Coherence-Based Fetal Ultrasonic Imaging

基于相干性的胎儿超声成像

基本信息

批准号：
10570866
负责人：
Gregg E. Trahey
金额：
$ 49.47万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10570866
关键词：
Abdomen Affect Aneuploidy Anxiety Blinded Cardiac Cesarean section Clinical Research Clutterings Congenital diaphragmatic hernia Counseling Data Detection Developed Countries Diagnosis Diagnostic Diffuse Discipline of obstetrics Environment Failure Fetal Development Fetal Growth Fetal Monitoring Fetal Structures Fetal Viability Fetal health Fetus First Pregnancy Trimester Frequencies Gestational Age Human Image Image Analysis Imaging Techniques Life Location Maps Maternal Health Measures Methods Morbidity - disease rate Mothers Multiple Pregnancy Noise Obesity Operative Surgical Procedures Ovary Overweight Pathology Patient imaging Patients Pelvis Placenta Pregnancy Property Publishing Research Resolution Role Scanning Second Pregnancy Trimester Source Structure Sum Techniques Translations Ultrasonics Ultrasonography United States Uterus Visualization Woman comparative cost fetal follow-up imaging modality improved in vivo maternal outcome mortality neonate novel postnatal public health relevance quantitative imaging simulation tertiary care theories ultrasound unnecessary treatment

项目摘要

Abstract Ultrasonic imaging is widely used to monitor fetal growth and development during the first and second trimester, and multiple studies document the resultant positive impacts on fetal and maternal outcomes. However, current methods fail to provide adequate visualization of key structures in many patients, and alternative imaging modes are rarely available to these patients. We have developed novel ultrasonic beamforming methods that utilize the spatial coherence of backscattered echoes. These methods, in simulation, phantom, and blinded-observer clinical studies, show markedly improved image quality over conventional ultrasonic images, especially in difficult-to-image patients. We propose extend our theory of coherence imaging to 1.5D and 2D arrays and to very large arrays. Using such advanced arrays, we propose clinical studies to assess the role of coherence imaging in key fetal diagnostic tasks in first trimester and second trimester scans. Quantitative image quality metrics and observer studies are proposed to compare B-mode and coherence images with an emphasis on difficult-to-image patients for whom current imaging methods fail. Related studies will measure the contribution of various sources of image degradation in fetal scans. If successful, the proposed research could lead to a new class of ultrasonic beamforming methods that operate in imaging environments in which current methods fail.

抽象的超声成像被广泛用于监测第一和第二孕期和多项研究记录了对胎儿和母体的积极影响结果。但是，当前的方法无法在许多人中提供足够的关键结构的可视化这些患者很少使用患者和替代成像模式。我们已经发展了利用反向散射回声的空间相干性的新型超声波束形成方法。这些方法在模拟，幻影和盲目观察者临床研究中表明明显与传统超声图像相比，图像质量改善了，尤其是在难以摄制的患者中。我们建议将连贯成像的理论扩展到1.5D和2D阵列，并扩展到非常大的阵列。使用这样的高级阵列，我们提出临床研究来评估相干成像在孕早期和妊娠中期扫描中的关键胎儿诊断任务。定量图像质量提出指标和观察者研究以比较B模式和相干图像与强调当前成像方法失败的难以模仿的患者。相关研究将测量胎儿扫描中各种图像降解来源的贡献。如果成功，拟议的研究可能会导致一类新的超声波束成式方法当前方法失败的成像环境。