Reward responsivity and depression in autism spectrum disorder: A multimethod approach

自闭症谱系障碍中的奖励反应和抑郁：多种方法

• 批准号: 10571567
• 负责人: Jessica M Schwartzman
• 金额: $ 16.04万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10571567
• 关键词: 17 year old; Adolescence; Adolescent; Adult; Behavioral; Biological Markers; Clinical; Complex; Development; Development Plans; Developmental Course; Diagnostic; Early Diagnosis; Early Intervention; Electroencephalography; Employment; Event-Related Potentials; Face; Family member; Future; Goals; High Prevalence; Impairment; Intervention; Interview; Investigation; Knowledge; Literature; Maintenance; Measurement; Measures; Mental Depression; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Methodology; Methods; Modeling; Mood Disorders; National Institute of Mental Health; Neurobiology; Outcome; Pathway interactions; Population; Positive Valence; Prevalence; Provider; Psychophysiology; Quality of life; Research; Research Domain Criteria; Rewards; Risk; Risk Factors; Sampling; Schedule; Schizophrenia; Schools; Severities; Social Interaction; Social Processes; Strategic Planning; Symptoms; Techniques; Testing; Time; Training; Translating; Translational Research; Vulnerable Populations; Work; adolescent with autism spectrum disorder; autism spectrum disorder; career; career development; child depression; clinical translation; depressive symptoms; emotional experience; experience; follow-up; high risk; longitudinal analysis; longitudinal design; method development; mortality risk; neural; neurophysiology; novel; peer; physical conditioning; premature; prospective; recruit; response; screening; social; social communication; suicidal morbidity; symptomatology; therapy development

PROJECT SUMMARY Adolescents with Autism Spectrum Disorder experience depression at rates nearly twice that of their neurotypical peers (20% vs. 11%). Untreated depression is associated with adverse short (e.g., school refusal) and long-term outcomes (e.g., poor physical health, lower employment) that impair quality of life. Adolescents with autism also face a 10x increase in the risk for premature death by suicide than their neurotypical peers. Risk factors to depression in autism are not well understood and measurement efforts may be complicated by social communication difficulties (i.e., autism symptomatology) that complicate adolescents’ efforts to identify and explain emotional experiences to providers and family members. Therefore, more objective measures (e.g., electroencephalogram [EEG], specifically event-related potentials [ERPs]) may provide a better understanding of risk factors to depression in adolescents with autism. Altered reward responsivity (Research Domain Criteria [RDoC] Positive Valence) and disrupted social processes (RDoC Affiliation and Attachment) are key risk factors to depression for neurotypical adolescents, but have not been investigated in autism. Clinical and neural measures of social and nonsocial reward responsivity and associations with depression symptoms have not been examined in autism, which may provide meaningful information about developmental trajectories. Consistent with the NIMH Strategic Plan, Strategic Goal 2, “to identify and understand risk factors, biomarkers and behavioral indicators of mental illness,” this K23 application aims to examine clinical and neural markers of social and nonsocial reward responsivity and associations with depression symptoms in adolescents with autism, including longitudinal investigations. Under the mentorship of a diverse team of experts in autism, depression, reward responsivity, psychophysiological methods, and longitudinal and statistical methodologies, this proposal will examine the predictive influences of these RDoC constructs to depression in adolescents 14-17 years old with autism. Adolescence is a key developmental period for early detection and intervention as it is characterized by spikes in depression prevalence and an increasing importance of peer relationships. Specifically, this proposal will use EEG/ERP techniques and clinician-rated interviews to measure social and nonsocial reward responsivity in adolescents with autism and test relationships with depression symptoms. Adolescents will be assessed one year later to investigate how clinical and neural measures predict depression symptoms over time, which will inform the developmental course of these RDoC constructs in this vulnerable population. The applicant’s long- term goal is to understand the neurobiological and behavioral development of reward responsivity in autism and associations with depression from adolescence to adulthood so as to inform screening methods and intervention development. Mentored training will allow the applicant to gain expertise in multimethod measures (e.g., ERP methodologies, clinician-rated interviews) and longitudinal design and analysis, with an emphasis on assessing mechanisms associated with the onset, maintenance, and treatment of depression in autism.

项目摘要 自闭症谱系障碍的青少年经历抑郁症的速度几乎是其神经型的两倍 同龄人（20％比11％）。未经治疗的抑郁症与不利的短暂（例如，学校垃圾）和长期有关 损害生活质量的结果（例如身体健康状况不佳，就业较低）。自闭症的青少年 与神经型同龄人相比，自杀过早死亡的风险面临10倍。风险因素 自闭症中的抑郁症尚未得到充分的理解，社会的测量工作可能使人复杂 沟通困难（即自闭症症状学）使青少年识别和 explain emotional experiences to providers and family members. Therefore, more objective measures (e.g., electroencephalogram [EEG], specifically event-related potentials [ERPs]) may provide a better understanding of risk factors to depression in adolescents with autism. Altered reward responsivity (Research Domain Criteria [RDoC] Positive Valence) and disrupted social processes (RDoC Affiliation and Attachment) are key risk factors to depression for neurotypical adolescents, but have not been investigated in autism. Clinical and neurotypical Measures of social and nonsocial reward responsivity and associations with depression symptoms have not was examined in autism, which may provide meaningful information about developmental trajectories. Consistent with the NIMH Strategic Plan, Strategic Goal 2, “to identify and understand risk factors, biomarkers and behavioral indicators of mental illness," this K23 application aims to examine clinical and neural markers of social and nonsocial reward responsivity and associations with depression symptoms in adolescents with autism, including longitudinal investigations. Under the mentality of a divers team of experts in autism, depression, reward responsivity, psychophysiological methods, and longitudinal and statistical methods, this proposal will examine the predictive influences of these RDoC constructs to depression in adolescents 14-17 years old with autism. Adolescente is a key developmental period for early detection and intervention as it is characterized by spikes in depression prevalence and an increasing importance of peer relationships.具体来说，该提议 will use EEG/ERP techniques and clinical-rated interviews to measure social and non-social reward rewardsivity in adolescents with autism and test relationships with depression symptoms. Adolescents will be assessed one year later to investigate how clinical and neuromeasures predict depression symptoms over time, which will inform the developmental course of these RDoC constructs in this vulnerable population. The applicant’s long- term goal is to understand the neurobiological and behavioral development of reward responsivity in autism and associations with depression from adolescente to adulthood so as to inform screening methods and intervention 发展。 Mentored training will allow the applicant to gain expertise in multimethod measures (e.g., ERP methods, clinical-rated interviews) and longitudinal design and analysis, with an emphasis on assessment mechanisms associated with the onset, maintenance, and treatment of depression in autism.