Connected Lives - Overcoming the Self through Empathy (CLOSE): A Dyadic, Multi-Method Study

互联生活 - 通过同理心克服自我（关闭）：二元、多方法研究

• 批准号: 10559597
• 负责人: Jessica Renee Andrews-Hanna
• 金额: $ 60.76万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10559597
• 关键词: 3-Dimensional; Address; Adult; Affect; Anxiety; Area; Behavior; Behavioral; Brain; Couples; Data; Diagnostic; Disparate; Emotional; Emotional disorder; Emotions; Empathy; Feedback; Feeling; Functional Magnetic Resonance Imaging; Future; Goals; Health; Heart; Hostility; Impaired health; Impairment; Individual; Intervention; Life; Link; Loneliness; Measures; Mediating; Mental Depression; Mental Health; Mental disorders; Methods; Mind; Modeling; Outcome; Participant; Partner in relationship; Patient Self-Report; Pattern; Personal Satisfaction; Psyche structure; Psychopathology; Questionnaires; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Sampling; Scientific Advances and Accomplishments; Services; Shapes; Social Behavior; Stress; Symptoms; Testing; Thinking; Time; Work; biopsychosocial factor; brain behavior; design; improved; interest; member; middle age; mobile application; negative affect; neural; neuroimaging; novel; primary outcome; prospective; smartphone application; social; social factors; social integration; social relationships; statistics; trait; young adult

PROJECT SUMMARY This project seeks to shed light on mechanisms underlying transdiagnostic risk for mental illness by integrating two traditionally disparate lines of research. One line of work indicates that repetitive negative thinking (RNT)—a transdiagnostic risk factor characterized by frequent, negative, self-focused thoughts— increases vulnerability for a range of mental health disorders, including depression and anxiety. A second line of work demonstrates that high-quality social relationships are associated with lower rates of mental and physical illness; conversely, relationship stress, hostility, and disconnection exacerbate loneliness, isolation, and mental and physical illness. This proposal will test a new model in which RNT and social connectedness work together as parts of an integrated whole. The central argument of this model is that RNT exerts its pernicious effects on mental health by impairing the ability to meaningfully connect with others through empathy—a critical component of social connection that involves sharing and understanding others’ emotions. Critical to this model is the hypothesis that RNT and empathy operate dyadically; that is, they affect both partners in a close relationship. To test this model, this project will implement a multilevel research design that integrates self-report, neuroimaging, and naturalistic observation to study RNT, social connection, and mental health in the context of established close relationships. Specifically, the project will employ a multi-method approach across 200 established romantic couples (young adults to those in middle age; N = 400) to assess the following aims: (1) Examine associations between RNT and partner-directed neural and behavioral empathy among romantic couples; (2) Determine the role of neural empathy in dyadic social-emotional and mental health outcomes; (3) Determine the role of RNT in dyadic mental health outcomes; and (4) Examine whether neural empathy mediates the dyadic association between RNT and longitudinal mental health outcomes. Advancing prior work, the proposed research will examine neural empathy in a novel and validated social feedback task using functional MRI in each member of the couple, to be modelled using dyadic statistics. Additionally, RNT and daily social behaviors will be assessed in everyday life using two mobile apps developed by the research team: Mind Window and the Electronically Activated Recorder (EAR). Finally, mental health will be assessed over 6 months to allow for prospective changes in the primary outcomes of interest. To tackle the study’s aims, this proposal brings together an interdisciplinary team of researchers with expertise spanning all facets of the proposed research: RNT, depression, neural empathy, social connectedness, dyadic modelling, and ambulatory assessment. Ultimately, this work holds promise for advancing scientific understanding of how individual and social risks for psychopathology operate together to shape emotional disorders. In turn, this research has the potential to help identify novel intervention targets to strengthen social connectedness in service of improving mental health.

项目摘要 该项目试图通过 整合了两个传统上不同的研究线。一项工作表明重复性负面 思维（RNT） - 一个经常，消极，自我关注思想的经诊断风险因素 增加了包括抑郁症和动画在内的一系列心理健康障碍的脆弱性。第二行 工作表明，高质量的社会关系与较低的心理和率有关 身体疾病；相反，关系应力，敌意和断开连接加剧了躺椅，隔离， 以及精神和身体疾病。该建议将测试一个新模型，其中RNT和社会联系 作为整体整体的一部分一起工作。该模型的核心论点是RNT导出了它的 通过损害通过有意义地与他人联系的能力，对心理健康的有害影响 同理心 - 社会联系的关键组成部分，涉及分享和理解他人的情绪。 对该模型至关重要的是，RNT和同理心在二元上运作。也就是说，它们都影响 伴侣处于亲密关系。为了测试该模型，该项目将实施多级研究设计 将自我报告，神经影像学和自然主义观察整合到研究RNT，社会联系和精神上 在建立的亲密关系的背景下健康。具体而言，该项目将采用多方法 跨200个既定的浪漫夫妇（年轻人到中年的年轻人； n = 400）来评估 以下目的：（1）检查RNT与伴侣指导的神经和行为之间的关联 浪漫夫妇之间的同理心； （2）确定神经同理心在二元社会情感和 心理健康结果； （3）确定RNT在二元心理健康结果中的作用； （4）检查 神经同理心是否介导了RNT和纵向心理健康之间的二元关联 结果。提前的工作，拟议的研究将在小说中检查神经同理心和经过验证 在这对夫妇的每个成员中使用功能性MRI的社会反馈任务，以二元模型建模 统计数据。此外，将使用两个移动应用程序在日常生活中评估RNT和日常社交行为 由研究团队开发：思维窗口和电子激活的录音机（EAR）。最后， 心理健康将在6个月内评估，以允许对 兴趣。为了解决研究的目标，该提案将一个研究人员组成的跨学科团队与 跨越拟议研究的所有方面的专业知识：RNT，抑郁，神经同理心，社会 连接性，二元建模和门诊评估。最终，这项工作对 促进对精神病理操作员个人和社会风险如何共同了解的科学理解 塑造情绪障碍。反过来，这项研究有可能帮助确定新颖的干预目标 加强社会联系，以改善心理健康。