VACCINE-ELICITED ANTIBODY DEPENDENT CELL CYTOTOXICITY IN PROTECTION AGAINST SIV

疫苗引发的抗体依赖性细胞毒性可预防 SIV

• 批准号: 7715609
• 负责人: Marta L Marthas
• 金额: $ 12.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715609
• 关键词: Antibodies; Cells; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HIV; HIV vaccine; Human Milk; Immunity; Infant; Institution; Macaca mulatta; Mediating; Neonatal; Oral; Oral cavity; Research; Research Personnel; Resources; SIV; Site; Source; Testing; United States National Institutes of Health; Vaccination; Vaccines; Virus; antibody-dependent cell cytotoxicity; killings; prevent; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To prevent HIV breast milk transmission, an HIV vaccine should elicit anti-HIV immunity at the initial site of virus exposure in the oral cavity as well as throughout the infants' body. This study tested the hypothesis that passively-transferred, SIV-specific antibodies elicited by vaccination and that can mediate killing of SIV-infected cells (Antibody Dependent Cellular Cytotoxicity, ADCC) may protect against oral SIV challenge of neonatal rhesus macaques.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：为了防止艾滋病毒母乳传播，艾滋病毒疫苗应在口腔和婴儿全身病毒暴露的最初部位引发抗艾滋病毒免疫力。这项研究测试了这样的假设：通过疫苗接种引发的被动转移的 SIV 特异性抗体可以介导杀死 SIV 感染细胞（抗体依赖性细胞毒性，ADCC），可以保护新生恒河猴免受口服 SIV 攻击。