EFFECT OF VISCERAL FAT ON INSULIN SENSITIVITY

内脏脂肪对胰岛素敏感性的影响

• 批准号: 7716173
• 负责人: RAUL A BASTARRACHEA
• 金额: $ 0.41万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716173
• 关键词: Adipose tissue; Computer Retrieval of Information on Scientific Projects Database; Excision; Fatty acid glycerol esters; Funding; Grant; Hypertension; Inflammation; Institution; Insulin; Intra-abdominal; Liver; Metabolic; Metabolic Diseases; Muscle; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Omentum; Overweight; Papio; Procedures; Research; Research Personnel; Resources; Risk; Risk Factors; Source; United States National Institutes of Health; Visceral; abdominal fat; improved; insulin sensitivity; male

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Excessive intra-abdominal (visceral) fat is associated with an increased risk of metabolic disease, including type 2 diabetes, dylipidemia, and hypertension. However, it is not known whether visceral fat is actually responsible for, or is simply associated with, these metabolic abnormalities. This proposal will evaluate the metabolic effects of decreasing intra-abdominal fat mass by resection of the omentum in overweight male baboons and will determine the mechanisms involved. It is expected that this procedure will result in improved muscle/adipose tissue and liver sensitivity to insulin (risk factors of type 2 diabetes), reduced levels of inflammation in the liver and muscle. Thus the information acquired will aid clinicians and researchers in focusing their efforts on reducing the societal burden of obesity-related metabolic disease.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 腹内（内脏）脂肪过多与代谢疾病的风险增加有关，包括 2 型糖尿病、血脂异常和高血压。然而，尚不清楚内脏脂肪是否真的导致这些代谢异常，或者仅仅与这些代谢异常有关。该提案将评估通过切除超重雄性狒狒的大网膜来减少腹内脂肪量的代谢效应，并确定所涉及的机制。预计该手术将改善肌肉/脂肪组织和肝脏对胰岛素的敏感性（2 型糖尿病的危险因素），降低肝脏和肌肉的炎症水平。因此，获得的信息将帮助临床医生和研究人员集中精力减轻肥胖相关代谢疾病的社会负担。