Coherence-Based Fetal Ultrasonic Imaging

基于相干性的胎儿超声成像

基本信息

批准号：
10570866
负责人：
Gregg E. Trahey
金额：
$ 49.47万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2026-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10570866
关键词：
Abdomen Affect Aneuploidy Anxiety Blinded Cardiac Cesarean section Clinical Research Clutterings Congenital diaphragmatic hernia Counseling Data Detection Developed Countries Diagnosis Diagnostic Diffuse Discipline of obstetrics Environment Failure Fetal Development Fetal Growth Fetal Monitoring Fetal Structures Fetal Viability Fetal health Fetus First Pregnancy Trimester Frequencies Gestational Age Human Image Image Analysis Imaging Techniques Life Location Maps Maternal Health Measures Methods Morbidity - disease rate Mothers Multiple Pregnancy Noise Obesity Operative Surgical Procedures Ovary Overweight Pathology Patient imaging Patients Pelvis Placenta Pregnancy Property Publishing Research Resolution Role Scanning Second Pregnancy Trimester Source Structure Sum Techniques Translations Ultrasonics Ultrasonography United States Uterus Visualization Woman comparative cost fetal follow-up imaging modality improved in vivo maternal outcome mortality neonate novel postnatal public health relevance quantitative imaging simulation tertiary care theories ultrasound unnecessary treatment

项目摘要

Abstract Ultrasonic imaging is widely used to monitor fetal growth and development during the first and second trimester, and multiple studies document the resultant positive impacts on fetal and maternal outcomes. However, current methods fail to provide adequate visualization of key structures in many patients, and alternative imaging modes are rarely available to these patients. We have developed novel ultrasonic beamforming methods that utilize the spatial coherence of backscattered echoes. These methods, in simulation, phantom, and blinded-observer clinical studies, show markedly improved image quality over conventional ultrasonic images, especially in difficult-to-image patients. We propose extend our theory of coherence imaging to 1.5D and 2D arrays and to very large arrays. Using such advanced arrays, we propose clinical studies to assess the role of coherence imaging in key fetal diagnostic tasks in first trimester and second trimester scans. Quantitative image quality metrics and observer studies are proposed to compare B-mode and coherence images with an emphasis on difficult-to-image patients for whom current imaging methods fail. Related studies will measure the contribution of various sources of image degradation in fetal scans. If successful, the proposed research could lead to a new class of ultrasonic beamforming methods that operate in imaging environments in which current methods fail.

抽象的超声波成像广泛用于监测胎儿第一胎和第二胎的生长发育妊娠期，多项研究记录了对胎儿和母亲的积极影响结果。然而，当前的方法无法提供许多关键结构的充分可视化患者，并且这些患者很少可以使用替代成像模式。我们开发了利用反向散射回波的空间相干性的新型超声波波束形成方法。这些方法在模拟、模型和盲法观察者临床研究中显着地表明与传统超声图像相比，图像质量得到改善，尤其是难以成像的患者。我们建议将相干成像理论扩展到 1.5D 和 2D 阵列以及非常大的阵列。使用这种先进的阵列，我们提出临床研究来评估相干成像在妊娠早期和中期扫描中的关键胎儿诊断任务。定量图像质量提出了度量和观察者研究来将 B 模式和相干图像与重点关注当前成像方法失败的难以成像的患者。相关研究将测量胎儿扫描中图像劣化的各种来源的贡献。如果成功的话，拟议的研究可能会产生一类新型超声波波束形成方法，该方法可在当前方法失败的成像环境。