METHYLPHENIDATE-ETHANOL INTERACTIONS IN ADHD AND CO-ABUSE

哌醋甲酯-乙醇在多动症和共同滥用中的相互作用

• 批准号: 7719605
• 负责人: KENNERLY Sexton PATRICK
• 金额: $ 0.08万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719605
• 关键词: Alcohol consumption; Alcohols; Attention deficit hyperactivity disorder; Blood Circulation; Computer Retrieval of Information on Scientific Projects Database; Ethanol; Funding; Grant; Human; Institution; Isomerism; Marketing; Medical; Methylphenidate; Pharmaceutical Preparations; Purpose; Research; Research Personnel; Resources; Ritalin; Schedule; Source; United States National Institutes of Health; Woman; dexmethylphenidate; drinking; ethylphenidate; men; prescription document; prescription procedure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to determine if there are differences in the amount of Ritalin or Focalin absorbed depending on whether alcohol is also administered. Recently, an MUSC study has found that when the prescription Attention Deficit/Hyperactivity Disorder (ADHD) medication Ritalin (generically called dl-methylphenidate) is combined with a drink containing ethyl alcohol (drinking alcohol), the alcohol increases the amount of Ritalin absorbed from the gut into the bloodstream. Also, humans were found to form a Ritalin -alcohol product called ethylphenidate. The Drug Enforcement Administration classifies both Ritalin , and the pure d-isomer form of methylphenidate marketed as Focalin (generically called dexmethylphenidate), as Schedule II drugs. This means that these drugs have a high abuse potential while still being recognized as possessing beneficial medical uses, e.g., to treat ADHD. Further, the extent of ethylphenidate formation will be established, as well as potential differences between men and women.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是确定利他林或福卡林的吸收量是否因是否同时饮酒而存在差异。最近，MUSC 的一项研究发现，当注意力缺陷/多动症 (ADHD) 处方药利他林（通常称为 dl-哌醋甲酯）与含有乙醇的饮料（饮酒）结合使用时，酒精会增加从身体中吸收的利他林量。肠道进入血液。此外，人们还发现人类可以形成一种名为哌乙酯的利他林酒精产品。缉毒局将利他林和以 Focalin 销售的纯 d 异构体形式的哌甲酯（通常称为右哌甲酯）归类为附表 II 药物。这意味着这些药物具有很高的滥用潜力，同时仍然被认为具有有益的医疗用途，例如治疗多动症。 此外，还将确定哌乙酯形成的程度以及男性和女性之间的潜在差异。