clinical testing; treatment duration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is for healthy volunteers. Participants will be divided into two groups: current smokers and a control group of non-smokers. In both groups, green tea and black tea, caffeinated water and water (placebo) will be drunk for 4 weeks each treatment with an initial 3-week run-in and 2-week "washout" period. During these treatment periods, oral cells will be collected weekly, urine samples weekly, and blood will be collected bi-weekly. Clinical evaluation of participants will be performed initially, then monthly. Participants will be required to visit the clinic once each week. The study will last, including treatments, 25 weeks. Our goal is to investigate the specific biological roles of one class of DNA damage formed by oxidation of polyunsaturated fatty acids called cyclic adducts in causing liver cancer. Incidences of liver cancer are on the rise in the U.S., and evidence indicates that obesity and fatty livers are potential risk factors. Therefore, our long-term goal is to generate information in order to shed light on possible mechanisms of obesity in liver cancer.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究是针对健康志愿者的。参与者将被分为两组：当前吸烟者和非吸烟者对照组。两组患者每次治疗都会饮用绿茶和红茶、含咖啡因的水和水（安慰剂）4 周，并有 3 周的初始磨合期和 2 周的“冲洗”期。在这些治疗期间，将每周采集口腔细胞，每周采集尿液样本，每两周采集一次血液。参与者的临床评估将首先进行，然后每月进行一次。参与者需要每周去诊所一次。该研究（包括治疗）将持续 25 周。 我们的目标是研究由称为环状加合物的多不饱和脂肪酸氧化形成的一类 DNA 损伤在导致肝癌中的具体生物学作用。在美国，肝癌的发病率正在上升，有证据表明肥胖和脂肪肝是潜在的危险因素。因此，我们的长期目标是生成信息，以阐明肥胖与肝癌的可能机制。