Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults

一生中噪声暴露对老年人平衡和稳定性的影响

基本信息

批准号：
10833752
负责人：
Natela M. Shanidze
金额：
$ 3.59万
依托单位：
VETERANS EDUCATION AND RESEARCH ASSOCIATION OF MICHIGAN
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10833752
关键词：
Acceleration Accidents Acoustics Address Affect Age Aging Anatomy Animal Experimentation Animal Model Animals Basic Science Cells Cervical Cessation of life Characteristics Clinical Cochlea Compensation Control Groups Detection Devices Diagnosis Disease Dose Elderly Electrophysiology (science)Environment Epithelium Equilibrium Exhibits Exposure to FDA approved Force of Gravity Frequencies Functional disorder Genetic Goals Head Head Movements Hearing Human Impairment Individual Injury Investigation Judgment Labyrinth Life Link Longevity Maintenance Measurement Measures Methods Modeling Morphology Motion Motor Musculoskeletal Equilibrium Neurons Noise Noise-Induced Hearing Loss Organ Outcome Participant Performance Physical shape Physiological Play Population Posture Predisposition Prevention Proprioception Rattus Recommendation Recording of previous events Reflex action Rehabilitation therapy Risk Risk Factors Role Rotation Secondary to Semicircular canal structure Sensory Source Spinal Cord Structure Symptoms System Testing Time Training Variant Vestibular Nerve Vestibular loss Vision Walking age group age related aging population body position clinical application cohort comparison control cost disability equipment acquisition experimental study fall risk falls functional improvement human old age (65+)human subject improved insight motor impairment neglect noise exposure otoconia parent grant posture instability pressure response secondary analysis senescence sound treatment strategy vestibulo-ocular reflex

项目摘要

Abstract Loss of stability and falls is a major risk factor for injury and death in older adults. Previously overlooked, lifetime noise exposure has been shown to cause damage to the vestibular periphery; although, animal models and human studies that can provide a mechanistic basis connecting noise-induced vestibular dysfunction and age-related fall risk are limited. The vestibular system plays a critical role in detection of head movements and orientation with respect to gravity and is essential for normal vision and postural control. Due to their anatomical proximity to the cochlea, the otolith organs are exposed to sound pressure and are at risk for noise overstimulation, which may contribute to vestibular dysfunction. Recent studies have linked noise overstimulation to decreased vestibular nerve activity and loss of a specialized class of irregularly firing vestibular afferents which exhibit enhanced sensitivity to acceleration. It is likely that these afferents play an important role initiating postural compensation for abrupt changes in head or body position due to their physiological characteristics and their projection to secondary vestibular neurons that project to the spinal cord. Therefore, the effects of noise may accelerate disability associated with natural aging. The goal of this supplement is to purchase equipment to measure vestibular evoked myogenic potentials (VEMP) in human participants, and thus assess changes in otolith function associated with noise exposure. The inclusion of VEMP reflects Reviewer recommendation to use vestibular-evoked myogenic potentials to directly assess how noise exposure might affect otolith function in humans and compare to outcomes in the rat. The VEMP experiments will be performed in lieu of the dynamic tilt detection experiments proposed in the parent grant. VEMP testing can be done in the same, or shorter amount of time to assess otolith function under dynamic stimulation conditions. This supplement will allow us to incorporate a well-characterized physiological assessment in human subjects to evaluate the underlying mechanisms in increased falls and fall risk due to a history of noise exposure in older adults. The susceptibility of these individuals to potentially fatal falls underscores the need for a systematic approach, that can eventually result in improved training and rehabilitation methods to be used with this population.

抽象的稳定和跌倒的丧失是老年人受伤和死亡的主要危险因素。以前被忽视，终生噪声暴露已显示会对前庭外围造成损害。虽然，动物模型以及可以提供机械基础的人类研究，以连接噪声引起的前庭功能障碍和与年龄有关的秋季风险有限。前庭系统在检测头部运动和关于重力的方向，对于正常视力和姿势控制至关重要。由于他们与耳蜗的解剖学接近，耳石器官暴露于声音压力，有噪音的风险过度刺激，可能导致前庭功能障碍。最近的研究与噪音联系在一起过度刺激到降低前庭神经活性和专业类不规则射击的丧失前庭传入，表现出对加速度的敏感性增强。这些传入可能会发挥重要的角色引发了由于其头部或身体位置突然变化而引起的姿势补偿生理特征及其对脊髓投射的次生前庭神经元的投影。因此，噪声的影响可能会加速与自然衰老有关的残疾。目标的目标补充是购买设备以测量人类的前庭诱发肌遗传电位（VEMP）参与者，因此评估与噪声暴露相关的耳石功能的变化。包括 VEMP反映了审稿人建议使用前庭诱发的肌源性潜能直接评估如何噪声暴露可能会影响人类的耳石功能，并与大鼠的结果相比。 vemp 实验将代替父母赠款中提出的动态倾斜检测实验。 VEMP测试可以以相同的方式进行，也可以在动态下评估耳石功能的时间较短刺激条件。这种补充剂将使我们能够合并一个特征良好的生理学评估人类受试者的评估，以评估跌倒和跌倒风险增加的潜在机制老年人的噪音暴露历史。这些人对潜在致命跌倒的敏感性强调了对系统方法的需求，最终可以改善培训和与该人群一起使用的康复方法。