Biobehavioral Effects of Qigong During Treatment for Rectal Cancer

气功治疗直肠癌的生物行为效应

• 批准号: 7591776
• 负责人: Lorenzo Cohen
• 金额: $ 21.89万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7591776
• 关键词: Acute; Adjuvant; Adverse effects; Aftercare; Anxiety; Attention; Breathing; Buffers; Cancer Patient; Cessation of life; Client satisfaction; Cognitive; Combined Modality Therapy; Control Groups; Desire for food; Diagnosis; Disease Progression; Distress; Dose; Educational process of instructing; Emotional; Evaluation; Exercise; Fatigue; Frequencies; Fright; Health; Hospitals; Intestines; Light Exercise; Malignant Neoplasms; Measures; Mediator of activation protein; Meditation; Mental Health; Morbidity - disease rate; Movement; Operative Surgical Procedures; Participant; Patients; Physical Function; Physiological; Pilot Projects; Population; Postoperative Period; Process; Psyche structure; Psychological Side Effects; Qi; Qi Gong; Quality of life; Questionnaires; Radiation; Radiation therapy; Radiation-Sensitizing Agents; Randomized; Recovery; Rectal Cancer; Recurrence; Relaxation Techniques; Reporting; Research; Schedule; Sexual Dysfunction; Skin; Sleep disturbances; Social Functioning; Social support; Source; Spirituality; Staging; Stress; Stretching; Structure; Techniques; Testing; Time; Treatment Protocols; Treatment-Related Cancer; Visit; biobehavior; cancer therapy; chemotherapy; coping; depression; experience; follow up assessment; improved; indexing; interest; programs; psychologic; public health relevance; social; stress management; stressor; treatment effect; treatment planning; visual imagery; Acute; Adjuvant; Adverse effects; Aftercare; Anxiety; Attention; Breathing; Buffers; Cancer Patient; Cessation of life; Client satisfaction; Cognitive; Combined Modality Therapy; Control Groups; Desire for food; Diagnosis; Disease Progression; Distress; Dose; Educational process of instructing; Emotional; Evaluation; Exercise; Fatigue; Frequencies; Fright; Health; Hospitals; Intestines; Light Exercise; Malignant Neoplasms; Measures; Mediator of activation protein; Meditation; Mental Health; Morbidity - disease rate; Movement; Operative Surgical Procedures; Participant; Patients; Physical Function; Physiological; Pilot Projects; Population; Postoperative Period; Process; Psyche structure; Psychological Side Effects; Qi; Qi Gong; Quality of life; Questionnaires; Radiation; Radiation therapy; Radiation-Sensitizing Agents; Randomized; Recovery; Rectal Cancer; Recurrence; Relaxation Techniques; Reporting; Research; Schedule; Sexual Dysfunction; Skin; Sleep disturbances; Social Functioning; Social support; Source; Spirituality; Staging; Stress; Stretching; Structure; Techniques; Testing; Time; Treatment Protocols; Treatment-Related Cancer; Visit; biobehavior; cancer therapy; chemotherapy; coping; depression; experience; follow up assessment; improved; indexing; interest; programs; psychologic; public health relevance; social; stress management; stressor; treatment effect; treatment planning; visual imagery

