Brain Mechanisms of Anticipatory Processing in Anxiety Disorders

焦虑症预期处理的大脑机制

基本信息

批准号：
7895583
负责人：
Jack B Nitschke
金额：
$ 9.5万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7895583
关键词：
Address Adverse event Affect Amygdaloid structure Anterior Anxiety Anxiety Disorders Area Aversive Stimulus Brain Brain region Client Clinical Comorbidity Data Deep Brain Stimulation Defense Mechanisms Development Plans Diagnosis Diffusion Magnetic Resonance Imaging Disease Economic Burden Environment Event Exposure to Feeling hopeless Figs - dietary Fright Functional disorder Future Generalized Anxiety Disorder Hippocampus (Brain)Human Individual Insula of Reil Intervention Investigation Knowledge Laboratories Major Depressive Disorder Mental Depression Mental disorders Methods Modeling Neurobiology Neurosciences Research Obsessive-Compulsive Disorder Outcome Patients Pattern Pharmaceutical Preparations Population Post-Traumatic Stress Disorders Prefrontal Cortex Process Psychiatry Psychotherapy Recovery Recruitment Activity Reporting Research Research Personnel Residual state Resources Sampling Schools Services Specific Phobia Specificity Sum Symptoms System Testing Training Transcranial magnetic stimulation Uncertainty Work adverse outcome base career development cingulate cortex conditioned fear design emotional stimulus interest knowledge base neuromechanism novel strategies programs relating to nervous system response social tool white matter

项目摘要

DESCRIPTION (provided by applicant): Anxiety disorders are a debilitating form of mental illness that affect many people and carry a high societal and economic burden. A central feature of these disorders is the excessive anticipation of potential adverse outcomes. Considerable work in the candidate's and others' labs has identified multiple brain areas recruited during the anticipation of aversive events. The primary research objectives of this application are to probe these areas for abnormalities during anticipation in anxiety disorder patients and to examine the impact of uncertainty and uncontrollability, which figure prominently in anxiety. The planned research will also assess functional associations and white matter connections among the brain networks identified. In service of that, training in functional and structural connectivity methods is the major focus of the career development plan. These rapidly developing areas examining connectivity are an obvious next step for the candidate's research program and career development and will be crucial in his efforts to continue contributing to our developing knowledge base about brain function in anxiety. The environment is ideal for the pursuit of these research and career development objectives, with outstanding facilities, collaborators, and resources as well as a high degree of support from both the Department of Psychiatry and the Waisman Center. The proposed research will examine anticipatory function in generalized anxiety disorder and social anxiety disorder using a picture paradigm designed and developed in the candidate's laboratory over the past 7 years. The high levels of comorbidity with depression for these two anxiety disorders will be systematically investigated by including patients with major depressive disorder. The discovery of neural abnormalities in anticipatory processes should add to the body of work already being used in developing new clinical tools for directly targeting specific brain regions in anxiety and depression, such as transcranial magnetic stimulation, epidural electrocortical stimulation, and deep brain stimulation. Psychotherapy clients may benefit from greater focus of intervention strategies on anticipatory processes relevant to their symptoms. Research findings from the proposed project might have implications for determining which individuals would be likely to benefit from a particular treatment, building on recent findings by the candidate and his colleagues that greater anticipatory activity in the anterior cingulate predicts better response to an 8-week medication trial.

描述（由申请人提供）：焦虑症是一种令人衰弱的精神疾病形式，影响了许多人并承担着很高的社会和经济负担。这些疾病的一个主要特征是对潜在不利结果的过度预期。候选人和其他实验室的大量工作已经确定了在厌恶事件期间招募的多个大脑区域。本应用的主要研究目标是在焦虑症患者预期期间对这些领域的异常进行探究，并检查不确定性和不可控制性的影响，这在焦虑中显着。计划的研究还将评估所确定的大脑网络之间的功能关联和白质连接。为此，功能和结构连接方法的培训是职业发展计划的主要重点。这些迅速发展的研究领域是候选人的研究计划和职业发展的明显下一步，对于他为继续为我们发展有关焦虑脑功能的知识基础的努力至关重要。该环境是追求这些研究和职业发展目标的理想选择，具有出色的设施，合作者和资源，以及精神病学系和Waisman中心的高度支持。拟议的研究将使用在过去7年中在候选人的实验室中设计和开发的图片范式检查普遍焦虑症和社交焦虑症中的预期功能。这两种焦虑症的高水平合并症与抑郁症的高度合并症将通过包括重度抑郁症患者包括在内。在预期过程中发现神经异常的发现应增加已用于开发新的临床工具的工作体系，以直接针对焦虑和抑郁症中的特定大脑区域，例如经颅磁刺激，硬膜外皮质刺激和深脑刺激。心理治疗客户可能会受益于更大的干预策略对与症状相关的预期过程的重点。拟议项目的研究结果可能对确定哪些人可能从特定治疗中受益，这是基于候选人及其同事的最新发现的基础，这些发现在前扣带回中有更大的预期活动可以预测对为期8周的药物试验的更好的反应。