NEUROIMAGING IN THE OKLAHOMA FAMILY HEALTH PATTERNS PROJECT

俄克拉荷马州家庭健康模式项目中的神经影像

• 批准号: 7718752
• 负责人: William R Lovallo
• 金额: $ 0.03万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718752
• 关键词: Alcohol abuse; Alcohol consumption; Alcoholism; Behavioral; Brain region; Computer Retrieval of Information on Scientific Projects Database; Disinhibition; Emotions; Face; Family health status; Family history of; Functional Magnetic Resonance Imaging; Funding; Grant; Individual; Institution; Limbic System; Measures; Oklahoma; Pattern; Persons; Relative (related person); Research; Research Personnel; Resources; Risk; Source; Stimulus; Testing; United States National Institutes of Health; alcohol use disorder; clinically relevant; cohort; design; neuroimaging; research study; response; willingness

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 2007 OBJECTIVE: A positive family history of alcoholism (FH+) and behavioral disinhibition are both associated with increased risk of developing an alcohol use disorder. The Oklahoma Family Health Patterns project was designed to study healthy, nonabusing FH+ persons who also display evidence of behavioral undercontrol (High Risk). We hypothesize that these High-Risk persons will demonstrate altered limbic system activity in response to emotionally significant stimuli, relative to Low-Risk individuals (FH- and lacking in behavioral undercontrol). RESEARCH PLAN AND METHODS: To test this assertion, we will carry out a targeted fMRI experiment on High-Risk persons and Low Risk persons chosen from a larger cohort in the primary study. The subjects will participate in a facial recognition task using faces displaying negative emotions and regions of brain activation will be measured. CLINICAL RELEVANCE: Limbic hyporesponsiveness may be associated with a willingness to make risky decisions about alcohol intake increasing the person's liability for alcohol abuse.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 2007年 目的：阳性家族酗酒史（FH+）和行为去抑制都与罹患酒精使用障碍的风险增加相关。 俄克拉荷马州家庭健康模式项目旨在研究健康、无虐待行为的 FH+ 人群，这些人群也表现出行为控制不足（高风险）的证据。 我们假设，相对于低风险个体（FH 且行为失控），这些高风险个体将表现出边缘系统活动的改变，以应对情绪上显着的刺激。 研究计划和方法：为了验证这一论断，我们将对主要研究中较大人群中选择的高风险人群和低风险人群进行有针对性的功能磁共振成像实验。 受试者将使用表现出负面情绪的面孔参与面部识别任务，并测量大脑激活区域。 临床相关性：边缘系统反应低下可能与愿意做出关于酒精摄入的危险决定有关，从而增加了人酗酒的可能性。