Reducing the Burden of Hepatocellular Carcinoma Among Migrant Populations: Improving prevention and outcomes through disease modeling

减轻流动人口肝细胞癌的负担：通过疾病模型改善预防和结果

• 批准号: 10558568
• 负责人: Kenneth Andrew Valles
• 金额: $ 5.27万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558568
• 关键词: Affect; Age; American; Cancer Etiology; Cessation of life; Characteristics; Chronic; Chronic viral hepatitis; Communities; Cost-Benefit Analysis; Country; Data; Data Set; Detection; Development; Disease; Disease Progression; Disease model; Ensure; Epidemic; Europe; European; European Union; Failure; Future; Generations; Goals; Guidelines; HIV; Health; Health Policy; Hepatitis; Hepatitis B Infection; Hepatitis C virus; Immigrant; Immigration; Incidence; Individual; Infection; Knowledge; Length; Liver Cirrhosis; Long-Term Care; Malaria; Malignant Neoplasms; Malignant neoplasm of liver; Measures; Mental disorders; Migrant; Modeling; Modification; Morbidity - disease rate; Outcome; Patient Care; Patients; Persons; Policies; Policy Maker; Population; Population Statistics; Prevalence; Prevention; Primary carcinoma of the liver cells; Process; Records; Research; Risk; Severities; Sweden; Testing; Treatment Cost; Tuberculosis; United States; Vaccination; Viral hepatitis; World Health Organization; age group; burden of illness; comorbidity; data registry; demographics; disease disparity; disorder risk; end stage liver disease; epidemiologic data; experience; health data; health management; human migration; improved; innovation; liver inflammation; low income country; migration; mortality; poor health outcome; preventable death; programs; risk stratification; routine screening; screening; screening policy

Project Summary Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer mortality in the United States. HCC is preventable, and it disproportionately affects migrants with unrecognized asymptomatic Chronic Viral Hepatitis (CVH). The long-term goal of this project is to reduce the occurrence of preventable liver cancer in migrant populations. The overall objective of this proposal is to estimate the Chronic Viral Hepatitis (CVH) and Hepatocellular Carcinoma (HCC) prevalence among migrants, to detect key identifiers associated with high- burden groups, and to describe the comorbidities and outcomes of those groups. The purpose of achieving this goal is to reduce the occurrence of preventable liver cancer in migrant populations. This study will contribute to this through the generation of the epidemiological data required for patients, practitioners, and policymakers alike to more readily identify the migrant groups that would benefit most from strategic screening and surveillance. The central hypothesis is that HCC and CVH risk and outcomes among migrants can be estimated by demographics. This will be tested by pursuing two specific aims: 1) Establish prevalence of CVH and HCC among migrant populations; and 2) Identify CVH and HCC comorbidities and outcomes within the migrant population. Under the first aim, a proven CVH and HCC disease model will be paired with migrant population statistics to establish the risk profiles for distinct migrant populations, including age group and country-of-origin. Under the second aim, an existing retrospective, population-wide health dataset will be utilized to identify common concomitant disease and outcomes among distinct migrant populations. The proposed research is innovative because it focuses on identifying key characteristics unique to specific migrant populations and establishing the associated CVH and HCC risk profiles. If achieved, the results are expected to be significant because they will contribute to resolving the current knowledge gaps in the disease burden and disparities of distinct migrant populations, allowing for risk stratifying and appropriate modifications to impact screening policy and practice.

项目概要 肝细胞癌（HCC）是美国癌症死亡率增长最快的原因。肝癌是 是可以预防的，而且它对患有未被识别的无症状慢性病毒性肝炎的移民造成了不成比例的影响 （CVH）。该项目的长期目标是减少流动人口中可预防肝癌的发生率 人口。该提案的总体目标是估计慢性病毒性肝炎 (CVH) 和 移民中的肝细胞癌 (HCC) 患病率，旨在检测与高风险相关的关键标识符 负担群体，并描述这些群体的合并症和结果。达到这个目的的目的 目标是减少流动人口中可预防肝癌的发生。这项研究将有助于 这是通过生成患者、从业者和政策制定者所需的流行病学数据来实现的 更容易地确定哪些移民群体将从战略筛选和 监视。 中心假设是移民中的 HCC 和 CVH 风险和结果可以通过以下方式估计 人口统计。这将通过追求两个具体目标进行测试：1) 确定 CVH 和 HCC 的患病率 在流动人口中； 2) 确定移民中的 CVH 和 HCC 合并症和结果 人口。第一个目标是，将经过验证的CVH和HCC疾病模型与流动人口配对 建立不同移民人口（包括年龄组和原籍国）风险概况的统计数据。 根据第二个目标，将利用现有的回顾性全人口健康数据集来确定 不同流动人口中常见的伴随疾病和结果。拟议的研究是 创新，因为它侧重于识别特定移民群体独有的关键特征， 建立相关的 CVH 和 HCC 风险概况。如果实现的话，预计成果将是显着的 因为它们将有助于解决当前在疾病负担方面的知识差距和不同群体之间的差异 不同的移民人口，允许风险分层和对影响筛查进行适当修改 政策和实践。