DESCRIPTION (provided by applicant): Cancer and its treatment are associated with considerable distress, impaired quality of life, poor mental health, and reduced physical function. This is particularly true for patients with rectal cancer who receive multimodal treatment over an extended period of time. Most patients will undergo radiotherapy, followed by surgery and often chemotherapy. It is important to develop programs that can help ameliorate the treatment-related morbidity that accumulates over time for patients with rectal cancer. Furthermore, given the stressful time demands of undergoing radiotherapy (patients typically receive treatment 5 days per week for 6 weeks) it is crucial that programs be easily incorporated into the treatment schedule. Research suggests that stress- reduction programs tailored to the cancer setting help patients cope with the acute effects of treatment and improve QOL after treatment. Qigong, an ancient practice for manipulating one's own Qi (energy flow) to benefit one's physical, emotional, mental, or spiritual health incorporates stress-reduction techniques including regulated breathing, visual imagery, meditation, and various gentle movements. Qigong may be particularly useful for patients with rectal cancer while undergoing radiation treatment and prior to surgery and chemotherapy because of the stress management and relaxation techniques and the gentle movements that should facilitate recovery. In this feasibility/pilot project, we will pilot-test and examine the feasibility and usefulness of conducting a Qigong program with rectal cancer patients as an adjuvant to their radiotherapy treatment. Rectal cancer patients undergoing radiotherapy treatment will be randomly assigned Patients with rectal cancer who are undergoing chemo-radiotherapy will be randomly assigned to either a Qigong group (QI), or a light exercise control group (LE), or a waitlist control group (WL). Participants in the QI and LE groups will attend sessions 3 days/week throughout their 6-week radiotherapy schedule. The sessions will be coordinated with the treatment schedule and conducted adjacent to the treatment facility. Measures will be obtained prior to randomization, a brief assessment in the middle of radiotherapy, during last week of radiotherapy, and 1 and 3 months after the end of radiotherapy. In addition to determining the acceptability and feasibility of the program, this study will also examine the effects of the Qigong program on fatigue and sleep disturbances. Secondary indices of adjustment include QOL and mental health. We hypothesize that the Qigong program will be feasible and that patients will find the program acceptable and a positive experience. Integrating a Qigong program into the treatment regimen for patients undergoing radiotherapy will make it relatively easy to participate in the program and we hypothesize that such a program will help facilitate recovery and alleviate the psychological and physiological side effects experienced by patients who are currently undergoing radiotherapy. Public Health Relevance Paragraph: The proposed study will examine the feasibility and initial usefulness of incorporating a Qigong program alongside radiotherapy for patients with rectal cancer. If we find that the Qigong program facilitates recovery and alleviates the psychological and physiological side effects experienced by patients undergoing radiotherapy then this type of program can be incorporated into the treatment plan. As the proposed trial is a feasibility/pilot project a larger trial would need to be conducted and possibly include other cancer populations undergoing radiotherapy.

描述（由申请人提供）：癌症及其治疗与相当大的困扰，生活质量受损，精神健康不良和身体机能减少有关。对于长时间接受多模式治疗的直肠癌患者尤其如此。大多数患者将接受放疗，然后进行手术和通常化疗。重要的是要开发可以帮助改善与治疗相关的发病率的计划，从而为直肠癌患者累积了随着时间的流逝而积累。此外，鉴于接受放射治疗的压力时间（通常每周5天治疗6周）的压力时间很高，因此很容易将程序纳入治疗时间表至关重要。研究表明，量身定制的针对癌症设置的压力减轻计划有助于患者应对治疗的急性影响并改善治疗后的QOL。气功，一种古老的做法，用于操纵自己的气（能量流），以使自己的身体，情感，心理或精神健康受益，其中包括减轻压力的技术，包括受调节的呼吸，视觉图像，冥想和各种温和运动。气功可能对直肠癌患者特别有用，同时接受放射治疗，并且在手术和化学疗法之前进行了压力管理和放松技术以及应促进康复的轻柔运动。在这个可行性/试点项目中，我们将进行试点测试并检查与直肠癌患者进行气功计划的可行性和实用性，作为其放射治疗的辅助药物。接受放疗治疗的直肠癌患者将是随机分配的直肠癌患者，他们正在接受化学疗法的患者将随机分配给气功组（QI）或轻运动对照组（LE）或侍应列表控制组（WL）。 QI和LE小组的参与者将在6周的放射疗法计划中参加3天/周的课程。课程将与治疗时间表协调，并在治疗设施附近进行。在放射疗法的最后一周，放射疗法的最后一周以及放疗结束后的1和3个月，将在随机分组之前获得措施。除了确定程序的可接受性和可行性外，本研究还将检查气功计划对疲劳和睡眠障碍的影响。调整的次要指标包括QOL和心理健康。我们假设气功计划将是可行的，并且患者会发现该计划可以接受和积极的经验。将气功计划整合到接受放射疗法的患者的治疗方案中，将使参与该计划相对容易，我们假设这样的计划将有助于促进康复并减轻目前正在放射治疗的患者所经历的心理和生理副作用。 公共卫生相关性段落：拟议的研究将检查将气功计划与放射疗法同时纳入直肠癌患者的可行性和最初有用性。如果我们发现气功计划有助于康复并减轻接受放射治疗的患者所经历的心理和生理副作用，那么可以将这种类型的程序纳入治疗计划中。由于拟议的试验是一个可行性/试验项目，需要进行更大的试验，并可能包括接受放疗的其他癌症种群。