CHEMICAL SCREENING AND OPTIMIZATION FACILITY - PROTEIN EXPRESSION AND/OR X-RAY CRYSTALLOGRAPHY

化学筛选和优化设施 - 蛋白质表达和/或 X 射线晶体学

基本信息

批准号：
10942884
负责人：
LEYI GONG
金额：
$ 26.12万
依托单位：
SRI INTERNATIONAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-29 至 2026-09-27
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10942884
关键词：
Adenomyosis Bacterial Infections Chemicals Contraceptive Agents Contraceptive methods Contracts Crystallization Data Development Down Syndrome Dysmenorrhea Fetal Growth Retardation Fibroid Tumor Generations Gestational Diabetes Gynecologic Health Infertility Inflammation Lactation Muscular Dystrophies National Institute of Child Health and Human Development Necrotizing Enterocolitis Pelvic Pain Peptides Performance Perinatal Pituitary-dependent Cushing&apos s disease Placenta Polycystic Ovary Syndrome Pre-Eclampsia Premature Birth Production Proteins Recombinant Proteins Reproductive Health Research Resolution Rett Syndrome Role Sampling Sepsis Structure United States National Institutes of Health Virus Diseases Vulvodynia Work X-Ray Crystallography autism spectrum disorder endometriosis improved inhibitor interest mastitis microbiome protein expression protein purification screening small molecule

Adenomyosis Bacterial Infections Chemicals Contraceptive Agents Contraceptive methods Contracts Crystallization Data Development Down Syndrome Dysmenorrhea Fetal Growth Retardation Fibroid Tumor Generations Gestational Diabetes Gynecologic Health Infertility Inflammation Lactation Muscular Dystrophies National Institute of Child Health and Human Development Necrotizing Enterocolitis Pelvic Pain Peptides Performance Perinatal Pituitary-dependent Cushing&apos s disease Placenta Polycystic Ovary Syndrome Pre-Eclampsia Premature Birth Production Proteins Recombinant Proteins Reproductive Health Research Resolution Rett Syndrome Role Sampling Sepsis Structure United States National Institutes of Health Virus Diseases Vulvodynia Work X-Ray Crystallography autism spectrum disorder endometriosis improved inhibitor interest mastitis microbiome protein expression protein purification screening small molecule

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项目摘要

The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to perform x-ray crystallography studies with active target proteins or peptides in the presence or absence of chemical entities of interest. The research contained within this task order will encompass generation and purification of proteins or peptides of interest, development of crystals, and structural analysis by x-ray crystallography.

化学筛查和优化设施（CSOF）通过识别，优化和进行生产确定了与避孕和生殖健康相关的小分子（例如，不育，多囊卵巢综合征，成纤维综合征，成纤维，成纤维，子宫内膜异位虫，肌动蛋白疗法，肾上腺菌皮和/果皮疾病，疾病，卵巢疾病，卵巢疾病，卵巢疾病，糖尿病，疾病疾病，疾病疾病疾病，疾病疾病疾病疾病。 birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, RETT综合征，败血症或自闭症研究。一种方法是在存在或不存在感兴趣的化学实体的情况下，使用活性靶蛋白或肽进行X射线晶体学研究。该任务顺序中包含的研究将涵盖蛋白质或感兴趣的蛋白质的产生和纯化，晶体的发展以及X射线晶体学的结构分析。