Acoustic Radiation Force Impulse (ARFI) Imaging of Cardiac Tissue

心脏组织的声辐射力脉冲 (ARFI) 成像

• 批准号: 8665516
• 负责人: Gregg E. Trahey
• 金额: $ 49.34万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8665516
• 关键词: Acoustics; Adult; Animal Model; Animals; Anisotropy; Canis familiaris; Cardiac; Cardiac ablation; Cardiology; Childhood; Cicatrix; Clinical Research; Data; Development; Diagnosis; Diagnostic; Diastolic heart failure; Early Diagnosis; Echocardiography; Fiber; Graft Rejection; Heart; Heart Diseases; Heart Transplantation; Heart failure; Human; Image; Imaging Techniques; Infarction; Label; Lesion; Measurement; Measures; Mechanics; Methods; Metric; Modality; Modeling; Motion; Myocardial; Myocardial Contraction; Myocardial Ischemia; Myocardial tissue; Physiologic pulse; Physiological; Property; Radiation; Resolution; Role; Severities; Stimulus; Techniques; Testing; Time; Tissues; Transplant Recipients; Transplantation; Ultrasonics; Ultrasonography; Variant; abstracting; flexibility; heart function; image processing; imaging modality; improved; in vivo; instrumentation; novel; pressure; response; signal processing; success; tool; two-dimensional

Abstract Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.

抽象的 几乎每种形式的心脏病都涉及心肌硬度的变化。 目前临床上可行的评估心肌僵硬度的测量技术是 它们是侵入性的和/或涉及图像衍生的指标。我们建议使用新的成像技术 方法，称为声辐射力脉冲（ARFI）成像，在测量me- 心肌组织的力学特性。该技术利用超声波辐射力 来置换组织。然后使用常规超声波来观察 组织力。我们提供的初步数据表明该技术在 对正常心肌功能下发生的硬度变化进行成像。我们亲 进一步开发 ARFI 成像技术并研究 ARFI 的使用 使用动物模型进行成像检测异常心脏功能。此外，我们还亲 对儿科心脏移植患者进行人体临床研究。这些研究将 评估 ARFI 成像提供移植排斥早期检测的潜力， 对心力衰竭的严重程度进行分级，以及区分收缩压和舒张压 心脏衰竭。