REGISTRATION, STORAGE AND DISTRIBUTION OF CHEMICALS AND DRUGS FOR PRE-CLINICAL DISCOVERY EVALUATION AND DEVELOPMENT

用于临床前发现评估和开发的化学品和药物的注册、储存和分配

• 批准号: 10577410
• 负责人: MARK LEE
• 金额: $ 255.77万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10577410
• 关键词: Archives; Biological; Chemicals; Contractor; Contracts; Data; Databases; Development; Developmental Therapeutics Program; Division of Cancer Treatment and Diagnosis; Equipment and supply inventories; Evaluation; Extramural Activities; Goals; National Cancer Institute; National Institute of Allergy and Infectious Disease; Natural Products; Pharmaceutical Preparations; Preclinical Drug Evaluation; Program Evaluation; Research; Research Personnel; Sampling; Screening for cancer; Services; Shipping; Therapeutic Agents; Therapeutics for Rare and Neglected Diseases; United States National Institutes of Health; Update; anti-cancer; chemotherapeutic agent; drug synthesis; flexibility; pre-clinical; programs; repository; small molecule; small molecule therapeutics

The Drug Synthesis and Chemistry Branch (DSCB) of the Developmental Therapeutics Program (DTP) of the Division of Cancer Treatment and Diagnosis (DCTD) of the National Cancer Institute (NCI) support services to operate and maintain the National Cancer Institute's Chemotherapeutic Agents Repository (NCI-CAR). The principal goal of this contract is to support the handling of the chemical compounds and related data for the DTP anticancer pre-clinical drug evaluation program which seeks to identify new small molecule therapeutic agents. The primary tasks of the contract are the receipt, registration, storage, analysis, arraying and distribution of small molecules and purified natural products that will be evaluated in DTP anti-cancer screens, and also distributed to extramural researchers. In addition, a small number of compounds from other NIH (e.g. NIAID, NExT, TRND) programs may be handled through this contract.

美国国家癌症研究所 (NCI) 癌症治疗和诊断部门 (DCTD) 发展治疗计划 (DTP) 的药物合成和化学分部 (DSCB) 支持运行和维护国家癌症研究所化疗药物存储库的服务 ( NCI-CAR）。该合同的主要目标是支持 DTP 抗癌临床前药物评估项目的化合物和相关数据的处理，该项目旨在识别新的小分子治疗药物。合同的主要任务是接收、注册、存储、分析、排列和分发小分子和纯化的天然产品，这些小分子和纯化的天然产品将在 DTP 抗癌筛选中进行评估，并分发给校外研究人员。此外，来自其他 NIH（例如 NIAID、NExT、TRND）项目的少量化合物也可以通过本合同进行处理。