ACETAMINOPHEN (TYLENOL?) INDUCED HUMAN LYMPHOCYTE TOXICITY

对乙酰氨基酚（泰诺？）引起的人体淋巴细胞毒性

• 批准号: 7716902
• 负责人: PAUL B WATKINS
• 金额: $ 0.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-02 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716902
• 关键词: Acetaminophen; Biological Assay; Cell Survival; Computer Retrieval of Information on Scientific Projects Database; Flow Cytometry; Funding; Grant; Human; In Vitro; Institution; Learning; Lymphocyte; Methods; Participant; Peripheral; Procedures; Purpose; Research; Research Personnel; Resources; Source; Toxic effect; Tylenol; United States National Institutes of Health; cell injury; design; drug mechanism; healthy volunteer; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: This study was designed to learn more about potential mechanisms of drug-induced cellular injury. Human lymphocytes from healthy volunteers will be obtained. In-vitro experiments will be carried out in peripheral lymphocytes to assess intra-subject and inter-subject variability in sensitivity to acetaminophen toxicity. Participants: 100 Healthy Volunteers Procedures (methods): In vitro cell viability assays and flow cytometry will be used to assess lymphocyte sensitivity to toxicity caused by acetaminophen

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：本研究旨在更多地了解药物引起的细胞损伤的潜在机制。 将从健康志愿者身上获得人类淋巴细胞。 将在外周淋巴细胞中进行体外实验，以评估受试者体内和受试者之间对对乙酰氨基酚毒性敏感性的变异性。 参加者：100名健康志愿者 程序（方法）：体外细胞活力测定和流式细胞术将用于评估淋巴细胞对对乙酰氨基酚引起的毒性的敏感性