CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

化学筛选和优化设施 - 管理、行政和数据库核心功能活动

• 批准号: 10942871
• 负责人: LEYI GONG
• 金额: $ 32.67万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-27 至 2024-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10942871
• 关键词: Adenomyosis; Archives; Bacterial Infections; Biological; Chemicals; Contraceptive Agents; Contraceptive methods; Data; Databases; Down Syndrome; Dysmenorrhea; Equipment; Equipment and supply inventories; Fetal Growth Retardation; Fibroid Tumor; Gestational Diabetes; Gynecologic; Health; Infertility; Inflammation; Lactation; Maintenance; Mission; Muscular Dystrophies; National Institute of Child Health and Human Development; Natural Products; Necrotizing Enterocolitis; Pelvic Pain; Perinatal; Pituitary-dependent Cushing' s disease; Placenta; Polycystic Ovary Syndrome; Polymers; Pre-Eclampsia; Premature Birth; Production; Reproductive Health; Research; Rett Syndrome; Role; Sepsis; United States National Institutes of Health; Virus Diseases; Vulvodynia; autism spectrum disorder; drug development; endometriosis; improved; in vivo evaluation; mastitis; microbiome; novel; screening; small molecule; Adenomyosis; Archives; Bacterial Infections; Biological; Chemicals; Contraceptive Agents; Contraceptive methods; Data; Databases; Down Syndrome; Dysmenorrhea; Equipment; Equipment and supply inventories; Fetal Growth Retardation; Fibroid Tumor; Gestational Diabetes; Gynecologic; Health; Infertility; Inflammation; Lactation; Maintenance; Mission; Muscular Dystrophies; National Institute of Child Health and Human Development; Natural Products; Necrotizing Enterocolitis; Pelvic Pain; Perinatal; Pituitary-dependent Cushing' s disease; Placenta; Polycystic Ovary Syndrome; Polymers; Pre-Eclampsia; Premature Birth; Production; Reproductive Health; Research; Rett Syndrome; Role; Sepsis; United States National Institutes of Health; Virus Diseases; Vulvodynia; autism spectrum disorder; drug development; endometriosis; improved; in vivo evaluation; mastitis; microbiome; novel; screening; small molecule

This task is to conduct the core administrative activities, including project management, as well as storage of chemical and biological inventory, archived documents and data, maintenance of equipment, and continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF) to support the mission of contraceptive drug development in the Contraception Research Branch (CRB), NICHD, NIH. The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to conduct scalable quantity projects of identified small molecule(s) (e.g., natural product) and/or large molecule (e.g., polymer) that afford a contraceptive effect against a validated target or as a treatment for an identified reproductive health related indication. This facility will also be responsible for the production of chemical material for preliminary in vivo testing. It is expected that multiple independent projects will be performed simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful execution.

这项任务是进行包括项目管理在内的核心行政活动，以及化学和生物库存的存储，存档的文档和数据，设备的维护以及在化学筛选和优化设施（CSOF）中持续的数据库维护活动（CSOF），以支持避孕研究分支（CRB），NICHD，NICHD，NICH，NIHH，NIH。 化学筛查和优化设施（CSOF）通过识别，优化和进行生产确定了与避孕和生殖健康相关的小分子（例如，不育，多囊卵巢综合征，成纤维综合征，成纤维，成纤维，子宫内膜异位虫，肌动蛋白疗法，肾上腺菌皮和/果皮疾病，疾病，卵巢疾病，卵巢疾病，卵巢疾病，糖尿病，疾病疾病，疾病疾病疾病，疾病疾病疾病疾病。 birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, RETT综合征，败血症或自闭症研究。一种方法是进行可识别的小分子（例如天然产物）和/或大分子（例如聚合物）的可扩展数量项目，这些分子（例如聚合物）对经过验证的靶标具有避孕作用，或作为对鉴定的生殖健康相关指示的治疗方法。 该设施还将负责生产初步体内测试的化学材料。预计将由CSOF同时执行多个独立项目。对这些项目的适当监督对于他们的成功执行至关重要。